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In functional MRI (fMRI), effective connectivity analysis aims at inferring the causal influences that brain regions exert on one another. A common method for this type of analysis is structural equation modeling (SEM). We here propose a…

定量方法 · 定量生物学 2024-09-10 G. Marrelec , A. Giron

Understanding the human brain remains the Holy Grail in biomedical science, and arguably in all of the sciences. Our brains represent the most complex systems in the world (and some contend the universe) comprising nearly one hundred…

定量方法 · 定量生物学 2016-02-03 Sean L. Simpson , Paul J. Laurienti

Neuroimaging data can be represented as networks of nodes and edges that capture the topological organization of the brain connectivity. Graph theory provides a general and powerful framework to study these networks and their structure at…

神经元与认知 · 定量生物学 2017-05-19 Cécile Bordier , Carlo Nicolini , Angelo Bifone

Understanding the evolution of brain functional networks over time is of great significance for the analysis of cognitive mechanisms and the diagnosis of neurological diseases. Existing methods often have difficulty in capturing the…

机器学习 · 计算机科学 2025-10-30 Tianqi Guo , Liping Chen , Ciyuan Peng , Jingjing Zhou , Jing Ren

A central question in neuroscience is how self-organizing dynamic interactions in the brain emerge on their relatively static structural backbone. Due to the complexity of spatial and temporal dependencies between different brain areas,…

Multiple-subject network data are fast emerging in recent years, where a separate connectivity matrix is measured over a common set of nodes for each individual subject, along with subject covariates information. In this article, we propose…

统计方法学 · 统计学 2021-03-23 Jingfei Zhang , Will Wei Sun , Lexin Li

Whole-brain neural connectivity data are now available from viral tracing experiments, which reveal the connections between a source injection site and elsewhere in the brain. These hold the promise of revealing spatial patterns of…

神经元与认知 · 定量生物学 2016-10-27 Kameron Decker Harris , Stefan Mihalas , Eric Shea-Brown

Comprehending the interplay between spatial and temporal characteristics of neural dynamics can contribute to our understanding of information processing in the human brain. Graph neural networks (GNNs) provide a new possibility to…

神经元与认知 · 定量生物学 2022-04-29 Simon Wein , Alina Schüller , Ana Maria Tomé , Wilhelm M. Malloni , Mark W. Greenlee , Elmar W. Lang

The theory of random graphs is being applied in recent years to model neural interactions in the brain. While the probabilistic properties of random graphs has been extensively studied in the literature, the development of statistical…

应用统计 · 统计学 2015-04-27 Andressa Cerqueira , Daniel Fraiman , Claudia D. Vargas , Florencia Leonardi

Modeling the behavior of coupled networks is challenging due to their intricate dynamics. For example in neuroscience, it is of critical importance to understand the relationship between the functional neural processes and anatomical…

机器学习 · 计算机科学 2021-04-20 Hongyuan You , Sikun Lin , Ambuj K. Singh

Many complex systems - be they financial, natural, or social - are composed of units - such as stocks, neurons, or agents - whose joint activity can be represented as a multivariate time series. An issue of both practical and theoretical…

The field of hypothesis generation promises to reduce costs in neuroscience by narrowing the range of interventional studies needed to study various phenomena. Existing machine learning methods can generate scientific hypotheses from…

机器学习 · 计算机科学 2025-07-04 Zachary C. Brown , David Carlson

Functional connectivity analysis is an important tool for characterizing interactions among brain regions, particularly in studies of neurodegenerative disorders such as Alzheimer's disease (AD). Gaussian graphical models (GGMs) provide a…

统计方法学 · 统计学 2026-04-14 Panpan Zhang , Shiying Xiao , W. Hudson Robb , Dandan Liu , Angela L. Jefferson , Jun Yan

Functional connectivity of cognitive tasks allows researchers to analyse the interaction mapping occurring between different regions of the brain using electroencephalography (EEG) signals. Standard practice in functional connectivity…

人机交互 · 计算机科学 2019-07-23 Saugat Bhattacharyya , Mitsuhiro Hayashibe

The adjacency matrix is the most fundamental and intuitive object in graph analysis that is useful not only mathematically but also for visualizing the structures of graphs. Because the appearance of an adjacency matrix is critically…

社会与信息网络 · 计算机科学 2023-04-07 Tatsuro Kawamoto , Teruyoshi Kobayashi

We propose a Bayesian framework for uncertainty quantification and comparison in brain connectivity graph analysis. Standard graph-based approaches typically rely on point estimates of correlation matrices, overlooking the uncertainty…

统计方法学 · 统计学 2026-05-29 Alice Chevaux , Julyan Arbel , Guillaume Kon Kam King , Sophie Achard

While statistical analysis of a single network has received a lot of attention in recent years, with a focus on social networks, analysis of a sample of networks presents its own challenges which require a different set of analytic tools.…

统计方法学 · 统计学 2019-10-23 Jesús D. Arroyo-Relión , Daniel Kessler , Elizaveta Levina , Stephan F. Taylor

The estimation of causal network architectures in the brain is fundamental for understanding cognitive information processes. However, access to the dynamic processes underlying cognition is limited to indirect measurements of the hidden…

神经元与认知 · 定量生物学 2020-08-17 H. C. Ruiz-Euler , H. J. Kappen

Outstanding achievements of graph neural networks for spatiotemporal time series analysis show that relational constraints introduce an effective inductive bias into neural forecasting architectures. Often, however, the relational…

机器学习 · 计算机科学 2023-08-03 Andrea Cini , Daniele Zambon , Cesare Alippi

Whole-brain network analyses remain the vanguard in neuroimaging research, coming to prominence within the last decade. Network science approaches have facilitated these analyses and allowed examining the brain as an integrated system.…

应用统计 · 统计学 2015-05-04 Sean L. Simpson , Paul J. Laurienti