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With the rapid global spread of COVID-19, more and more data related to this virus is becoming available, including genomic sequence data. The total number of genomic sequences that are publicly available on platforms such as GISAID is…

基因组学 · 定量生物学 2021-11-16 Sarwan Ali , Murray Patterson

Causal inference methods are widely applied in the fields of medicine, policy, and economics. Central to these applications is the estimation of treatment effects to make decisions. Current methods make binary yes-or-no decisions based on…

机器学习 · 计算机科学 2020-04-24 Will Y. Zou , Smitha Shyam , Michael Mui , Mingshi Wang , Jan Pedersen , Zoubin Ghahramani

Estimating counterfactual outcomes over time has the potential to unlock personalized healthcare by assisting decision-makers to answer ''what-iF'' questions. Existing causal inference approaches typically consider regular, discrete-time…

机器学习 · 计算机科学 2022-06-17 Nabeel Seedat , Fergus Imrie , Alexis Bellot , Zhaozhi Qian , Mihaela van der Schaar

Pooled analyses that aggregate data from multiple studies are becoming increasingly common in collaborative epidemiologic research in order to increase the size and diversity of the study population. However, biomarker measurements from…

统计方法学 · 统计学 2025-05-06 Yujie Wu , Xiao Wu , Mitchell H. Gail , Regina G. Ziegler , Stephanie A. Smith-Warner , Molin Wang

Survival prediction is a crucial task associated with cancer diagnosis and treatment planning. This paper presents a novel approach to survival prediction by harnessing comprehensive information from CT and PET scans, along with associated…

图像与视频处理 · 电气工程与系统科学 2024-10-01 Aiman Farooq , Deepak Mishra , Santanu Chaudhury

This essay is based on the joint project with 111, Inc. The pharmacy e-Commerce business grows rapidly in recent years with the ever-increasing medical demand during the pandemic. A big challenge for online pharmacy platforms is drug…

人工智能 · 计算机科学 2022-07-05 Dong Chenxi , QP Zhang , B Hu , JC Zhang , Dl Lin

Learning efficient representations for concepts has been proven to be an important basis for many applications such as machine translation or document classification. Proper representations of medical concepts such as diagnosis, medication,…

机器学习 · 计算机科学 2016-02-18 Edward Choi , Mohammad Taha Bahadori , Elizabeth Searles , Catherine Coffey , Jimeng Sun

Duplication, whether exact or partial, is a common issue in many datasets. In clinical notes data, duplication (and near duplication) can arise for many reasons, such as the pervasive use of templates, copy-pasting, or notes being generated…

数据库 · 计算机科学 2017-04-20 Sanjeev Shenoy , Tsung-Ting Kuo , Rodney Gabriel , Julian McAuley , Chun-Nan Hsu

This paper investigates the design of low-complexity error correction codes for the verification step in continuous variable quantum key distribution (CVQKD) systems. We design new coding schemes based on quasi-cyclic repeat-accumulate…

信息论 · 计算机科学 2015-10-14 Sarah J. Johnson , Vikram A. Chandrasetty , Andrew M. Lance

Autocorrelations in MCMC chains increase the variance of the estimators they produce. We propose the occlusion process to mitigate this problem. It is a process that sits upon an existing MCMC sampler, and occasionally replaces its samples…

统计计算 · 统计学 2024-11-20 Max Hird , Florian Maire

The discipline of process mining has a solid track record of successful applications to the healthcare domain. Within such research space, we conducted a case study related to the Intensive Care Unit (ICU) ward of the Uniklinik Aachen…

To estimate casual treatment effects, we propose a new matching approach based on the reduced covariates obtained from sufficient dimension reduction. Compared to the original covariates and the propensity score, which are commonly used for…

统计方法学 · 统计学 2017-02-03 Wei Luo , Yeying Zhu

Many practical applications of AI in medicine consist of semi-supervised discovery: The investigator aims to identify features of interest at a resolution more fine-grained than that of the available human labels. This is often the scenario…

计算与语言 · 计算机科学 2020-04-08 Allen Schmaltz , Andrew Beam

Automated breast cancer detection via computer vision techniques is challenging due to the complex nature of breast tissue, the subtle appearance of cancerous lesions, and variations in breast density. Mainstream techniques primarily focus…

定量方法 · 定量生物学 2025-12-11 Noor Ul Huda Shah , Tanveer Hussain , Amr Ahmed , Yonghuai Liu , Usman Ali , Ardhendu Behera

Statistical matching is an effective method for estimating causal effects in which treated units are paired with control units with ``similar'' values of confounding covariates prior to performing estimation. In this way, matching helps…

统计方法学 · 统计学 2023-09-13 Sanjeewani Weerasingha , Michael J. Higgins

Background: Patient recruitment in clinical trials is hindered by complex eligibility criteria and labor-intensive chart reviews. Prior research using text-only models have struggled to address this problem in a reliable and scalable way…

计算与语言 · 计算机科学 2025-03-20 Anatole Callies , Quentin Bodinier , Philippe Ravaud , Kourosh Davarpanah

Traditional disease surveillance can be augmented with a wide variety of real-time sources such as, news and social media. However, these sources are in general unstructured and, construction of surveillance tools such as taxonomical…

机器学习 · 计算机科学 2016-06-07 Saurav Ghosh , Prithwish Chakraborty , Emily Cohn , John S. Brownstein , Naren Ramakrishnan

The International Classification of Diseases (ICD) system is the international standard for classifying diseases and procedures during a healthcare encounter and is widely used for healthcare reporting and management purposes. Assigning…

计算与语言 · 计算机科学 2022-04-25 George Michalopoulos , Michal Malyska , Nicola Sahar , Alexander Wong , Helen Chen

Bound-to-Bound Data Collaboration (B2BDC) provides a natural framework for addressing both forward and inverse uncertainty quantification problems. In this approach, QOI (quantity of interest) models are constrained by related experimental…

最优化与控制 · 数学 2019-04-02 Arun Hegde , Wenyu Li , James Oreluk , Andrew Packard , Michael Frenklach

The concept of personalised medicine in cancer therapy is becoming increasingly important. There already exist drugs administered specifically for patients with tumours presenting well-defined mutations. However, the field is still in its…

生物大分子 · 定量生物学 2024-08-26 Abbi Abdel-Rehim , Oghenejokpeme Orhobor , Gareth Griffiths , Larisa Soldatova , Ross D. King