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Language models, especially transformer-based ones, have achieved colossal success in NLP. To be precise, studies like BERT for NLU and works like GPT-3 for NLG are very important. If we consider DNA sequences as a text written with an…

基因组学 · 定量生物学 2026-01-21 Musa Nuri Ihtiyar , Arzucan Ozgur

We characterize the meaning of words with language-independent numerical fingerprints, through a mathematical analysis of recurring patterns in texts. Approximating texts by Markov processes on a long-range time scale, we are able to…

计算与语言 · 计算机科学 2022-02-07 Weinan E , Yajun Zhou

This thesis investigates how the sub-structure of words can be accounted for in probabilistic models of language. Such models play an important role in natural language processing tasks such as translation or speech recognition, but often…

计算与语言 · 计算机科学 2015-08-19 Jan A. Botha

When we speak, write or listen, we continuously make predictions based on our knowledge of a language's grammar. Remarkably, children acquire this grammatical knowledge within just a few years, enabling them to understand and generalise to…

计算与语言 · 计算机科学 2024-11-26 Jaap Jumelet

This paper presents a novel method to segment/decode DNA sequences based on n-grams statistical language model. Firstly, we find the length of most DNA 'words' is 12 to 15 bps by analyzing the genomes of 12 model species. Then we design an…

基因组学 · 定量生物学 2015-03-13 Wang Liang

Since the completion of the human genome sequencing project in 2001, significant progress has been made in areas such as gene regulation editing and protein structure prediction. However, given the vast amount of genomic data, the segments…

其他定量生物学 · 定量生物学 2025-01-29 Wang Liang

We introduce a method to estimate the complexity function of symbolic dynamical systems from a finite sequence of symbols. We test such complexity estimator on several symbolic dynamical systems whose complexity functions are known exactly.…

种群与进化 · 定量生物学 2017-01-19 R. Salgado-Garcia , E. Ugalde

Codes have been used for centuries to convey secret information.To a cryptanalyst, the interception of a code is only the first step in recovering a secret message.Deoxyribonucleic acid (DNA) is a biological and molecular code.Through the…

密码学与安全 · 计算机科学 2008-01-31 O. Okunoye Babatunde

Molecular biology is a nanotechnology that works--it has worked for billions of years and in an amazing variety of circumstances. At its core is a system for acquiring, processing and communicating information that is universal, from…

基因组学 · 定量生物学 2016-12-21 Apoorva D. Patel

We propose a new statistical model for computational linguistics. Rather than trying to estimate directly the probability distribution of a random sentence of the language, we define a Markov chain on finite sets of sentences with many…

机器学习 · 统计学 2013-02-12 Olivier Catoni , Thomas Mainguy

Language enables humans to share knowledge, reason about the world, and pass on strategies for survival and innovation across generations. At the heart of this process is not just the ability to communicate but also the remarkable…

计算与语言 · 计算机科学 2026-02-25 Jan Philip Wahle

Autoregressive language models achieve remarkable performance, yet a unified theory explaining their internal mechanisms, how training shapes representations, and why these representations support complex behavior remains incomplete. We…

机器学习 · 计算机科学 2026-05-14 Yifan Zhang

Chain-of-Thought (CoT) reasoning often fails to faithfully reflect a language model's underlying decision process. We address this by introducing a Markovian language model framework with an autoencoder-style reasoning bottleneck: all…

计算与语言 · 计算机科学 2026-03-11 Scott Viteri , Max Lamparth , Peter Chatain , Clark Barrett

The yearly global production of data is growing exponentially, outpacing the capacity of existing storage media, such as tape and disk, and surpassing our ability to store it. DNA storage - the representation of arbitrary information as…

定量方法 · 定量生物学 2023-10-04 Thomas Heinis , Roman Sokolovskii , Jamie J. Alnasir

A general theoretical framework is put forth to organize and understand various observed phenomena and mathematical relationships in the field of molecular biology. By modeling each cell in eukaryotic organisms as a processor having a…

其他定量生物学 · 定量生物学 2013-12-18 Barry D. Jacobson

Studying characters plays a vital role in computationally representing and interpreting narratives. Unlike previous work, which has focused on inferring character roles, we focus on the problem of modeling their relationships. Rather than…

计算与语言 · 计算机科学 2015-12-01 Snigdha Chaturvedi , Shashank Srivastava , Hal Daume , Chris Dyer

The evolution in coding DNA sequences brings new flexibility and freedom to the codon words, even as the underlying nucleotides get significantly ordered. These curious contra-rules of gene organisation are observed from the distribution of…

生物物理 · 物理学 2007-05-23 Sujay Chattopadhyay , William A. Kanner , Jayprokas Chakrabarti

Written language is a complex communication signal capable of conveying information encoded in the form of ordered sequences of words. Beyond the local order ruled by grammar, semantic and thematic structures affect long-range patterns in…

物理与社会 · 物理学 2010-05-17 Marcelo A. Montemurro , Damian Zanette

Next Generation Sequencing (NGS) technologies generate large amounts of short read data for many different organisms. The fact that NGS reads are generally short makes it challenging to assemble the reads and reconstruct the original genome…

基因组学 · 定量生物学 2015-04-07 Jie Ren , Kai Song , Minghua Deng , Gesine Reinert , Charles H. Cannon , Fengzhu Sun

DNA language models are increasingly used to represent genomic sequence, yet their effectiveness depends critically on how raw nucleotides are converted into model inputs. Unlike natural language, DNA offers no canonical boundaries, making…

基因组学 · 定量生物学 2026-05-21 Taewon Kim , Jihwan Shin , Hyomin Kim , Youngmok Jung , Jonghoon Lee , Won-Chul Lee , Sungsoo Ahn , Insu Han
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