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Host-guest binding plays a crucial role in the functionality of various systems, and its efficiency is often quantified using the binding free energy, which represents the free-energy difference between the bound and dissociated states.…

化学物理 · 物理学 2025-01-03 Kazuya Okita , Yusei Maruyama , Kento Kasahara , Nobuyuki Matubayasi

Electro-energy-reaction-diffusion systems are thermodynamically consistent continuum models for reaction-diffusion processes that account for temperature and electrostatic effects in a way that total charge and energy are conserved. The…

偏微分方程分析 · 数学 2026-04-09 Katharina Hopf , Michael Kniely , Alexander Mielke

Most methods for estimating configurational entropy from molecular simulation data yield upper limits except for harmonic systems where they are exact. Problems arise at diffusive systems and the presence of conformational transitions.…

化学物理 · 物理学 2019-10-22 Jürgen Schlitter , Matthias Massarczyk

Integral equation theory of molecular liquids based on statistical mechanics is quite promising as an essential part of multiscale methodology for chemical and biomolecular nanosystems in solution. Beginning with a molecular interaction…

软凝聚态物质 · 物理学 2015-10-23 A. Kovalenko

The high-energy tail of the distribution of solute-solvent interaction energies is poorly characterized for condensed systems, but this tail region is of principal interest in determining the excess free energy of the solute. We introduce…

化学物理 · 物理学 2015-05-28 Valery Weber , Safir Merchant , D. Asthagiri

A recently developed statistical mechanical Quasi-Chemical Theory (QCT) has led to significant insights into solvation phenomena for both hydrophilic and hydrophobic solutes. The QCT exactly partitions solvation free energies into three…

统计力学 · 物理学 2009-11-13 David M. Rogers , Thomas L. Beck

The thesis focuses on the prediction of solvation thermodynamics using integral equation theories. Our main goal is to improve the approach using a rational correction. We achieve it by extending recently introduced pressure correction, and…

化学物理 · 物理学 2017-04-19 Maksim Misin

Solvation effect might have a tremendous influence on chemical reactions. However, precise quantum chemistry calculations are most often done either in vacuum neglecting the role of the solvent or using continuum solvent model ignoring its…

化学物理 · 物理学 2020-07-14 Guillaume Jeanmairet , Maximilien Levesque , Daniel Borgis

The concept of the effective one-electron potentials (OEP) has been useful for many decades in efficient description of electronic structure of chemical systems, especially extended molecular aggregates such as interacting molecules in…

化学物理 · 物理学 2020-02-04 Bartosz Błasiak , Joanna D. Bednarska , Marta Chołuj , Wojciech Bartkowiak

For theories plagued with a sign problem at finite density, a Taylor expansion in the chemical potential is frequently used for lattice gauge theory based computations of the equation of state. Recently, in arXiv:2106.03165, a new…

高能物理 - 唯象学 · 物理学 2022-03-30 Swagato Mukherjee , Fabian Rennecke , Vladimir V. Skokov

The entropies of molecules in solution are routinely calculated using gas phase formulae. It is assumed that, because implicit solvation models are fitted to reproduce free energies, this is sufficient for modeling reactions in solution.…

化学物理 · 物理学 2019-02-01 Alejandro J. Garza

The usual strategy for deducing the $\pi\mbox{--}\pi^\ast$ electronic energy (or optical bandgap) in a molecule with an "infinite" number of conjugated double bonds consists in fitting a function with some adjustable parameters to the…

材料科学 · 物理学 2015-12-18 K. Razi Naqvi

Using the entropy $S$ as a reaction coordinate, we determine the free energy barrier associated with the formation of a liquid droplet from a supersaturated vapor for atomic and molecular fluids. For this purpose, we develop the $\mu VT-S$…

统计力学 · 物理学 2021-08-25 Caroline Desgranges , Jerome Delhommelle

We have derived a new method which allows to compute the full and the Pauli reference kinetic potentials for atoms and molecules in a real space representation. This is done by applying the optimized effective potential (OEP) method to…

化学物理 · 物理学 2020-05-08 Szymon Śmiga , Sylwia Siecińska , Eduardo Fabiano

In this work, we present Enhanced Representation-Based Sampling (ERBS), a novel enhanced sampling method designed to generate structurally diverse training datasets for machine-learned interatomic potentials. ERBS automatically identifies…

化学物理 · 物理学 2026-01-23 Moritz René Schäfer , Johannes Kästner

This work presents a rigorous statistical mechanical theory of solvation free energies, specifically useful for describing the long-range nature of ions in an electrolyte solution. The theory avoids common issues with field theories by…

统计力学 · 物理学 2017-12-29 David M. Rogers

On the basis of the extended classical elasticity theory, we propose universal semi-empirical analytical expressions for the energy and the equation of state for poly-crystalline solids. The validation of the relations has been made by…

材料科学 · 物理学 2026-05-18 O. Bystrenko , B. Ilkiv , S. Petrovska , T. Bystrenko , O. Foia , O. Khyzhun

We derive the representation of the nonequilibrium steady-state distribution function which is expressed in terms of the excess free energy production. This representation resembles the one derived recently by Komatsu and Nakagawa [Phys.…

统计力学 · 物理学 2015-05-18 Song-Ho Chong , Michio Otsuki , Hisao Hayakawa

The energy density functional (EDF) method is currently the only microscopic theoretical approach able to tackle the entire nuclear chart. Nevertheless, it suffers from limitations resulting from its empirical character and deteriorating…

核理论 · 物理学 2024-04-04 Kilian Fraboulet , Jean-Paul Ebran

We propose an enhanced approach to the extrapolation of mean potential forces acting on atoms of solute macromolecules due to their interactions with solvent atoms in complex biochemical liquids. It improves and extends previous…

化学物理 · 物理学 2020-01-08 Igor Omelyan , Andriy Kovalenko
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