相关论文: Patterned and Functionalized Nanofiber Scaffolds i…
Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of…
Biomaterials are becoming an essential tool in the study and application of stem cell research. Various types of biomaterials enable three-dimensional (3D) culture of stem cells, and, more recently, also enable high-resolution patterning…
Unlike other tissue types, the nervous tissue extends to a wide and complex environment that provides a plurality of different biochemical and topological stimuli which in turn define the functions of that tissue. As a consequence of such…
In tissue engineering, we seek to address comprehensive tissue repair and regeneration needs. Aligned nanofibers have emerged as powerful and versatile tools, attributable to their structural and biochemical congruence with the natural…
Designing synthetic microenvironments for cellular investigations is a very active area of research at the crossroads of cell biology and materials science. The present work describes the design and functionalization of a three-dimensional…
When materials are patterned in three dimensions, there exist opportunities to tailor and create functionalities associated with an increase in complexity, the breaking of symmetries, and the introduction of curvature and non-trivial…
Neural interfaces using biocompatible scaffolds provide crucial properties for the functional repair of nerve injuries and neurodegenerative diseases, including cell adhesion, structural support, and mass transport. Neural stimulation has…
Hierarchical biomaterials embody nature's intricate design principles, offering advanced functionalities through the complex, multi-level organization of their molecular and nanosized building blocks. However, the comprehensive…
We report on a novel dual-structure scaffold fabricated using two-photon polymerisation (2PP), integrating electrically conductive and non-conductive regions within a single architecture, targeting neural tissue regeneration. Poly(ethylene…
People with injuries to the peripheral nervous system, due to its poor functional regeneration, suffer from paralysis of the facial muscles, fingers and hands, or toes and feet, often for the rest of their lives. Therefore, to improve…
Nanothreads are 1D carbon-based nanomaterials produced by pressure-induced polymerization of multiply unsaturated (and typically aromatic) precursors with multiple bonds between adjacent precursors. We computationally design non-covalent…
Three-dimensional (3D) magnetic nanostructures offer unprecedented opportunities for engineering emergent spin textures, but controlling their configuration remains a central challenge. Here we show that conformally coated Ni Nanotubes…
The scientific community has witnessed an exponential increase in the applications of graphene and graphene-based materials in a wide range of fields. For what concerns neuroscience, the interest raised by these materials is two-fold. On…
Three-dimensional interconnected nanowire networks have recently attracted notable attention for the fabrication of new devices for energy harvesting/storage, sensing, catalysis, magnetic and spintronic applications and for the design of…
Magnetic nanoparticles (MNPs) are the foundation of several new strategies for neural repair and neurological therapies. The fact that a remote force can act on MNPs at the cytoplasmic space constitutes the essence of many new…
Extrusion-based 3D printing is a widely utilized tool in tissue engineering, offering precise 3D control of bioinks to construct organ-sized biomaterial objects with hierarchically organized cellularized scaffolds. The internal organization…
Unlike other tissue types, like epithelial tissue, which consist of cells with a much more homogeneous structure and function, the nervous tissue spans in a complex multilayer environment whose topographical features display a large…
Three-dimensional (3D) nanomagnetism is a rapidly developing field within magnetic materials research, where exploiting the third dimension unlocks opportunities for innovative applications in areas such as sensing, data storage, and…
In soft matter science, it is often the goal to design new materials with targeted properties. These materials can be used in many applications, each requiring specific features to be optimized for maximum fitness. The use of self-assembly…
We propose a neural network-based computational framework for the simultaneous optimization of structural topology, curved layers, and path orientations to achieve strong anisotropic strength in fiber-reinforced thermoplastic composites…