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The actin cortex is a thin layer of actin, myosin, and actin binding proteins that underlies the membrane of most animal cells. It is highly dynamic and can undergo remodelling on time-scales of tens of seconds thanks to protein turnover…

细胞行为 · 定量生物学 2020-06-24 Manasi Kelkar , Pierre Bohec , Guillaume Charras

Variations of transport efficiency in structured environments between distinct individuals in actively self-propelled systems is both hard to study and poorly understood. Here, we study the transport of a non-tumbling {\ecoli} strain, an…

软凝聚态物质 · 物理学 2023-08-28 Pooja Chopra , David Quint , Ajay Gopinathan , Bin Liu

One of simplest examples of navigation found in nature is run-and-tumble chemotaxis. Tumbles reorient cells randomly, and cells can drift toward attractants or away from repellents by biasing the frequency of these events. The post-tumble…

软凝聚态物质 · 物理学 2017-09-14 Julius B. Kirkegaard , Raymond E. Goldstein

A simple model is proposed that describes the various morphodynamic principles of migrating cells from polar to amoeboidal motions. The model equation is derived using competing internal cellular compass variables and symmetries of the…

细胞行为 · 定量生物学 2013-01-30 Shuji Ishihara

Cell polarization is a critical process that separates molecular species into two distinct regions in prokaryotic and eukaryotic cells, guiding biological processes such as cell division and cell differentiation. Although several underlying…

分子网络 · 定量生物学 2025-01-28 Yixuan Chen , Guoye Guan , Lei-Han Tang , Chao Tang

Bacteria such as Escherichia coli move about in a series of runs and tumbles: while a run state (straight motion) entails all the flagellar motors spinning in counterclockwise mode, a tumble is caused by a shift in the state of one or more…

定量方法 · 定量生物学 2020-01-08 C. S. Renadheer , Ushasi Roy , Manoj Gopalakrishnan

We investigate how light polarization affects the motion of photo-responsive algae, \textit{Euglena gracilis}. In a uniformly polarized field, cells swim approximately perpendicular to the polarization direction and form a nematic state…

软凝聚态物质 · 物理学 2021-02-09 Siyuan Yang , Mingji Huang , Yongfeng Zhao , H. P. Zhang

There is now growing evidence of the emergence and biological functionality of liquid crystal features, including nematic order and topological defects, in cellular tissues. However, how such features that intrinsically rely on particle…

软凝聚态物质 · 物理学 2019-02-06 Romain Mueller , Julia Yeomans , Amin Doostmohammadi

We propose a model for cell migration where epithelial cells are able to detect trajectories of other cells and try to follow them. As cells move along in 2D cell culture, they mark their paths by loosing tiny parts of cytoplasm. Any cell…

凝聚态物理 · 物理学 2009-11-07 Stefan Thurner , Nikolaus Wick , Rudolf Hanel , Roland Sedivy , Lukas Huber

Reaction-diffusion processes across layered media arise in several scientific domains such as pattern-forming E. coli on agar substrates, epidermal-mesenchymal coupling in development, and symmetry-breaking in cell polarisation. We develop…

Cooperative behaviors arising from bacterial cell-to-cell communication can be modeled by reaction-diffusion equations having only a single diffusible component. This paper presents the following three contributions for the systematic…

系统与控制 · 计算机科学 2016-11-15 Hiroki Miyazako , Yutaka Hori , Shinji Hara

We develop a model of amoeboid cell motility based on active gel theory. Modeling the motile apparatus of a eukaryotic cell as a confined layer of finite length of poroelastic active gel permeated by a solvent, we first show that, due to…

生物物理 · 物理学 2015-06-12 A. C. Callan-Jones , R. Voituriez

Signaling molecules play an important role for many cellular functions. We investigate here a general system of two membrane reaction-diffusion equations coupled to a diffusion equation inside the cell by a Robin-type boundary condition and…

偏微分方程分析 · 数学 2015-06-16 Andreas Rätz , Matthias Röger

Cell crawling is critical to biological development, homeostasis and disease. In many cases, cell trajectories are quasi-random-walk. In vitro assays on flat surfaces often described such quasi-random-walk cell trajectories as…

We analyse a generic motility model, with the motility mechanism arising by contractile stress due to the interaction of myosin and actin. A hydrodynamic active polar gel theory is used to model the cytoplasm of a cell and is combined with…

细胞行为 · 定量生物学 2015-07-06 Wieland Marth , Simon Praetorius , Axel Voigt

Understanding how bacteria move in porous media is critical to applications in healthcare, agriculture, environmental remediation, and chemical sensing. Recent work has demonstrated that E. coli, which moves by run-and-tumble dynamics in a…

软凝聚态物质 · 物理学 2022-06-07 Tapomoy Bhattacharjee , Sujit S. Datta

Cellular locomotion often involves the motion of thin, elastic filaments, such as cilia and flagella, in viscous environments. The manuscript serves as a general introduction to the topic of modelling microscale elastohydrodynamics. We…

软凝聚态物质 · 物理学 2024-10-15 Maciej Lisicki

Structure formation and constant reorganization of the actin cytoskeleton are key requirements for the function of living cells. Here we show that a minimal reconstituted system consisting of actin filaments, crosslinking molecules and…

生物物理 · 物理学 2015-05-27 Simone Köhler , Volker Schaller , Andreas R. Bausch

Bacterial cellulose is an important class of biomaterials which can be grown in well-controlled laboratory and industrial conditions. The cellulose structure is affected by several biological, chemical and environmental factors, including…

生物物理 · 物理学 2021-07-28 Sung-Ha Hong , Jia Yang , Mahdi Davoodianidalik , Horst Punzmann , Michael Shats , Hua Xia

Migration of animal cells is based on the interplay between actin polymerization at the front, adhesion along the cell-substrate interface, and actomyosin contractility at the back. Active gel theory has been used before to demonstrate that…

细胞行为 · 定量生物学 2024-12-11 Valentin Wössner , Oliver M. Drozdowski , Falko Ziebert , Ulrich S. Schwarz