相关论文: Statistical model of evolution of brain parcellati…
Analyzing the brain in terms of organizational structures at intermediate scales provides an approach to negotiate the complexity arising from interactions between its large number of components. Focusing on a wiring diagram that spans the…
One of the primary objectives of human brain mapping is the division of the cortical surface into functionally distinct regions, i.e. parcellation. While it is generally agreed that at macro-scale different regions of the cortex have…
The surface morphology of the developing mammalian brain is crucial for understanding brain function and dysfunction. Computational modeling offers valuable insights into the underlying mechanisms for early brain folding. Recent findings…
In this thesis, we present robust and fully-automated methods for the subdivision of the entire human cerebral cortex based on connectivity information. Our contributions are four-fold: First, we propose a clustering approach to delineate a…
Current theories hold that brain function is highly related to long-range physical connections through axonal bundles, namely extrinsic connectiv-ity. However, obtaining a groupwise cortical parcellation based on extrinsic connectivity…
The cerebral cortex displays a bewildering diversity of shapes and sizes across and within species. Despite this diversity, we present a universal multi-scale description of primate cortices. We show that all cortical shapes can be…
Structure entails function and thus a structural description of the brain will help to understand its function and may provide insights into many properties of brain systems, from their robustness and recovery from damage, to their dynamics…
Neural networks show a progressive increase in complexity during the time course of evolution. From diffuse nerve nets in Cnidaria to modular, hierarchical systems in macaque and humans, there is a gradual shift from simple processes…
Background: We have previously demonstrated that cortical folding across mammalian species follows a universal scaling law that can be derived from a simple theoretical model. The same scaling law has also been shown to hold across brains…
Recent cellular-level volumetric brain reconstructions have revealed high levels of anatomic complexity. Determining which structural aspects of the brain to focus on, especially when comparing with computational models and other organisms,…
We develop a Fokker-Planck theory of tissue growth with three types of cells (symmetrically dividing, asymmetrically dividing and non-dividing) as main agents to study the growth dynamics of human cerebral organoids. Fitting the theory to…
We study neural connectivity in cultures of rat hippocampal neurons. We measure the neurons' response to an electric stimulation for gradual lower connectivity, and characterize the size of the giant cluster in the network. The connectivity…
A formula for an average connectivity between cortical areas in mammals is derived. Based on comparative neuroanatomical data, it is found, surprisingly, that this connectivity is either only weakly dependent or independent of brain size.…
The exterior of the mammalian brain - the cerebral cortex - has a conserved layered structure whose thickness varies little across species. However, selection pressures over evolutionary time scales have led to cortices that have a large…
Microscopic analysis of histological sections is considered the "gold standard" to verify structural parcellations in the human brain. Its high resolution allows the study of laminar and columnar patterns of cell distributions, which build…
Cytoarchitectonic parcellations of the human brain serve as anatomical references in multimodal atlas frameworks. They are based on analysis of cell-body stained histological sections and the identification of borders between brain areas.…
Brain parcellations play a ubiquitous role in the analysis of magnetic resonance imaging (MRI) datasets. Over 100 years of research has been conducted in pursuit of an ideal brain parcellation. Different methods have been developed and…
The cerebrum of mammals spans a vast range of sizes and yet has a very regular structure. The amount of folding of the cortical surface and the proportion of white matter gradually increase with size, but the underlying mechanisms remain…
Our understanding of the structure of the brain and its relationships with human traits is largely determined by how we represent the structural connectome. Standard practice divides the brain into regions of interest (ROIs) and represents…
The organization and connectivity of the arcuate fasciculus (AF) in nonhuman primates remain contentious, especially concerning how its anatomy diverges from that of humans. Here, we combined cross-scale single-neuron tracing - using…