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Parkinson's disease (PD), a severe and progressive neurological illness, affects millions of individuals worldwide. For effective treatment and management of PD, an accurate and early diagnosis is crucial. This study presents a deep…

信号处理 · 电气工程与系统科学 2023-08-16 Niloufar Delfan , Mohammadreza Shahsavari , Sadiq Hussain , Robertas Damaševičius , U. Rajendra Acharya

Many complex networks, ranging from social to biological systems, exhibit structural patterns consistent with an underlying hyperbolic geometry. Revealing the dimensionality of this latent space can disentangle the structural complexity of…

Multimodal brain networks characterize complex connectivities among different brain regions from both structural and functional aspects and provide a new means for mental disease analysis. Recently, Graph Neural Networks (GNNs) have become…

神经元与认知 · 定量生物学 2022-05-25 Yanqiao Zhu , Hejie Cui , Lifang He , Lichao Sun , Carl Yang

This paper describes how realistic neuromorphic networks can have their connectivity fully characterized in analytical fashion. By assuming that all neurons have the same shape and are regularly distributed along the two-dimensional…

无序系统与神经网络 · 物理学 2007-05-23 Luciano da Fontoura Costa , Marconi Soares Barbosa

Identification of disease genes, which are a set of genes associated with a disease, plays an important role in understanding and curing diseases. In this paper, we present a biomedical knowledge graph designed specifically for this…

Most complex systems can be captured by graphs or networks. Networks connect nodes (e.g.\ neurons) through edges (synapses), thus summarizing the system's structure. A popular way of interrogating graphs is community detection, which…

物理与社会 · 物理学 2024-09-23 Luis F Seoane

Developing reliable methods to discriminate different transient brain states that change over time is a key neuroscientific challenge in brain imaging studies. Topological data analysis (TDA), a novel framework based on algebraic topology,…

神经元与认知 · 定量生物学 2023-12-19 Moo K. Chung , Soumya Das , Hernando Ombao

In this work we apply a novel, accurate, fast, and robust physics-informed neural network framework for data-driven parameters discovery of problems modeled via parametric ordinary differential equations (ODEs) called the Extreme Theory of…

计算物理 · 物理学 2020-08-14 Enrico Schiassi , Andrea D'Ambrosio , Mario De Florio , Roberto Furfaro , Fabio Curti

An increasingly important brain function analysis modality is functional connectivity analysis which regards connections as statistical codependency between the signals of different brain regions. Graph-based analysis of brain connectivity…

信号处理 · 电气工程与系统科学 2024-01-08 Fengfan Zhao , Ercan Engin Kuruoglu

Correlations in the signal observed via functional Magnetic Resonance Imaging (fMRI), are expected to reveal the interactions in the underlying neural populations through hemodynamic response. In particular, they highlight distributed set…

应用统计 · 统计学 2012-02-07 Gaël Varoquaux , Alexandre Gramfort , Jean Baptiste Poline , Bertrand Thirion

Identifying brain regions that exhibit altered functional connectivity across cognitive or emotional states is a key problem in neuroscience. Existing methods, such as edge-wise testing, seed-based psychophysiological interaction (PPI)…

统计方法学 · 统计学 2026-02-12 Shira Yoffe , Ziv Ben-Zion , Guy Gurevitch , Talma Hendler , Malka Gorfine , Ariel Jaffe

Functional connectivity, as estimated using resting state fMRI, has shown potential in bridging the gap between pathophysiology and cognition. However, clinical use of functional connectivity biomarkers is impeded by unreliable estimates of…

Brain Functional Networks (BFNs), graph theoretical models of brain activity data, provide a systems perspective of complex functional connectivity within the brain. Neurological disorders are known to have basis in abnormal functional…

定量方法 · 定量生物学 2016-08-30 Megha Singh , Rahul Badhwar , Ganesh Bagler

Functional connectivity (FC) studies have demonstrated the overarching value of studying the brain and its disorders through the undirected weighted graph of fMRI correlation matrix. Most of the work with the FC, however, depends on the way…

神经元与认知 · 定量生物学 2021-12-09 Usman Mahmood , Zening Fu , Vince Calhoun , Sergey Plis

In this work, we explore the state-space formulation of a network process to recover, from partial observations, the underlying network topology that drives its dynamics. To do so, we employ subspace techniques borrowed from system…

信号处理 · 电气工程与系统科学 2019-06-26 Mario Coutino , Elvin Isufi , Takanori Maehara , Geert Leus

Objective: Modelling the associations from high-throughput experimental molecular data has provided unprecedented insights into biological pathways and signalling mechanisms. Graphical models and networks have especially proven to be useful…

机器学习 · 统计学 2013-04-24 Marco Scutari , Radhakrishnan Nagarajan

We propose a method for gene expression based analysis of cancer phenotypes incorporating network biology knowledge through unsupervised construction of computational graphs. The structural construction of the computational graphs is driven…

Real-world networks often benefit from capturing both local and global interactions. Inspired by multi-modal analysis in brain imaging, where structural and functional connectivity offer complementary views of network organization, we…

神经与进化计算 · 计算机科学 2025-08-11 Yang Li , Luopeiwen Yi , Tananun Songdechakraiwut

Among the novel metrics used to study the relative importance of nodes in complex networks, k-core decomposition has found a number of applications in areas as diverse as sociology, proteinomics, graph visualization, and distributed system…

其他计算机科学 · 计算机科学 2011-03-30 Alberto Montresor , Francesco De Pellegrini , Daniele Miorandi

We introduce a mapping between graphs and pure quantum bipartite states and show that the associated entanglement entropy conveys non-trivial information about the structure of the graph. Our primary goal is to investigate the family of…

量子物理 · 物理学 2012-02-24 Silvano Garnerone , Paolo Giorda , Paolo Zanardi