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We propose a novel approach to generate samples from the conditional distribution of patient-specific cardiovascular models given a clinically aquired image volume. A convolutional neural network architecture with dropout layers is first…

定量方法 · 定量生物学 2021-09-01 Gabriel Maher , Casey Fleeter , Daniele Schiavazzi , Alison Marsden

Uncertainty estimation, which provides a means of building explainable neural networks for medical imaging applications, have mostly been studied for single deep learning models that focus on a specific task. In this paper, we propose a…

计算机视觉与模式识别 · 计算机科学 2023-10-02 Leonhard F. Feiner , Martin J. Menten , Kerstin Hammernik , Paul Hager , Wenqi Huang , Daniel Rueckert , Rickmer F. Braren , Georgios Kaissis

I apply the method of characteristics to both bi-directional and uni-directional pulse propagation in dispersionless media containing nonlinearity of arbitrary order. The differing analytic predictions for the shocking distance quantify the…

光学 · 物理学 2008-07-24 P. Kinsler

In cardiac electrophysiology, it is important to predict the necessary conditions for conduction failure, the failure of the cardiac excitation propagation even in the presence of normal excitable tissue, in high-dimensional anisotropic…

医学物理 · 物理学 2013-01-22 Sehun Chun

Simulations of coronary hemodynamics have improved non-invasive clinical risk stratification and treatment outcomes for coronary artery disease, compared to relying on anatomical imaging alone. However, simulations typically use empirical…

Arterial pulse waves contain clinically useful information: their intensity varies with cardiac performance, their speed (pulse wave velocity; PWV) depends on arterial stiffness and their reflection is affected by conduit artery tone. Here…

医学物理 · 物理学 2022-05-31 Ethan M Rowland , Kai Riemer , Kevin Lichtenstein , Mengxing Tang , Peter Weinberg

Fluid filled pipes are ubiquitous in both man-made constructions and living organisms. In the latter, biological pipes, such as arteries, have unique properties as their walls are made of soft, incompressible, highly deformable materials.…

软凝聚态物质 · 物理学 2026-03-16 Pierre Chantelot , Alexandre Delory , Claire Prada , Fabrice Lemoult

In the context of numerical simulations of the vascular system, local geometric uncertainties have not yet been examined in sufficient detail due to model complexity and the associated large numerical effort. Such uncertainties are related…

Most approximations for stochastic differential equations with high-dimensional, non-Gaussian inputs suffer from a rapid (e.g., exponential) increase of computational cost, an issue known as the curse of dimensionality. In astrodynamics,…

应用统计 · 统计学 2017-08-30 Marc Balducci , Brandon Jones , Alireza Doostan

Central to the clinical adoption of patient-specific modeling strategies is demonstrating that simulation results are reliable and safe. Simulation frameworks must be robust to uncertainty in model input(s), and levels of confidence should…

Predictive uncertainty estimation remains a challenging problem precluding the use of deep neural networks as subsystems within safety-critical applications. Aleatoric uncertainty is a component of predictive uncertainty that cannot be…

机器学习 · 计算机科学 2023-12-12 Angel Daruna , Yunye Gong , Abhinav Rajvanshi , Han-Pang Chiu , Yi Yao

We present a generalizable uncertainty quantification (UQ) and visualization framework for lattice Boltzmann method simulations of high Reynolds number vascular flows, demonstrated on a patient-specific stenosed aorta. The framework…

Waves propagating through weakly disordered smooth linear media undergo a universal phenomenon called branched flow. Branched flow has been observed and studied experimentally in various systems by considering coherent waves. Recent…

偏微分方程分析 · 数学 2025-04-09 Josselin Garnier , Antonio Picozzi , Theo Torres

In Computational Fluid Dynamics (CFD) studies composed of the coupling of different simulations, the uncertainty in one stage may be propagated to the following stage and affect the accuracy of the prediction. In this paper, a framework for…

流体动力学 · 物理学 2019-10-29 F. -J. Granados-Ortiz , J. Ortega-Casanova , C. -H. Lai

In the context of forecasting temperature and pressure fields in high-intensity focussed ultrasound, the accuracy of predictive models is critical for the safety and efficacy of treatment. In such fields inertial cavitation is often…

医学物理 · 物理学 2010-07-06 David Sinden , Eleanor Stride , Nader Saffari

Uncertainty propagation in non-linear dynamical systems has become a key problem in various fields including control theory and machine learning. In this work we focus on discrete-time non-linear stochastic dynamical systems. We present a…

系统与控制 · 电气工程与系统科学 2024-09-12 Eduardo Figueiredo , Andrea Patane , Morteza Lahijanian , Luca Laurenti

We investigate flow of incompressible fluid in a cylindrical tube with elastic walls. The radius of the tube may change along its length. The discussed problem is connected to the blood flow in large human arteries and especially to…

流体动力学 · 物理学 2015-09-30 Zlatinka I. Dimitrova

In this article we study the problem of quantifying the uncertainty in an experiment with a technical system. We propose new density estimates which combine observed data of the technical system and simulated data from an (imperfect)…

统计理论 · 数学 2020-12-21 Sebastian Kersting , Michael Kohler

We present experimental evidence of multiple blood flow configurations in a relatively simple microfluidic network under constant inlet conditions. We provide evidence of multistability and unsteady dynamics and find good agreement with a…

流体动力学 · 物理学 2024-10-08 Mathieu Alonzo , Nathaniel J. Karst , Thomas Podgorski , John B. Geddes , Gwennou Coupier

In this paper, we consider discrete-time non-linear stochastic dynamical systems with additive process noise in which both the initial state and noise distributions are uncertain. Our goal is to quantify how the uncertainty in these…

系统与控制 · 电气工程与系统科学 2025-05-19 Steven Adams , Eduardo Figueiredo , Luca Laurenti