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We propose an interpretable 3D Grid-Attention deep neural network that can accurately predict a person's age and whether they have Alzheimer's disease (AD) from a structural brain MRI scan. Building on a 3D convolutional neural network, we…

组织与器官 · 定量生物学 2020-11-19 Pradeep Lam , Alyssa H. Zhu , Iyad Ba Gari , Neda Jahanshad , Paul M. Thompson

Age is an essential factor in modern diagnostic procedures. However, assessment of the true biological age (BA) remains a daunting task due to the lack of reference ground-truth labels. Current BA estimation approaches are either restricted…

计算机视觉与模式识别 · 计算机科学 2021-05-18 Karim Armanious , Sherif Abdulatif , Wenbin Shi , Tobias Hepp , Sergios Gatidis , Bin Yang

We implement the dynamical Ising model on the large scale architecture of white matter connections of healthy subjects in the age range 4-85 years, and analyze the dynamics in terms of the synergy, a quantity measuring the extent to which…

神经元与认知 · 定量生物学 2020-05-15 Davide Nuzzi , Mario Pellicoro , Leonardo Angelini , Daniele Marinazzo , Sebastiano Stramaglia

How will my face look when I get older? Or, for a more challenging question: How will my brain look when I get older? To answer this question one must devise (and learn from data) a multivariate auto-regressive function which given an image…

图像与视频处理 · 电气工程与系统科学 2021-10-01 Tian Xia , Agisilaos Chartsias , Chengjia Wang , Sotirios A. Tsaftaris

Brain age estimation from Magnetic Resonance Images (MRI) derives the difference between a subject's biological brain age and their chronological age. This is a potential biomarker for neurodegeneration, e.g. as part of Alzheimer's disease.…

计算机视觉与模式识别 · 计算机科学 2020-10-02 Kyriaki-Margarita Bintsi , Vasileios Baltatzis , Arinbjörn Kolbeinsson , Alexander Hammers , Daniel Rueckert

Brain network analysis plays a crucial role in diagnosing and monitoring neurodegenerative disorders such as Alzheimer's disease (AD). Existing approaches for constructing structural brain networks from diffusion tensor imaging (DTI) often…

神经元与认知 · 定量生物学 2025-05-30 Xuhang Chen , Michael Kwok-Po Ng , Kim-Fung Tsang , Chi-Man Pun , Shuqiang Wang

Diffusion MRI (dMRI) tractography enables in vivo mapping of brain structural connections, but traditional connectome generation is time-consuming and requires gray matter parcellation, posing challenges for large-scale studies. We…

图像与视频处理 · 电气工程与系统科学 2025-06-12 Marcus J. Vroemen , Yuqian Chen , Yui Lo , Tengfei Xue , Weidong Cai , Fan Zhang , Josien P. W. Pluim , Lauren J. O'Donnell

Individuals age differently depending on a multitude of different factors such as lifestyle, medical history and genetics. Often, the global chronological age is not indicative of the true ageing process. An organ-based age estimation would…

图像与视频处理 · 电气工程与系统科学 2020-12-29 Karim Armanious , Sherif Abdulatif , Anish Rao Bhaktharaguttu , Thomas Küstner , Tobias Hepp , Sergios Gatidis , Bin Yang

Age is an important variable to describe the expected brain's anatomy status across the normal aging trajectory. The deviation from that normative aging trajectory may provide some insights into neurological diseases. In neuroimaging,…

计算机视觉与模式识别 · 计算机科学 2023-04-14 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé

Diffusion tensor imaging (DTI) has been used to study the effects of neurodegenerative diseases on neural pathways, which may lead to more reliable and early diagnosis of these diseases as well as a better understanding of how they affect…

计算机视觉与模式识别 · 计算机科学 2021-12-15 Chaoqing Xu , Tyson Neuroth , Takanori Fujiwara , Ronghua Liang , Kwan-Liu Ma

In this study, we propose the use of persistent homology -- specifically Betti curves for brain age prediction and for distinguishing between healthy and pathological aging. The proposed framework is applied to 100 structural MRI scans from…

神经元与认知 · 定量生物学 2025-11-11 Debanjali Bhattacharya , Neelam Sinha

Brain age estimation based on magnetic resonance imaging (MRI) is an active research area in early diagnosis of some neurodegenerative diseases (e.g. Alzheimer, Parkinson, Huntington, etc.) for elderly people or brain underdevelopment for…

图像与视频处理 · 电气工程与系统科学 2021-08-04 Ruizhe Li , Matteo Bastiani , Dorothee Auer , Christian Wagner , Xin Chen

Most deep learning models for temporal regression directly output the estimation based on single input images, ignoring the relationships between different images. In this paper, we propose deep relation learning for regression, aiming to…

计算机视觉与模式识别 · 计算机科学 2022-04-15 Sheng He , Yanfang Feng , P. Ellen Grant , Yangming Ou

Magnetic resonance diffusion tensor imaging (DTI) is a critical tool for neural disease diagnosis. However, long scan time greatly hinders the widespread clinical use of DTI. To accelerate image acquisition, a feature-enhanced joint…

图像与视频处理 · 电气工程与系统科学 2024-05-28 Lang Zhang , Jinling He , Dong Liang , Hairong Zheng , Yanjie Zhu

Diffusion tensor imaging (DTI) provides crucial insights into the microstructure of the human brain, but it can be time-consuming to acquire compared to more readily available T1-weighted (T1w) magnetic resonance imaging (MRI). To address…

计算机视觉与模式识别 · 计算机科学 2025-04-22 Shaorong Zhang , Tamoghna Chattopadhyay , Sophia I. Thomopoulos , Jose-Luis Ambite , Paul M. Thompson , Greg Ver Steeg

The human spine is a complex structure composed of 33 vertebrae. It holds the body and is important for leading a healthy life. The spine is vulnerable to age-related degenerations that can be identified through magnetic resonance imaging…

Determining if the brain is developing normally is a key component of pediatric neuroradiology and neurology. Brain magnetic resonance imaging (MRI) of infants demonstrates a specific pattern of development beyond simply myelination. While…

图像与视频处理 · 电气工程与系统科学 2021-12-28 Mahdieh Shabanian , Markus Wenzel , John P. DeVincenzo

Brain age prediction models have succeeded in predicting clinical outcomes in neurodegenerative diseases, but can struggle with tasks involving faster progressing diseases and low quality data. To enhance their performance, we employ a…

Principles of network topology have been widely studied in the human connectome. Of particular interest is the modularity of the human brain, where the connectome is divided into subnetworks and subsequently changes with development, aging…

神经元与认知 · 定量生物学 2019-02-05 Markus D. Schirmer , Ai Wern Chung , P. Ellen Grant , Natalia S. Rost

Human brain networks can be characterized at different temporal or spatial scales given by the age of the subject or the spatial resolution of the neuroimaging method. Integration of data across scales can only be successful if the combined…