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We introduce a probabilistic framework for two-sample comparison based on a nonparametric process taking the form of a Markov model that transitions between a "divide" and a "merge" state on a multi-resolution partition tree of the sample…

统计方法学 · 统计学 2014-05-30 Jacopo Soriano , Li Ma

Completely random measures (CRMs) provide a broad class of priors, arguably, the most popular, for Bayesian nonparametric (BNP) analysis of trait allocations. As a peculiar property, CRM priors lead to predictive distributions that share…

统计方法学 · 统计学 2023-04-03 Mario Beraha , Stefano Favaro

There is a growing interest in the estimation of the number of unseen features, mostly driven by biological applications. A recent work brought out a peculiar property of the popular completely random measures (CRMs) as prior models in…

统计方法学 · 统计学 2022-02-22 Federico Camerlenghi , Stefano Favaro , Lorenzo Masoero , Tamara Broderick

CRISPR technology has enabled large-scale cell lineage tracing for complex multicellular organisms by mutating synthetic genomic barcodes during organismal development. However, these sophisticated biological tools currently use ad-hoc and…

定量方法 · 定量生物学 2019-04-02 Jean Feng , William S DeWitt , Aaron McKenna , Noah Simon , Amy Willis , Frederick A Matsen

The human body is able to generate a diverse set of high affinity antibodies, the soluble form of B cell receptors (BCRs), that bind to and neutralize invading pathogens. The natural development of BCRs must be understood in order to design…

统计方法学 · 统计学 2020-09-09 Amrit Dhar , Duncan K. Ralph , Vladimir N. Minin , Frederick A. Matsen

Examination of T-cell receptor (TCR) clonality has become a way of understanding immunologic response to cancer and its interventions in recent years. An aspect of these analyses is determining which receptors expand or contract…

定量方法 · 定量生物学 2026-01-09 David Swanson , Alexander Sherry , Cara Haymaker , Alexandre Reuben , Chad Tang

Retrosynthesis, the process of deconstructing a target molecule into simpler precursors, is crucial for computer-aided synthesis planning (CASP). Widely adopted tree-search methods often suffer from exponential computational complexity. In…

人工智能 · 计算机科学 2026-01-07 Yu Shee , Anthony M. Smaldone , Anton Morgunov , Gregory W. Kyro , Victor S. Batista

Summaries of craters on terrestrial bodies, such as the number and size distribution, are essential for understanding the history of the Solar System. Identifying craters, however, has not been automated and thus relies on expert…

统计方法学 · 统计学 2026-05-21 Nathan Weed , Emily Castleton , Dave Osthus , Brian Weaver , Richard L. Warr

Bayesian model-based spatial clustering methods are widely used for their flexibility in estimating latent clusters with an unknown number of clusters while accounting for spatial proximity. Many existing methods are designed for clustering…

统计方法学 · 统计学 2025-08-13 Kun Huang , Huiyan Sang

Accurate tumor classification is essential for selecting effective treatments, but current methods have limitations. Standard tumor grading, which categorizes tumors based on cell differentiation, is not recommended as a stand-alone…

计算机视觉与模式识别 · 计算机科学 2025-02-11 Marianne Abémgnigni Njifon , Tobias Weber , Viktor Bezborodov , Tyll Krueger , Dominic Schuhmacher

Phylogenetic trees are leaf-labelled trees used to model the evolution of species. Here we explore the practical impact of kernelization (i.e. data reduction) on the NP-hard problem of computing the TBR distance between two unrooted binary…

数据结构与算法 · 计算机科学 2023-08-21 Rim van Wersch , Steven Kelk , Simone Linz , Georgios Stamoulis

Bayesian Decision Trees (DTs) are generally considered a more advanced and accurate model than a regular Decision Tree (DT) because they can handle complex and uncertain data. Existing work on Bayesian DTs uses Markov Chain Monte Carlo…

机器学习 · 计算机科学 2023-05-31 Efthyvoulos Drousiotis , Alexander M. Phillips , Paul G. Spirakis , Simon Maskell

Tree kernels are fundamental tools that have been leveraged in many applications, particularly those based on machine learning for Natural Language Processing tasks. In this paper, we devise a parallel implementation of the sequential…

计算与语言 · 计算机科学 2023-05-16 Souad Taouti , Hadda Cherroun , Djelloul Ziadi

Decision trees are well-known due to their ease of interpretability. To improve accuracy, we need to grow deep trees or ensembles of trees. These are hard to interpret, offsetting their original benefits. Shapley values have recently become…

机器学习 · 计算机科学 2023-01-26 Peng Yu , Chao Xu , Albert Bifet , Jesse Read

We present a sequential sampling methodology for weakly structural Markov laws, arising naturally in a Bayesian structure learning context for decomposable graphical models. As a key component of our suggested approach, we show that the…

统计理论 · 数学 2019-09-04 Jimmy Olsson , Tetyana Pavlenko , Felix L. Rios

Tumours develop in an evolutionary process, in which the accumulation of mutations produces subpopulations of cells with distinct mutational profiles, called clones. This process leads to the genetic heterogeneity widely observed in tumour…

应用统计 · 统计学 2017-02-07 Francesco Marass , Florent Mouliere , Ke Yuan , Nitzan Rosenfeld , Florian Markowetz

Decision trees are commonly used predictive models due to their flexibility and interpretability. This paper is directed at quantifying the uncertainty of decision tree predictions by employing a Bayesian inference approach. This is…

机器学习 · 计算机科学 2024-03-28 Jodie A. Cochrane , Adrian Wills , Sarah J. Johnson

Cancer is a complex disease characterized by uncontrolled cell growth and proliferation. T cell receptors (TCRs) are essential proteins for the adaptive immune system, and their specific recognition of antigens plays a crucial role in the…

机器学习 · 计算机科学 2023-09-07 Zahra Tayebi , Sarwan Ali , Prakash Chourasia , Taslim Murad , Murray Patterson

Clustering procedures typically estimate which data points are clustered together, a quantity of primary importance in many analyses. Often used as a preliminary step for dimensionality reduction or to facilitate interpretation, finding…

统计方法学 · 统计学 2017-12-06 Ryan Giordano , Runjing Liu , Nelle Varoquaux , Michael I. Jordan , Tamara Broderick

Current popular methods for Magnetic Resonance Fingerprint (MRF) recovery are bottlenecked by the heavy computations of a matched-filtering step due to the growing size and complexity of the fingerprint dictionaries in multi-parametric…

计算机视觉与模式识别 · 计算机科学 2018-10-05 Mohammad Golbabaee , Zhouye Chen , Yves Wiaux , Mike Davies