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The tracing of neural pathways through large volumes of image data is an incredibly tedious and time-consuming process that significantly encumbers progress in neuroscience. We are exploring deep learning's potential to automate…

计算机视觉与模式识别 · 计算机科学 2018-09-05 Ishtar Nyawira , Kristi Bushman , Iris Qian , Annie Zhang

Accurate segmentation of neural structures in Electron Microscopy (EM) images is paramount for neuroscience. However, this task is challenged by intricate morphologies, low signal-to-noise ratios, and scarce annotations, limiting the…

计算机视觉与模式识别 · 计算机科学 2025-11-18 Zhenghua Li , Hang Chen , Zihao Sun , Kai Li , Xiaolin Hu

The prospect of neural reconstruction from Electron Microscopy (EM) images has been elucidated by the automatic segmentation algorithms. Although segmentation algorithms eliminate the necessity of tracing the neurons by hand, significant…

计算机视觉与模式识别 · 计算机科学 2015-09-29 Toufiq Parag

In the field of connectomics, neuroscientists seek to identify cortical connectivity comprehensively. Neuronal boundary detection from the Electron Microscopy (EM) images is often done to assist the automatic reconstruction of neuronal…

计算机视觉与模式识别 · 计算机科学 2017-08-01 Wei Shen , Bin Wang , Yuan Jiang , Yan Wang , Alan Yuille

We present SAM4EM, a novel approach for 3D segmentation of complex neural structures in electron microscopy (EM) data by leveraging the Segment Anything Model (SAM) alongside advanced fine-tuning strategies. Our contributions include the…

Brain image analysis has advanced substantially in recent years with the proliferation of neuroimaging datasets acquired at different resolutions. While research on brain image super-resolution has undergone a rapid development in the…

图像与视频处理 · 电气工程与系统科学 2021-05-04 Megi Isallari , Islem Rekik

Reconstructing multiple molecularly defined neurons from individual brains and across multiple brain regions can reveal organizational principles of the nervous system. However, high resolution imaging of the whole brain is a technically…

计算机视觉与模式识别 · 计算机科学 2019-03-19 James Gornet , Kannan Umadevi Venkataraju , Arun Narasimhan , Nicholas Turner , Kisuk Lee , H. Sebastian Seung , Pavel Osten , Uygar Sümbül

The automatic segmentation of perinatal brain structures in magnetic resonance imaging (MRI) is of utmost importance for the study of brain growth and related complications. While different methods exist for adult and pediatric MRI data,…

Biological neural networks define the brain function and intelligence of humans and other mammals, and form ultra-large, spatial, structured graphs. Their neuronal organization is closely interconnected with the spatial organization of the…

Traditional neuroimage analysis pipelines involve computationally intensive, time-consuming optimization steps, and thus, do not scale well to large cohort studies with thousands or tens of thousands of individuals. In this work we propose…

图像与视频处理 · 电气工程与系统科学 2020-06-11 Leonie Henschel , Sailesh Conjeti , Santiago Estrada , Kersten Diers , Bruce Fischl , Martin Reuter

The current neuron reconstruction pipeline for electron microscopy (EM) data usually includes automatic image segmentation followed by extensive human expert proofreading. In this work, we aim to reduce human workload by predicting…

计算机视觉与模式识别 · 计算机科学 2024-01-09 Qihua Chen , Xuejin Chen , Chenxuan Wang , Yixiong Liu , Zhiwei Xiong , Feng Wu

Connectomics is an emerging field in neuroscience that aims to reconstruct the 3-dimensional morphology of neurons from electron microscopy (EM) images. Recent studies have successfully demonstrated the use of convolutional neural networks…

计算机视觉与模式识别 · 计算机科学 2017-02-27 Shibani Santurkar , David Budden , Alexander Matveev , Heather Berlin , Hayk Saribekyan , Yaron Meirovitch , Nir Shavit

Graphs are a representation of structured data that captures the relationships between sets of objects. With the ubiquity of available network data, there is increasing industrial and academic need to quickly analyze graphs with billions of…

机器学习 · 计算机科学 2023-07-28 Brandon Mayer , Anton Tsitsulin , Hendrik Fichtenberger , Jonathan Halcrow , Bryan Perozzi

Brain imaging data such as EEG or MEG are high-dimensional spatiotemporal data often degraded by complex, non-Gaussian noise. For reliable analysis of brain imaging data, it is important to extract discriminative, low-dimensional intrinsic…

计算机视觉与模式识别 · 计算机科学 2017-05-16 Yiluan Guo , Hossein Nejati , Ngai-Man Cheung

One of the critical steps in improving accurate single neuron reconstruction from three-dimensional (3D) optical microscope images is the neuronal structure segmentation. However, they are always hard to segment due to the lack in quality.…

图像与视频处理 · 电气工程与系统科学 2021-01-25 Heng Wang , Yang Song , Chaoyi Zhang , Jianhui Yu , Siqi Liu , Hanchuan Peng , Weidong Cai

Recent advances in 3D imaging technologies provide novel insights to researchers and reveal finer and more detail of examined specimen, especially in the biomedical domain, but also impose huge challenges regarding scalability for automated…

计算机视觉与模式识别 · 计算机科学 2021-06-30 Dominik Drees , Aaron Scherzinger , René Hägerling , Friedemann Kiefer , Xiaoyi Jiang

Graphs are quickly emerging as a leading abstraction for the representation of data. One important application domain originates from an emerging discipline called "connectomics". Connectomics studies the brain as a graph; vertices…

This work describes a novel methodology for automatic contour extraction from 2D images of 3D neurons (e.g. camera lucida images and other types of 2D microscopy). Most contour-based shape analysis methods can not be used to characterize…

计算机视觉与模式识别 · 计算机科学 2008-10-24 J. J. G. Leandro , R. M. Cesar , L. da F. Costa

Structural equation modeling (SEM) is a popular tool in the social and behavioural sciences, where it is being applied to ever more complex data types. The high-dimensional data produced by modern sensors, brain images, or (epi)genetic…

统计方法学 · 统计学 2019-10-11 Erik-Jan van Kesteren , Daniel L. Oberski

The construction of large-scale, high-quality datasets is a fundamental prerequisite for developing robust and generalizable foundation models in motor imagery (MI)-based brain-computer interfaces (BCIs). However, EEG signals collected from…

计算工程、金融与科学 · 计算机科学 2025-06-16 Dingkun Liu , Zhu Chen , Dongrui Wu