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The reaction-diffusion master equation (RDME) is a lattice stochastic reaction-diffusion model that has been used to study spatially distributed cellular processes. The RDME is often interpreted as an approximation to spatially-continuous…

数值分析 · 数学 2013-08-05 Samuel A Isaacson

The reaction-diffusion master equation (RDME) is commonly used to model processes where both the spatial and stochastic nature of chemical reactions need to be considered. We show that the RDME in many cases is inconsistent with a…

定量方法 · 定量生物学 2009-05-29 Paul Sjoberg , Otto G Berg , Johan Elf

The convergent reaction-diffusion master equation (CRDME) was recently developed to provide a lattice particle-based stochastic reaction-diffusion model that is a convergent approximation in the lattice spacing to an underlying…

数值分析 · 数学 2018-08-14 Samuel A. Isaacson , Ying Zhang

The chemical diffusion master equation (CDME) describes the probabilistic dynamics of reaction--diffusion systems at the molecular level [del Razo et al., Lett. Math. Phys. 112:49, 2022]; it can be considered the master equation for…

统计力学 · 物理学 2023-01-23 Mauricio J. del Razo , Stefanie Winkelmann , Rupert Klein , Felix Höfling

The reaction-diffusion master equation (RDME) is a lattice-based stochastic model for spatially resolved cellular processes. It is often interpreted as an approximation to spatially continuous reaction-diffusion models, which, in the limit…

统计力学 · 物理学 2022-01-11 Alberto Montefusco , Christof Schütte , Stefanie Winkelmann

The reaction-diffusion master equation (RDME) is a standard modelling approach for understanding stochastic and spatial chemical kinetics. An inherent assumption is that molecules are point-like. Here we introduce the crowded…

统计力学 · 物理学 2016-03-23 Claudia Cianci , Stephen Smith , Ramon Grima

Stochastic modeling of reaction-diffusion kinetics has emerged as a powerful theoretical tool in the study of biochemical reaction networks. Two frequently employed models are the particle-tracking Smoluchowski framework and the on-lattice…

数值分析 · 数学 2012-04-27 Stefan Hellander , Andreas Hellander , Linda Petzold

We develop a convergent reaction-drift-diffusion master equation (CRDDME) to facilitate the study of reaction processes in which spatial transport is influenced by drift due to one-body potential fields within general domain geometries. The…

数值分析 · 数学 2025-01-22 Samuel A. Isaacson , Ying Zhang

The mesoscopic reaction-diffusion master equation (RDME) is a popular modeling framework, frequently applied to stochastic reaction-diffusion kinetics in systems biology. The RDME is derived from assumptions about the underlying physical…

数值分析 · 数学 2015-06-23 Stefan Hellander , Andreas Hellander , Linda Petzold

Many biological activities are induced by cellular chemical reactions of diffusing reactants. The dynamics of such systems can be captured by stochastic reaction networks. A recent numerical study has shown that diffusion can significantly…

生物物理 · 物理学 2019-01-18 Tan Van Vu , Yoshihiko Hasegawa

The multi-grid reaction-diffusion master equation (mgRDME) provides a generalization of stochastic compartment-based reaction-diffusion modelling described by the standard reaction-diffusion master equation (RDME). By enabling different…

定量方法 · 定量生物学 2024-05-06 Radek Erban , Stefanie Winkelmann

The stochastic nature of chemical reactions involving randomly fluctuating population sizes has lead to a growing research interest in discrete-state stochastic models and their analysis. A widely-used approach is the description of the…

定量方法 · 定量生物学 2015-10-01 Alexander Andreychenko , Luca Bortolussi , Ramon Grima , Philipp Thomas , Verena Wolf

The modeling and simulation of stochastic reaction-diffusion processes is a topic of steady interest that is approached with a wide range of methods. \rev{At the level of particle-resolved descriptions, where chemical reactions are coupled…

Stochastic chemical systems with diffusion are modeled with a reaction-diffusion master equation. On a macroscopic level, the governing equation is a reaction-diffusion equation for the averages of the chemical species. On a mesoscopic…

数值分析 · 数学 2009-03-06 Stefan Engblom , Lars Ferm , Andreas Hellander , Per Lötstedt

The reaction-diffusion master equation (RDME) is a model that allows for efficient on-lattice simulation of spatially resolved stochastic chemical kinetics. Compared to off-lattice hard-sphere simulations with Brownian Dynamics (BD) or…

数值分析 · 数学 2017-09-06 Stefan Hellander , Andreas Hellander , Linda Petzold

The reaction-diffusion master equation is a stochastic model often utilized in the study of biochemical reaction networks in living cells. It is applied when the spatial distribution of molecules is important to the dynamics of the system.…

数值分析 · 数学 2017-03-08 Stefan Hellander , Linda Petzold

To model bio-chemical reaction systems with diffusion one can either use stochastic, microscopic reaction-diffusion master equations or deterministic, macroscopic reaction-diffusion system. The connection between these two models is not…

偏微分方程分析 · 数学 2023-06-21 Malcolm Egan , Bao Quoc Tang

In synaptic molecular communication, the activation of postsynaptic receptors by neurotransmitters (NTs) is governed by a stochastic reaction-diffusion process and, hence, inherently random. It is currently not fully understood how this…

新兴技术 · 计算机科学 2023-01-18 Sebastian Lotter , Maximilian Schäfer , Robert Schober

We consider molecular communication networks consisting of transmitters and receivers distributed in a fluidic medium. In such networks, a transmitter sends one or more signalling molecules, which are diffused over the medium, to the…

计算工程、金融与科学 · 计算机科学 2015-03-20 Chun Tung Chou

The discrete chemical master equation (dCME) provides a fundamental framework for studying stochasticity in mesoscopic networks. Because of the multi-scale nature of many networks where reaction rates have large disparity, directly solving…

定量方法 · 定量生物学 2017-07-27 Youfang Cao , Anna Terebus , Jie Liang
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