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Skin cancer is a serious and potentially fatal disease caused by DNA damage. Early detection significantly increases survival rates, making accurate diagnosis crucial. In this groundbreaking study, we present a hybrid framework based on…
Multiplex Imaging (MI) enables the simultaneous visualization of multiple biological markers in separate imaging channels at subcellular resolution, providing valuable insights into cell-type heterogeneity and spatial organization. However,…
Today, skin cancer is considered as one of the most dangerous and common cancers in the world which demands special attention. Skin cancer may be developed in different types; including melanoma, actinic keratosis, basal cell carcinoma,…
Histopathological image classification is an important task in medical image analysis. Recent approaches generally rely on weakly supervised learning due to the ease of acquiring case-level labels from pathology reports. However,…
Although much progress has been made in classification with high-dimensional features \citep{Fan_Fan:2008, JGuo:2010, CaiSun:2014, PRXu:2014}, classification with ultrahigh-dimensional features, wherein the features much outnumber the…
Despite fluorescent cell-labelling being widely employed in biomedical studies, some of its drawbacks are inevitable, with unsuitable fluorescent probes or probes inducing a functional change being the main limitations. Consequently, the…
Mitochondrial diseases are currently untreatable due to our limited understanding of their pathology. We study the expression of various mitochondrial proteins in skeletal myofibres (SM) in order to discover processes involved in…
Algorithmic decision support is rapidly becoming a staple of personalized medicine, especially for high-stakes recommendations in which access to certain information can drastically alter the course of treatment, and thus, patient outcome;…
Melanoma diagnosed and treated in its early stages can increase the survival rate. A projected increase in skin cancer incidents and a dearth of dermatopathologists have emphasized the need for computational pathology (CPATH) systems. CPATH…
Deep learning techniques have proven high accuracy for identifying melanoma in digitised dermoscopic images. A strength is that these methods are not constrained by features that are pre-defined by human semantics. A down-side is that it is…
Representation learning offers a conduit to elucidate distinctive features within the latent space and interpret the deep models. However, the randomness of lesion distribution and the complexity of low-quality factors in medical images…
Histopathological image analysis is the gold standard to diagnose cancer. Carcinoma is a subtype of cancer that constitutes more than 80% of all cancer cases. Squamous cell carcinoma and adenocarcinoma are two major subtypes of carcinoma,…
Due to cellular heterogeneity, cell nuclei classification, segmentation, and detection from pathological images are challenging tasks. In the last few years, Deep Convolutional Neural Networks (DCNN) approaches have been shown…
Accurate diagnostics of a skin lesion is a critical task in classification dermoscopic images. In this research, we form a new type of image features, called hybrid features, which has stronger discrimination ability than single method…
Interpretability of deep learning is widely used to evaluate the reliability of medical imaging models and reduce the risks of inaccurate patient recommendations. For models exceeding human performance, e.g. predicting RNA structure from…
Circulating tumor cells (CTCs) are cancer cells found in the bloodstream that serve as biomarkers for early cancer detection, prognostication, and disease monitoring. However, CTC detection remains challenging due to low cell abundance and…
Molecular subtyping of PDAC into basal-like and classical has established prognostic and predictive value. However, its use in clinical practice is limited by cost, turnaround time, and tissue requirements, thereby restricting its…
Pathologists find tedious to examine the status of the sentinel lymph node on a large number of pathological scans. The examination process of such lymph node which encompasses metastasized cancer cells is histopathologically organized.…
With a large influx of dermoscopy images and a growing shortage of dermatologists, automatic dermoscopic image analysis plays an essential role in skin cancer diagnosis. In this paper, a new deep fully convolutional neural network (FCNN) is…
Our goal is to bridge human and machine intelligence in melanoma detection. We develop a classification system exploiting a combination of visual pre-processing, deep learning, and ensembling for providing explanations to experts and to…