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Diffusion coefficient measurements are important for many biological and material investigations, such as particle dynamics, kinetics, and size determinations. Amongst current measurement methods, single particle tracking (SPT) offers the…

生物大分子 · 定量生物学 2011-07-12 Shannon Kian Zareh , Michael C. DeSantis , Jonathan Kessler , Je-Luen Li , Y. M. Wang

Biological functions stem from coordinated interactions among proteins, nucleic acids and small molecules. Mass spectrometry technologies for reliable, high throughput single-cell proteomics will add a new modality to genomics and enable…

基因组学 · 定量生物学 2023-11-07 Andrew Leduc , Hannah Harens , Nikolai Slavov

Self-similar solutions of the coherent diffusion equation are derived and measured. The set of real similarity solutions is generalized by the introduction of a nonuniform phase surface, based on the elegant Gaussian modes of optical…

量子物理 · 物理学 2015-05-19 O. Firstenberg , P. London , D. Yankelev , R. Pugatch , M. Shuker , N. Davidson

In recent years single molecule force spectroscopy has opened a new avenue to provide profiles of the complex energy landscape of biomolecules. In this field, quantitative analyses of the data employing sound theoretical models, have played…

生物大分子 · 定量生物学 2015-01-15 Changbong Hyeon , Michael Hinczewski , D. Thirumalai

The photon statistics of Spontaneous Parametric Down Conversion (SPDC) exhibit dependencies on wavelength, pump power, and coincidence time. Notably, the average photon numbers were found to asymmetrically increase with increasing pump…

量子物理 · 物理学 2026-05-01 Jeffrey Carvalho , Chiran Wijesundara , Tim Thomay

Mapping conformational heterogeneity of macromolecules presents a formidable challenge to X-ray crystallography and cryo-electron microscopy, which often presume its absence. This has severely limited our knowledge of the conformations…

生物物理 · 物理学 2015-05-14 P. Schwander , R. Fung , G. N. Phillips , A. Ourmazd

We propose a general methodology for efficient statistical reconstruction of a quantum state through collection and analysis of photon counting statistics. Our approach includes both strict quantitative criteria for adequacy and…

量子物理 · 物理学 2013-11-07 Yu. I. Bogdanov , S. P. Kulik

Conformational dynamics of biomolecules are of fundamental importance for their function. Single-molecule F\"orster Resonance Energy Transfer (smFRET) is a powerful approach to inform on the structure and the dynamics of labeled molecules.…

We demonstrate with an experiment how molecules are a natural test-bed for probing fundamental quantum thermodynamics. Single-molecule spectroscopy has undergone transformative change in the past decade with the advent of techniques…

量子物理 · 物理学 2017-10-25 Cormac Browne , Tristan Farrow , Oscar C. O. Dahlsten , Vlatko Vedral

This work outlines an exact combinatorial approach to finite coagulating systems through recursive equations and use of generating function method. In the classic approach the mean-field Smoluchowski coagulation is used. However, the…

统计力学 · 物理学 2021-04-16 Michał Łepek , Paweł Kukliński , Agata Fronczak , Piotr Fronczak

Single-molecule localization microscopy allows practitioners to locate and track labeled molecules in biological systems. When extracting diffusion coefficients from the resulting trajectories, it is common practice to perform a linear fit…

生物物理 · 物理学 2024-06-19 Jakob Tómas Bullerjahn , Gerhard Hummer

A light-driven molecular motor system is investigated using a multi-state Brownian ratchet model described by a single effective coordinate with multiple electronic states in a dissipative environment. The rotational motion of the motor…

化学物理 · 物理学 2019-03-22 Tatsushi Ikeda , Arend G. Dijkstra , Yoshitaka Tanimura

Tip-enhanced photoluminescence (TEPL) measurements are performed with sub-nanometer spatial resolution on individual molecules decoupled from a metallic substrate by a thin NaCl layer. TEPL spectra reveal progressive fluorescence quenching…

介观与纳米尺度物理 · 物理学 2024-03-18 Katharina Kaiser , Michelangelo Romeo , Fabrice Scheurer , Guillaume Schull , Anna Rosławska

The time dynamics of spin-injected, electrically contacted quantum dots were investigated with a focus on the time evolution of photon statistics. Photon statistics can provide insights into whether the device functions as an effective…

量子物理 · 物理学 2025-01-30 Chiran Wijesundara , Jeffrey Carvalho , Yuan Lu , Tim Thomay

A unified expression for topological invariants has been proposed recently to describe the topological order in Dirac models belonging to any dimension and symmetry class. We uncover a correspondence between the curvature function that…

介观与纳米尺度物理 · 物理学 2021-11-19 Gero von Gersdorff , Wei Chen

Subnatural-linewidth single-photon source is a potential candidate for exploring the time degree of freedom in photonic quantum information science. This type of single-photon source has been demonstrated to be generated and reshaped in…

量子物理 · 物理学 2018-11-14 Ce Yang , Zhenjie Gu , Peng Chen , Zhongzhong Qin , J. F. Chen , Weiping Zhang

We have analyzed with pedagogical purposes the relation of the total densities of states (TDOS/PDOS/OPDOS) and molecular orbital diagrams (MOD) for single and isolated molecules of Water and Nitrogen. We use a calculation level HF/6-311G,…

化学物理 · 物理学 2022-03-07 P. Contreras , L. Seijas , Dianela Osorio

To be able to resolve molecular-clusters it is crucial to access vital informations (such as, molecule density and cluster-size) that are key to understand disease progression and the underlying mechanism. Traditional single-molecule…

定量方法 · 定量生物学 2021-01-27 Partha Pratim Mondal

Single and multi-photon ionization of aligned molecular ensembles is examined, with a particular focus on the link between the molecular axis distribution and observable in various angle-integrated and angle-resolved measurements. To…

化学物理 · 物理学 2015-03-04 Paul Hockett

Single-particle tracking allows to infer the motion of single molecules in living cells. When we observe a long trajectory (more than 100 points), it is possible that the particle switches mode of motion over time. Then, fitting a single…

统计方法学 · 统计学 2018-04-16 Vincent Briane , Charles Kervrann , Myriam Vimond
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