相关论文: Characterization of Large-Scale Functional Brain N…
One of the main goals of neuroscience is to understand how an organism's cognitive capacities or physiological states are potentially related to brain activities that involve the interaction of multiple brain structures and cortical areas.…
Anesthetic agents are neurotropic drugs capable of inducing significant alterations in the thalamocortical system, promoting a profound decrease in awareness and level of consciousness. There is experimental evidence that general anesthesia…
Anesthetic agents are known to induce a range of alterations in cortical electrophysiological activity, such as the rise of signature patterns, changes in statistical properties, and altered dynamic behavior of neural records. Plenty of…
Propofol, when administered for general anesthesia, induces oscillatory dynamic brain states that are thought to underlie the drug's pharmacological effects. Despite the elucidation of propofol's mechanisms of action at the molecular level,…
Loss of cortical integration and changes in the dynamics of electrophysiological brain signals characterize the transition from wakefulness towards unconsciousness. The common mechanism underlying these observations remains unknown. In this…
Global brain activity self-organizes into discrete patterns characterized by distinct behavioral observables and modes of information processing. The human thalamocortical system is a densely connected network where local neural activation…
The continuous integration of experimental data into coherent models of the brain is an increasing challenge of modern neuroscience. Such models provide a bridge between structure and activity, and identify the mechanisms giving rise to…
Higher brain function relies upon the ability to flexibly integrate information across specialized communities of brain regions, however it is unclear how this mechanism manifests over time. In this study, we use time-resolved network…
At the macroscale, the brain operates as a network of interconnected neuronal populations, which display rhythmic dynamics that support interareal communication. Understanding how stimulation of a particular brain area impacts such…
Understanding the relationship between large-scale structural and functional brain networks remains a crucial issue in modern neuroscience. Recently, there has been growing interest in investigating the role of homeostatic plasticity…
Structure entails function and thus a structural description of the brain will help to understand its function and may provide insights into many properties of brain systems, from their robustness and recovery from damage, to their dynamics…
Recently, there has been increased interest in fusing multimodal imaging to better understand brain organization. Specifically, accounting for knowledge of anatomical pathways connecting brain regions should lead to desirable outcomes such…
Experimental fMRI studies have shown that spontaneous brain activity i.e. in the absence of any external input, exhibit complex spatial and temporal patterns of co-activity between segregated brain regions. These so-called large-scale…
Open problems abound in the theory of complex networks, which has found successful application to diverse fields of science. With the aim of further advancing the understanding of the brain's functional connectivity, we propose to evaluate…
The dynamical mechanism underlying the processes of anesthesia-induced loss of consciousness and recovery is key to gaining insights into the working of the nervous system. Previous experiments revealed an asymmetry between neural signals…
Dynamic functional connectivity is an effective measure for the brain's responses to continuous stimuli. We propose an inferential method to detect the dynamic changes of brain networks based on time-varying graphical models. Whereas most…
The relation between large-scale brain structure and function is an outstanding open problem in neuroscience. We approach this problem by studying the dynamical regime under which realistic spatio-temporal patterns of brain activity emerge…
The study of dynamical systems defined on complex networks provides a natural framework with which to investigate myriad features of neural dynamics, and has been widely undertaken. Typically, however, networks employed in theoretical…
This review provides a dynamical systems perspective on psychiatric symptoms and disease, and discusses its potential implications for diagnosis, prognosis, and treatment. After a brief introduction into the theory of dynamical systems, we…
Brain functional connectome, the collection of interconnected neural circuits along functional networks, is one of the most cutting edge neuroimaging traits, and has a potential to play a mediating role within the effect pathway between an…