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We study a system of dynamical units, each of which shows excitable or oscillatory behavior, depending on the choice of parameters. When we couple these units with repressive bonds, we can control the duration of collective oscillations for…

分子网络 · 定量生物学 2014-02-06 Darka Labavic , Hildegard Meyer-Ortmanns

The theory of mixed-feedback systems provides an effective framework for the design of robust and tunable oscillations in nonlinear systems characterized by interleaved fast positive and slow negative feedback loops. The goal of this paper…

动力系统 · 数学 2024-12-11 Omar Juarez-Alvarez , Alessio Franci

We study a system of two-mode stochastic oscillators coupled through their collective output. As a function of a relevant parameter four qualitatively distinct regimes of collective behavior are observed. In an extended region of the…

统计力学 · 物理学 2009-11-07 A. Nikitin , Z. Neda , T. Vicsek

Complex network dynamics have been analyzed with models of systems of coupled switches or systems of coupled oscillators. However, many complex systems are composed of components with diverse dynamics whose interactions drive the system's…

定量方法 · 定量生物学 2012-01-09 Matthew R. Francis , Elana J. Fertig

We analyze a class of network motifs in which a short, two-node positive feed- back motif is inserted in a three-node negative feedback loop. We demonstrate that such networks can undergo a bifurcation to a state where a stable fixed point…

分子网络 · 定量生物学 2012-09-10 Weihan Li , Sandeep Krishna , Simone Pigolotti , Namiko Mitarai , Mogens H. Jensen

Genetically encoded regulatory circuits control biological function. A major focus of systems biology is to understand these circuits by establishing the relationship between specific structures and functions. Of special interest are…

分子网络 · 定量生物学 2017-08-17 Ruben Perez-Carrasco , Chris P. Barnes , Yolanda Schaerli , Mark Isalan , James Briscoe , Karen M. Page

We study a system of coupled phase oscillators near a saddle-node on an invariant circle bifurcation and driven by random intrinsic frequencies. Under the variation of control parameters, the system undergoes a phase transition changing the…

适应与自组织系统 · 物理学 2022-08-18 Georgi S. Medvedev , Matthew S. Mizuhara , Andrew Phillips

We discuss the transition paths in a coupled bistable system consisting of interacting multiple identical bistable motifs. We propose a simple model of coupled bistable gene circuits as an example, and show that its transition paths are…

分子网络 · 定量生物学 2016-11-03 Chengzhe Tian , Namiko Mitarai

Many natural systems including the brain comprise coupled non-uniformly stimulated elements. In this paper we show that heterogeneously driven networks of excitatory-inhibitory units exhibit striking collective phenomena, including…

适应与自组织系统 · 物理学 2016-03-23 Varsha Sreenivasan , Shakti N. Menon , Sitabhra Sinha

Mixed positive and negative feedback loops are often found in biological systems which support oscillations. In this work we consider a prototype of such systems, which has been recently found at the core of many genetic circuits showing…

统计力学 · 物理学 2015-06-03 Ashok Garai , Bartlomiej Waclaw , Hannes Nagel , Hildegard Meyer-Ortmanns

Pulse-coupled systems such as spiking neural networks exhibit nontrivial invariant sets in the form of attracting yet unstable saddle periodic orbits where units are synchronized into groups. Heteroclinic connections between such orbits may…

适应与自组织系统 · 物理学 2020-11-03 Fabio Schittler Neves , Marc Timme

We show that subsets of interacting oscillators may synchronize in different ways within a single network. This diversity of synchronization patterns is promoted by increasing the heterogeneous distribution of coupling weights and/or…

斑图形成与孤子 · 物理学 2017-04-05 Daniel Malagarriga , Alessandro E. P. Villa , Jordi García-Ojalvo , Antonio J. Pons

The onset of synchronization in networks of networks is investigated. Specifically, we consider networks of interacting phase oscillators in which the set of oscillators is composed of several distinct populations. The oscillators in a…

动力系统 · 数学 2009-11-13 Ernest Barreto , Brian Hunt , Edward Ott , Paul So

The emergence of synchronization in a network of coupled oscillators is a pervasive topic in various scientific disciplines ranging from biology, physics, and chemistry to social networks and engineering applications. A coupled oscillator…

最优化与控制 · 数学 2012-09-07 Florian Dörfler , Francesco Bullo

In networked systems, the interplay between the dynamics of individual subsystems and their network interactions has been found to generate multistability in various contexts. Despite its ubiquity, the specific mechanisms and ingredients…

动力系统 · 数学 2024-11-22 Kalel L. Rossi , Everton S. Medeiros , Peter Ashwin , Ulrike Feudel

Simple nonlinear dynamical systems with multiple stable stationary states are often taken as models for switchlike biological systems. This paper considers the interaction of multiple such simple multistable systems when they are embedded…

定量方法 · 定量生物学 2008-04-10 Dennis Cates Wylie

Large ensembles of globally coupled chaotic neural networks undergo a transition to complete synchronization for high coupling intensities. The onset of this fully coherent behavior is preceded by a regime where clusters of networks with…

adap-org · 物理学 2008-02-03 D. H. Zanette , A. S. Mikhailov

In general, the behavior of large and complex aggregates of elementary components can not be understood nor extrapolated from the properties of a few components. The brain is a good example of this type of networked systems where some…

混沌动力学 · 物理学 2012-08-02 Ricardo Lopez-Ruiz , Daniele Fournier-Prunaret

Controlling spatial patterns in synthetic biological systems remains challenging due to poor parameter robustness and limited experimental tunability. We introduce two complementary mechanisms-the pattern switch and the pattern dial-to…

生物物理 · 物理学 2025-12-02 Antonio Matas-Gil , Robert G. Endres

According to the chemical reaction network theory, the topology of a certain class of chemical reaction networks, regardless of the kinetic details, sets a limit on the dynamical properties that a particular network can potentially admit;…

分子网络 · 定量生物学 2014-08-21 Jaewook Joo , Sanjeev Chauhan
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