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The conformational kinetics of enzymes can be reliably revealed when they are governed by Markovian dynamics. Hidden Markov Models (HMMs) are appropriate especially in the case of conformational states that are hardly distinguishable.…

定量方法 · 定量生物学 2009-02-05 A. Kovalev , N. Zarrabi , F. Werz , M. Boersch , Z. Ristic , H. Lill , D. Bald , C. Tietz , J. Wrachtrup

The Expectation-Maximization (EM) algorithm is a fundamental tool in unsupervised machine learning. It is often used as an efficient way to solve Maximum Likelihood (ML) estimation problems, especially for models with latent variables. It…

量子物理 · 物理学 2020-07-08 Iordanis Kerenidis , Alessandro Luongo , Anupam Prakash

Motivated by high-throughput single-cell cytometry data with applications to vaccine development and immunological research, we consider statistical clustering in large-scale data that contain multiple rare clusters. We propose a new…

统计方法学 · 统计学 2016-06-30 Lin Lin , Jia Li

We show that density models describing multiple observables with (i) hard boundaries and (ii) dependence on external parameters may be created using an auto-regressive Gaussian mixture model. The model is designed to capture how observable…

数据分析、统计与概率 · 物理学 2022-02-01 Stephen B. Menary , Darren D. Price

We demonstrate the application of pattern recognition algorithms via hidden Markov models (HMM) for qubit readout. This scheme provides a state-path trajectory approach capable of detecting qubit state transitions and makes for a robust…

量子物理 · 物理学 2021-01-04 Luis A. Martinez , Yaniv J. Rosen , Jonathan L. DuBois

We present a machine learning (ML)-assisted framework bridging manifold learning, neural networks, Gaussian processes, and Equation-Free multiscale modeling, for (a) detecting tipping points in the emergent behavior of complex systems, and…

Standard Gaussian graphical models (GGMs) implicitly assume that the conditional independence among variables is common to all observations in the sample. However, in practice, observations are usually collected form heterogeneous…

统计方法学 · 统计学 2010-01-26 Abel Rodriguez , Alex Lenkoski , Adrian Dobra

In this project, we first study the Gaussian-based hidden Markov random field (HMRF) model and its expectation-maximization (EM) algorithm. Then we generalize it to Gaussian mixture model-based hidden Markov random field. The algorithm is…

计算机视觉与模式识别 · 计算机科学 2012-12-20 Quan Wang

State-space models (SSMs) are commonly used to model time series data where the observations depend on an unobserved latent process. However, inference on the model parameters of an SSM can be challenging, especially when the likelihood of…

统计计算 · 统计学 2023-08-08 Mary Llewellyn , Ruth King , Víctor Elvira , Gordon Ross

This report introduces a parsimonious structure for mixture of autoregressive models, where the weighting coefficients are determined through latent random variables as functions of all past observations. These variables follow a hidden…

统计理论 · 数学 2011-05-17 S. H. Alizadeh , S. Rezakhah

We present a novel algorithm for learning the parameters of hidden Markov models (HMMs) in a geometric setting where the observations take values in Riemannian manifolds. In particular, we elevate a recent second-order method of moments…

机器学习 · 计算机科学 2023-02-16 Berlin Chen , Cyrus Mostajeran , Salem Said

Continuous space species distribution models (SDMs) have a long-standing history as a valuable tool in ecological statistical analysis. Geostatistical and preferential models are both common models in ecology. Geostatistical models are…

应用统计 · 统计学 2023-07-17 Mario Figueira , David Conesa , Antonio López-Quílez , Iosu Paradinas

Hidden Markov Models (HMMs) comprise a powerful generative approach for modeling sequential data and time-series in general. However, the commonly employed assumption of the dependence of the current time frame to a single or multiple…

机器学习 · 计算机科学 2021-09-13 Konstantinos P. Panousis , Sotirios Chatzis , Sergios Theodoridis

State-space models (SSMs) are a popular tool for modeling animal abundances. Inference difficulties for simple linear SSMs are well known, particularly in relation to simultaneous estimation of process and observation variances. Several…

种群与进化 · 定量生物学 2019-09-20 Leo Polansky , Ken B. Newman , Lara Mitchell

This work studies the class of algorithms for learning with side-information that emerge by extending generative models with embedded context-related variables. Using finite mixture models (FMM) as the prototypical Bayesian network, we show…

机器学习 · 统计学 2020-08-17 Serafeim Perdikis , Robert Leeb , Ricardo Chavarriaga , José del R. Millán

The hidden Markov model (HMM) is a widely-used generative model that copes with sequential data, assuming that each observation is conditioned on the state of a hidden Markov chain. In this paper, we derive a novel algorithm to cluster HMMs…

机器学习 · 计算机科学 2012-10-26 Emanuele Coviello , Antoni B. Chan , Gert R. G. Lanckriet

In pursuit of explainability, we develop generative models for sequential data. The proposed models provide state-of-the-art classification results and robust performance for speech phone classification. We combine modern neural networks…

机器学习 · 计算机科学 2021-07-05 Anubhab Ghosh , Antoine Honoré , Dong Liu , Gustav Eje Henter , Saikat Chatterjee

Stochastic dynamical systems arise naturally across nearly all areas of science and engineering. Typically, a dynamical system model is based on some prior knowledge about the underlying dynamics of interest in which probabilistic features…

计算工程、金融与科学 · 计算机科学 2021-09-03 Chao Yin , Xihaier Luo , Ahsan Kareem

We present a new subspace-based method to construct probabilistic models for high-dimensional data and highlight its use in anomaly detection. The approach is based on a statistical estimation of probability density using densities of…

机器学习 · 计算机科学 2021-08-16 Cetin Savkli , Catherine Schwartz

We propose a framework to model the distribution of sequential data coming from a set of entities connected in a graph with a known topology. The method is based on a mixture of shared hidden Markov models (HMMs), which are jointly trained…

机器学习 · 计算机科学 2019-04-02 Diogo Pernes , Jaime S. Cardoso