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Bacteria live in environments that are continuously fluctuating and changing. Exploiting any predictability of such fluctuations can lead to an increased fitness. On longer timescales bacteria can "learn" the structure of these fluctuations…

细胞行为 · 定量生物学 2021-01-05 Stefan Landmann , Caroline M. Holmes , Mikhail Tikhonov

Molecular communication is an expanding body of research. Recent advances in biology have encouraged using genetically engineered bacteria as the main component in the molecular communication. This has stimulated a new line of research that…

信息论 · 计算机科学 2012-09-13 Arash Einolghozati , Mohsen Sardari , Faramarz Fekr

Many cellular components are present in such low numbers that individual stochastic production and degradation events lead to significant fluctuations in molecular abundances. Although feedback control can, in principle, suppress such…

分子网络 · 定量生物学 2025-12-25 Ryan Ripsman , Brayden Kell , Andreas Hilfinger

Proteins are polymerized by cyclic machines called ribosome which use their messenger RNA (mRNA) track also as the corresponding template and the process is called translation. We explore, in depth and detail, the stochastic nature of the…

生物物理 · 物理学 2009-11-13 Ashok Garai , Debashish Chowdhury , T. V. Ramakrishnan

We present a stochastic framework to study signal transmission in a generic two-step cascade $\text{S} \rightarrow \text{X} \rightarrow \text{Y}$. Starting from a set of Langevin equations obeying Gaussian noise processes we calculate the…

分子网络 · 定量生物学 2016-06-08 Ayan Biswas , Suman K Banik

Simplified stochastic models are widely used in the study of frequency-resolved noise propagation in biochemical reaction networks, a common measure being the coherence between random fluctuations in molecule number trajectories. Such…

分子网络 · 定量生物学 2025-11-03 Juan David Marmolejo Lozano , Nikola Popovic , Ramon Grima

Living cells are continually exposed to environmental signals that vary in time. These signals are detected and processed by biochemical networks, which are often highly stochastic. To understand how cells cope with a fluctuating…

分子网络 · 定量生物学 2012-06-01 Wiet de Ronde , Filipe Tostevin , Pieter Rein ten Wolde

Understanding the relationship between spontaneous stochastic fluctuations and the topology of the underlying gene regulatory network is of fundamental importance for the study of single-cell stochastic gene expression. Here by solving the…

分子网络 · 定量生物学 2017-10-25 Chen Jia , Peng Xie , Min Chen , Michael Q. Zhang

The effect of stochasticity, in the form of Gaussian white noise, in a predator-prey model with two distinct time-scales is presented. A supercritical singular Hopf bifurcation yields a Type II excitability in the deterministic model. We…

动力系统 · 数学 2017-07-20 Susmita Sadhu

We investigate the propagation of information through one-dimensional quantum chains in fluctuating external fields. We find that information propagation is suppressed, but in a quite different way compared to the situation with static…

量子物理 · 物理学 2010-03-11 Christian K. Burrell , Jens Eisert , Tobias J. Osborne

Robust oscillations play crucial roles in a wide variety of biological processes and are often generated by deterministic mechanisms. However, stochastic fluctuations often generate complex perturbations of these deterministic oscillations,…

动力系统 · 数学 2026-03-27 Xuesong Bai , Jonathan Touboul , Thomas G. Fai

Using the formalism of information theory, we analyze the mechanism of information transduction in a simple one-step signaling cascade S$\rightarrow$X representing the gene regulatory network. Approximating the signaling channel to be…

分子网络 · 定量生物学 2018-11-14 Mintu Nandi , Ayan Biswas , Suman K Banik , Pinaki Chaudhury

Stochasticity is both exploited and controlled by cells. Although the intrinsic stochasticity inherent in biochemistry is relatively well understood, cellular variation, or 'noise', is predominantly generated by interactions of the system…

分子网络 · 定量生物学 2008-09-18 Vahid Shahrezaei , Julien F Ollivier , Peter S Swain

The transport of molecules through biological and synthetic nanopores is governed by multiple stochastic processes that lead to noisy, fluctuating currents. Disentangling the characteristics of different noise-generating mechanisms is…

软凝聚态物质 · 物理学 2024-10-03 Stuart F. Knowles , Eleanor K. R. Mackay , Alice L. Thorneywork

Modeling stochasticity in gene regulatory networks is an important and complex problem in molecular systems biology. To elucidate intrinsic noise, several modeling strategies such as the Gillespie algorithm have been used successfully. This…

分子网络 · 定量生物学 2013-01-18 David Murrugarra , Alan Veliz-Cuba , Boris Aguilar , Seda Arat , Reinhard Laubenbacher

Based on a non-equilibrium mechanism for spatial pattern formation we study how position information can be controlled by locally coupled discrete dynamical networks, similar to gene regulation networks of cells in a developing…

分子网络 · 定量生物学 2009-08-26 Thimo Rohlf , Stefan Bornholdt

Changes in a cell's external or internal conditions are usually reflected in the concentrations of the relevant transcription factors. These proteins in turn modulate the expression levels of the genes under their control and sometimes need…

分子网络 · 定量生物学 2013-08-01 Gasper Tkacik , Curtis G Callan , William Bialek

Biological neurons receive multiple noisy oscillatory signals, and their dynamical response to the superposition of these signals is of fundamental importance for information processing in the brain. Here we study the response of neural…

神经元与认知 · 定量生物学 2017-08-28 Daqing Guo , Matjaz Perc , Yangsong Zhang , Peng Xu , Dezhong Yao

Networks of interacting, communicating subsystems are common in many fields, from ecology, biology, epidemiology to engineering and robotics. In the presence of noise and uncertainty, inter- actions between the individual components can…

统计力学 · 物理学 2017-11-01 Ira B. Schwartz , Klimka Szwaykowska , Thomas W. Carr

Dual phospho/dephosphorylation cycles, as well as covalent enzymatic-catalyzed modifications of substrates, are widely diffused within cellular systems and are crucial for the control of complex responses such as learning, memory and…

生物物理 · 物理学 2015-05-28 A. Bazzani , G. Castellani , E. Giampieri , D. Remondini , L. N Cooper