相关论文: YFitter: Maximum likelihood assignment of Y chromo…

Y haplogroup analyses are an important component of genealogical reconstruction, population genetic analyses, medical genetics and forensics. These fields are increasingly moving towards use of low-coverage, high throughput sequencing.…

This paper introduces a conformal inference method to evaluate uncertainty in classification by generating prediction sets with valid coverage conditional on adaptively chosen features. These features are carefully selected to reflect…

Over the past decades, there has been a surge of interest in studying low-dimensional structures within high-dimensional data. Statistical factor models $-$ i.e., low-rank plus diagonal covariance structures $-$ offer a powerful framework…

In the last decade, due to high resolution cameras and accurate meta-phase analyzes, the accuracy of chromosome classification has improved substantially. However, current Karyotyping systems demand large number of high quality train data…

SweepFinder is a popular program that implements a powerful likelihood-based method for detecting recent positive selection, or selective sweeps. Here, we present SweepFinder2, an extension of SweepFinder with increased sensitivity and…

If you are predicting the label $y$ of a new object with $\hat y$, how confident are you that $y = \hat y$? Conformal prediction methods provide an elegant framework for answering such question by building a $100 (1 - \alpha)\%$ confidence…

High-throughput shotgun sequence data makes it possible in principle to accurately estimate population genetic parameters without confounding by SNP ascertainment bias. One such statistic of interest is the proportion of heterozygous sites…

We present a novel algorithm for generating robust and consistent hypotheses for multiple-structure model fitting. Most of the existing methods utilize random sampling which produce varying results especially when outlier ratio is high. For…

Convolutional image classifiers can achieve high predictive accuracy, but quantifying their uncertainty remains an unresolved challenge, hindering their deployment in consequential settings. Existing uncertainty quantification techniques,…

Many genomic experiments, notably microarray experiments seeking to detect differential gene expression, involve calculating a large number of p-values. This leads to the multiple testing problem: when the number of null hypotheses is…

This paper proposes a new method for finding the highest predictive density set or region, within the heteroscedastic regression framework. This framework enjoys the property that any highest predictive density set is a translation of some…

A novel and efficient neural decoder algorithm is proposed. The proposed decoder is based on the neural Belief Propagation algorithm and the Automorphism Group. By combining neural belief propagation with permutations from the Automorphism…

In the context of a species sampling problem we discuss a non-parametric maximum likelihood estimator for the underlying probability mass function. The estimator is known in the computer science literature as the high profile estimator. We…

Background: Haplotypes, the ordered lists of single nucleotide variations that distinguish chromosomal sequences from their homologous pairs, may reveal an individual's susceptibility to hereditary and complex diseases and affect how our…

In this paper, we propose a new wrapper feature selection approach with partially labeled training examples where unlabeled observations are pseudo-labeled using the predictions of an initial classifier trained on the labeled training set.…

The treatment of short-tandem-repeat (STR) loci on the Y chromosome presents special problems in the forensic analysis of DNA mixtures, chiefly but not exclusively relating to the linkage of Y-STR loci which precludes the use of the…

Consider the binary classification problem of predicting a target variable $Y$ from a discrete feature vector $X = (X_1,...,X_d)$. When the probability distribution $\mathbb{P}(X,Y)$ is known, the optimal classifier, leading to the minimum…

In biomedical imaging, deep learning-based methods are state-of-the-art for every modality (virtual slides, MRI, etc.) In histopathology, these methods can be used to detect certain biomarkers or classify lesions. However, such techniques…

Medical imaging classifiers can achieve high predictive accuracy, but quantifying their uncertainty remains an unresolved challenge, which prevents their deployment in medical clinics. We present an algorithm that can modify any classifier…

In recent years the importance of finding a meaningful pattern from huge datasets has become more challenging. Data miners try to adopt innovative methods to face this problem by applying feature selection methods. In this paper we propose…