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We propose a scalable semiparametric Bayesian model to capture dependencies among multiple neurons by detecting their co-firing (possibly with some lag time) patterns over time. After discretizing time so there is at most one spike at each…

应用统计 · 统计学 2015-06-22 Babak Shahbaba , Bo Zhou , Shiwei Lan , Hernando Ombao , David Moorman , Sam Behseta

Understanding the operation of biological and artificial networks remains a difficult and important challenge. To identify general principles, researchers are increasingly interested in surveying large collections of networks that are…

机器学习 · 统计学 2022-01-14 Alex H. Williams , Erin Kunz , Simon Kornblith , Scott W. Linderman

Synaptic plasticity depends on the interaction between electrical activity in neurons and the synaptic proteome, the collection of over 1000 proteins in the post-synaptic density (PSD) of synapses. To construct models of synaptic plasticity…

神经元与认知 · 定量生物学 2014-11-19 David C. Sterratt , Oksana Sorokina , J. Douglas Armstrong

In general, the behavior of large and complex aggregates of elementary components can not be understood nor extrapolated from the properties of a few components. The brain is a good example of this type of networked systems where some…

混沌动力学 · 物理学 2012-08-02 Ricardo Lopez-Ruiz , Daniele Fournier-Prunaret

Biological networks exhibit complex, coordinated patterns of activity. Can these patterns be captured precisely in simple models? Here we use measurements of simultaneous activity in 1000+ neurons in the mouse brain to test the validity of…

生物物理 · 物理学 2023-04-27 Leenoy Meshulam , Jeffrey L. Gauthier , Carlos D. Brody , David W. Tank , William Bialek

This paper explores the impact of biologically plausible neuron models on the performance of Spiking Neural Networks (SNNs) for regression tasks. While SNNs are widely recognized for classification tasks, their application to Scientific…

数值分析 · 数学 2024-01-02 Mario De Florio , Adar Kahana , George Em Karniadakis

Deep neural networks often develop spurious bias, reliance on correlations between non-essential features and classes for predictions. For example, a model may identify objects based on frequently co-occurring backgrounds rather than…

机器学习 · 计算机科学 2025-06-02 Guangtao Zheng , Wenqian Ye , Aidong Zhang

Large language models often fail on tasks they seem to already understand. In our experiments, this appears to be less about missing knowledge and more about certain internal circuits not being strongly activated during inference. We…

机器学习 · 计算机科学 2026-05-12 Ryyan Akhtar , Payal Pahwa , Monika Arora

Deep brain stimulation(DBS)has become an effective intervention for advanced Parkinson's disease, but the exact mechanism of DBS is still unclear. In this review, we discuss the history of DBS, the anatomy and internal architecture of the…

神经元与认知 · 定量生物学 2023-03-24 Yongtong Wu , Kejia Hu , Shenquan Liu

We describe a procedure for explaining neurons in deep representations by identifying compositional logical concepts that closely approximate neuron behavior. Compared to prior work that uses atomic labels as explanations, analyzing neurons…

机器学习 · 计算机科学 2021-02-04 Jesse Mu , Jacob Andreas

Large-scale neuroscience is generating rich datasets across animals, brain areas and behavioral contexts, yet our modeling efforts remains fragmented across isolated experiments. We argue that understanding behavior requires integrative…

It takes several years for the developing brain of a baby to fully master word repetition-the task of hearing a word and repeating it aloud. Repeating a new word, such as from a new language, can be a challenging task also for adults.…

计算与语言 · 计算机科学 2025-06-17 Daniel Dager , Robin Sobczyk , Emmanuel Chemla , Yair Lakretz

Many models used in artificial intelligence and cognitive science rely on multi-element patterns stored in "slots" - dedicated storage locations - in a digital computer. As biological brains likely lack slots, we consider how they might…

神经与进化计算 · 计算机科学 2025-11-07 Shaunak Bhandarkar , James L. McClelland

Many recent efforts in computational modeling of macro-scale brain dynamics have begun to take a data-driven approach by incorporating structural and/or functional information derived from subject data. Here, we discuss recent work using…

神经元与认知 · 定量生物学 2018-11-15 Kanika Bansal , Johan Nakuci , Sarah Feldt Muldoon

This article addresses reaction networks in which spatial and stochastic effects are of crucial importance. For such systems, particle-based models allow us to describe all microscopic details with high accuracy. However, they suffer from…

Neuro-inspired models and systems have great potential for applications in unconventional computing. Often, the mechanisms of biological neurons are modeled or mimicked in simulated or physical systems in an attempt to harness some of the…

神经与进化计算 · 计算机科学 2021-10-18 Jørgen Jensen Farner , Håkon Weydahl , Ruben Jahren , Ola Huse Ramstad , Stefano Nichele , Kristine Heiney

One conjecture in both deep learning and classical connectionist viewpoint is that the biological brain implements certain kinds of deep networks as its back-end. However, to our knowledge, a detailed correspondence has not yet been set up,…

人工智能 · 计算机科学 2013-01-29 Louis Yuanlong Shao

Structured neuron encapsulation introduces a modular framework that enables more effective aggregation and specialization of information within deep learning architectures. A model modified through this framework demonstrated improved…

The growing interest in brain-inspired computational models arises from the remarkable problem-solving efficiency of the human brain. Action recognition, a complex task in computational neuroscience, has received significant attention due…

神经与进化计算 · 计算机科学 2024-06-18 Alireza Nadafian , Milad Mozafari , Timothée Masquelier , Mohammad Ganjtabesh

Modeling of biomolecular systems plays an essential role in understanding biological processes, such as ionic flow across channels, protein modification or interaction, and cell signaling. The continuum model described by the…

生物物理 · 物理学 2015-12-08 Yu Qiao , Benzhuo Lu