相关论文: Managing HIV/AIDS in Malawi
Combination Antiretroviral Therapy (cART) succeeds to control viral replication in most HIV infected patients. This is normally followed by a reconstitution of the CD4$^+$ T cells pool; however, this does not happen for a substantial…
Social context plays an important role in perpetuating or reducing HIV risk behaviors. This study analyzed the network and individual attributes that were associated with the likelihood that people who inject drugs (PWID) will engage in HIV…
Governments spend billions of dollars subsidizing the adoption of different goods. However, it is difficult to gauge whether those goods are resold, or are valued by their ultimate recipients. This project studies a program to subsidize the…
Missing data is unavoidable in longitudinal clinical trials, and outcomes are not always normally distributed. In the presence of outliers or heavy-tailed distributions, the conventional multiple imputation with the mixed model with…
HIV-1 infection currently cannot be cured because the virus persists as integrated proviral DNA in long-lived cells despite years of suppressive antiretroviral therapy (ART). To characterize establishment, turnover, and evolution of viral…
Our chances to halt epidemic outbreaks rely on how accurately we represent the population structure underlying the disease spread. When analyzing global epidemics this force us to consider metapopulation models taking into account intra-…
In this letter, we mainly consider an MSM (men have sex with men) network to analysis how monogamy behavior can influence the transmission of HIV. By calculating and analyzing the basic reproductive number of that network, we find the…
HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts. The contribution of this…
As computational capacity increases, it becomes possible to model health systems in greater detail. Multi-disease health system models (HSMs) represent a new development, building on individual level epidemiological models of multiple…
This paper presents a mathematical model to investigate co-infection with HIV/AIDS and zika virus (ZIKV) in Colombia and Brazil, where the first cases were reported in 2015-2016. The model considers the sexual transmission dynamics of both…
Healthcare in Africa is a complex issue influenced by many factors including poverty, lack of infrastructure, and inadequate funding. However, Artificial intelligence (AI) applied to healthcare, has the potential to transform healthcare in…
We develop a simple 3-dimensional iterative map model to forecast the global spread of the coronavirus disease. Our model contains at most two fitting parameters, which we determine from the data supplied by the world health organisation…
The World Health Organization (WHO) guidelines for monitoring the effectiveness of HIV treatment in resource-limited settings (RLS) are mostly based on clinical and immunological markers (e.g., CD4 cell counts). Recent research indicates…
Malaria, childhood acute respiratory infection, and child undernutrition together account for over two million deaths annually in children under five, with the burden concentrated in low and middle-income countries where climate variability…
This document provides the statistical analytic plan (SAP) for evaluating health outcomes in the SEARCH-Youth study, a cluster randomized trial designed to evaluate the effect of a combination intervention on HIV viral suppression among…
We study long-run selection and treatment effects of a health insurance subsidy in Ghana, where mandates are not enforceable. We randomly provide different levels of subsidy (1/3, 2/3, and full), with follow-up surveys seven months and…
HIV transmission within serodiscordant couples remains a significant public health challenge, particularly in sub-Saharan Africa. Estimating the rate of such infection, alongside the rates of introduction of infection from outside the…
The increasing prevalence of chronic diseases poses a significant challenge to global efforts to alleviate poverty, promote health equity, and control healthcare costs. This study adopts a structural approach to explore how patients manage…
We consider an epidemiological SIR model and a positive threshold $M$. Using a parametric expression for the solution curve of the SIR model and the Lambert W function, we establish necessary and sufficient conditions on the basic…
Adolescent girls and young women (AGYW) in sub-Saharan Africa face unique barriers to contraceptive access and lack AGYW-centered contraceptive decision-support resources. To empower AGYW to make informed choices and improve reproductive…