相关论文: Near-optimal RNA-Seq quantification

The task of RNA design given a target structure aims to find a sequence that can fold into that structure. It is a computationally hard problem where some version(s) have been proven to be NP-hard. As a result, heuristic methods such as…

Isoform quantification is an important goal of RNA-seq experiments, yet it remains prob- lematic for genes with low expression or several isoforms. These difficulties may in principle be ameliorated by exploiting correlated experimental…

Existing state-of-the-art methods that take a single RNA sequence and predict the corresponding RNA secondary-structure are thermodynamic methods. These predict the most stable RNA structure, but do not consider the process of structure…

Single-cell RNA sequencing (scRNA-seq) is powerful technology that allows researchers to understand gene expression patterns at the single-cell level. However, analysing scRNA-seq data is challenging due to issues and biases in data…

We study the estimation of repeatedly nested expectations (RNEs) with a constant horizon (number of nestings) using quantum computing. We propose a quantum algorithm that achieves $\varepsilon$-error with cost $\tilde O(\varepsilon^{-1})$,…

Real-time PCR, or Real-time Quantitative PCR (qPCR) is an effective approach to quantify nucleic acid samples. Given the complicated reaction system along with thermal cycles, there has been long-term confusion on accurately calculating the…

By combining various cancer cell line (CCL) drug screening panels, the size of the data has grown significantly to begin understanding how advances in deep learning can advance drug response predictions. In this paper we train >35,000…

Quantization is a widely used compression method that effectively reduces redundancies in over-parameterized neural networks. However, existing quantization techniques for deep neural networks often lack a comprehensive error analysis due…

This paper describes a new method for low rank kernel approximation called IKA. The main advantage of IKA is that it produces a function $\psi(x)$ defined as a linear combination of arbitrarily chosen functions. In contrast the…

The Nystr\"om method is a convenient heuristic method to obtain low-rank approximations to kernel matrices in nearly linear complexity. Existing studies typically use the method to approximate positive semidefinite matrices with low or…

Program optimization is the process of modifying software to execute more efficiently. Superoptimizers attempt to find the optimal program by employing significantly more expensive search and constraint solving techniques. Generally, these…

Seeking the equivalent entities among multi-source Knowledge Graphs (KGs) is the pivotal step to KGs integration, also known as \emph{entity alignment} (EA). However, most existing EA methods are inefficient and poor in scalability. A…

Superconducting qubits are among the most promising candidates for building quantum information processors. Yet, they are often limited by slow and error-prone qubit readout -- a critical factor in achieving high-fidelity operations. While…

DNA methylation (DNAme) is a critical component of the epigenetic regulatory machinery and aberrations in DNAme patterns occur in many diseases, such as cancer. Mapping and understanding DNAme profiles offers considerable promise for…

Kernel Density Estimation (KDE) is a nonparametric method for estimating the shape of a density function, given a set of samples from the distribution. Recently, locality-sensitive hashing, originally proposed as a tool for nearest neighbor…

Recent convolutional neural network (CNN) development continues to advance the state-of-the-art model accuracy for various applications. However, the enhanced accuracy comes at the cost of substantial memory bandwidth and storage…

Sequence Alignment is the process of aligning biological sequences in order to identify similarities between multiple sequences. In this paper, a Quantum Algorithm for finding the optimal alignment between DNA sequences has been…

There is a constant need for high-performing and computationally efficient neural network models for image super-resolution: computationally efficient models can be used via low-capacity devices and reduce carbon footprints. One way to…

Quantizing deep neural networks is an effective method for reducing memory consumption and improving inference speed, and is thus useful for implementation in resource-constrained devices. However, it is still hard for extremely low-bit…

Deep neural networks (DNNs) have achieved great success in a wide range of computer vision areas, but the applications to mobile devices is limited due to their high storage and computational cost. Much efforts have been devoted to compress…