相关论文: Mucociliary Transport in Healthy and Diseased Envi…
Mucociliary clearance in mammals serves as the primary defense mechanism for removing particulate matter deposited in the pulmonary airways. Dysfunctions in this process are linked to serious respiratory diseases and can hinder effective…
The mucus on the bronchial wall forms a thin layer of non-Newtonian fluid. One of the roles of mucus is to protect the lungs by capturing inhaled pollutants. It is transported by mucocilliary clearance toward the tracheo-pharyngeal…
We study the transport and deposition of inhaled aerosols in a mid-generation, mucus-lined lung airway, with the aim of understanding if and how airborne particles can avoid the mucus and deposit on the airway wall -- an outcome that is…
Micro-scale cilia play a vital role in mucociliary clearance (MCC) in the human respiratory airways. In this numerical study, we examine fluid transport driven by the active beating of a single filament immersed in a three-dimensional…
Ciliated organs transport viscous fluids through confined ducts, yet how duct morphology and ciliary activity jointly set the limits of flow rate and sustainable pressure remains unclear. Here, we model dense arrays of beating cilia lining…
Airway mucus is a complex gel with an anisotropic three-dimensional network structure. As a crucial component of the respiratory defense barrier, it plays a vital role in maintaining airway hydration and supporting the function of airway…
Lung airways are lined by a film of mucus which protects the epithelium from inhaled particles. To maintain a uniform coating, the mucus that is secreted into airways must be distributed into a film by wall-attached cilia, which constantly…
Mucus is a viscoelastic gel secreted by the pulmonary epithelium in the tracheobronchial region of the lungs. The coordinated beating of cilia moves mucus upwards towards pharynx, removing inhaled pathogens and particles from the airways.…
Mucus is a biological gel covering the surface of several tissues and insuring key biological functions, including as a protective barrier against dehydration, pathogens penetration, or gastric acids. Mucus biological functioning requires a…
Large groups of active cilia collectively beat in a fluid medium as metachronal waves, essential for some microorganisms motility and for flow generation in mucociliary clearance. Several models can predict the emergence of metachronal…
Motile cilia are used by many eukaryotic cells to transport flow. Cilia-driven flows are important to many physiological functions, yet a deep understanding of the interplay between the mechanical structure of cilia and their physiological…
The yield stress and shear thinning properties of mucus are identified as critical for ciliary coordination and mucus transport in human airways. We use here numerical simulations to explore the hydrodynamic coupling of cilia and mucus with…
The airflow in the bronchi applies a shear stress on the bronchial mucus, which can move the mucus. The air--mucus interaction plays an important role in cough and in chest physiotherapy (CP). The conditions under which it induces a…
Airway clearance by coughing is a key mechanism for mucus transport, particularly in obstructive lung diseases associated with altered mucus rheology. We investigate the dynamics of a viscoplastic liquid film driven by flow in a turbulent…
We use a 3D computational model to study the fluid transport and mixing due to the beating of an infinite array of cilia. In accord with recent experiments, we observe two distinct regions: a fluid transport region above the cilia and a…
Metabolic substrates, such as oxygen and glucose, are rapidly delivered to the cell through filtration across microvessels walls. Modelling this important process is complicated by the coupling between flow and transport equations, which…
Esophageal transport is a physiological process that mechanically transports an ingested food bolus from the pharynx to the stomach via the esophagus, a multi-layered muscular tube. This process involves interactions between the bolus, the…
We present pore-scale simulations of two-phase flows in a reconstructed fibrous porous layer. The three dimensional microstructure of the material, a fuel cell gas diffusion layer, is acquired via X-ray computed tomography and used as input…
In this note, we revisit the problem of the pressure-driven transport of a meniscus through a narrow cylindrical capillary or pore. This generic process finds many applications in science and technology. As it is known that Direct Numerical…
In cystic fibrosis (CF), impaired mucociliary clearance leads to chronic infection and inflammation. However, cilia beating features in a CF altered environment, consisting of dehydrated airway surface liquid layer and abnormal mucus, has…