相关论文: How important is the seizure onset zone for seizur…
There is increasing evidence for specific cortical and subcortical large-scale human epileptic networks to be involved in the generation, spread, and termination of not only primary generalized but also focal onset seizures. The complex…
The electrical stimulation to the seizure onset zone (SOZ) serves as an efficient approach to seizure suppression. Recently, seizure dynamics have gained widespread attendance in its network propagation mechanisms. Compared with the direct…
The brain is a high-dimensional directional network system consisting of many regions as network nodes that influence each other. The directional influence from one region to another is referred to as directional connectivity. Epilepsy is a…
Drug-resistant epilepsy is traditionally characterized by pathologic cortical tissue comprised of seizure-initiating `foci'. These `foci' are thought to be embedded within an epileptic network whose functional architecture dynamically…
During clinical treatment for epilepsy, the area of the brain thought to be responsible for pathological activity is identified. This identification is typically performed through visual assessment of EEG recordings; however, this is time…
Information transmission in the human brain is a fundamentally dynamic network process. In partial epilepsy, this process is perturbed and highly synchronous seizures originate in a local network, the so-called epileptogenic zone (EZ),…
Epileptic seizures are characterized by abnormal and excessive neural activity, where cortical network dynamics seem to become unstable. However, most of the time, during seizure-free periods, cortex of epilepsy patients shows perfectly…
An ability to map seizure-generating brain tissue, i.e., the seizure onset zone (SOZ), without recording actual seizures could reduce the duration of invasive EEG monitoring for patients with drug-resistant epilepsy. A widely-adopted…
Epilepsy is a neurological disorder identified by sudden and recurrent seizures, which are believed to be accompanied by distinct changes in brain dynamics. Exploring the dynamic changes of brain network states during seizures can pave the…
In many realistic networks, the edges representing the interactions between the nodes are time-varying. There is growing evidence that the complex network that models the dynamics of the human brain has time-varying interconnections, i.e.,…
Epileptic seizures are considered as abnormally hypersynchronous neuronal activities of the brain. Do hypersynchronous neuronal activities in a brain region lead to seizure or the hypersynchronous activities take place due to the…
We assess electrical brain dynamics before, during, and after one-hundred human epileptic seizures with different anatomical onset locations by statistical and spectral properties of functionally defined networks. We observe a concave-like…
In this chapter we review phenomenological models of seizure like activity. We discuss dynamical mechanisms for seizure onset and offset, preictal spikes, spike and wave complexes and status epilepticus, highlighting the role played by the…
Epileptic seizures are one of the most well-known dysfunctions of the nervous system. During a seizure, a highly synchronized behavior of neural activity is observed that can cause symptoms ranging from mild sensual malfunctions to the…
Understanding brain dynamics in epilepsy is critical for establishing rigorous control objectives that enable new therapeutic methods to mitigate seizure occurrence. In multichannel electrocorticography (ECoG) recordings acquired in 21…
Epilepsy is the fourth most common neurological disorder, affecting about 1% of the population at all ages. As many as 60% of people with epilepsy experience focal seizures which originate in a certain brain area and are limited to part of…
Recent studies have shown that seizures can spread and terminate across brain areas via a rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset area is usually in-variant across seizures in a same…
Epileptic seizures are characterised by abnormal brain dynamics at multiple scales, engaging single neurons, neuronal ensembles and coarse brain regions. Key to understanding the cause of such emergent population dynamics, is capturing the…
Epilepsy is one of the most common neurological disorders, often requiring surgical intervention when medication fails to control seizures. For effective surgical outcomes, precise localisation of the epileptogenic focus - often…
Critical dynamics are assumed to be an attractive mode for normal brain functioning as information processing and computational capabilities are found to be optimized there. Recent experimental observations of neuronal activity patterns…