相关论文: Homogenization Model for Aberrant Crypt Foci
A bootstrap percolation process on a graph G is an "infection" process which evolves in rounds. Initially, there is a subset of infected nodes and in each subsequent round every uninfected node which has at least r infected neighbours…
We present a mathematical model that describes how tumour heterogeneity evolves in a tissue slice that is oxygenated by a single blood vessel. Phenotype is identified with the stemness level of a cell, $s$, that determines its proliferative…
Accurate tumor segmentation in PET/CT images is crucial for computer-aided cancer diagnosis and treatment. The primary challenge lies in effectively integrating the complementary information from PET and CT images. In clinical settings, the…
For every $\alpha < \frac13$, we construct an explicit divergence-free vector field $\mathbf{b}(t,x)$ which is periodic in space and time and belongs to $C^0_t C^{\alpha}_x \cap C^{\alpha}_t C^0_x$ such that the corresponding scalar…
Colonoscopy is a procedure to detect colorectal polyps which are the primary cause for developing colorectal cancer. However, polyp segmentation is a challenging task due to the diverse shape, size, color, and texture of polyps, shuttle…
Regulation of cell proliferation is a crucial aspect of tissue development and homeostasis and plays a major role in morphogenesis, wound healing, and tumor invasion. A phenomenon of such regulation is contact inhibition, which describes…
The majority of cancer treatments end in failure due to Intra-Tumor Heterogeneity (ITH). ITH in cancer is represented by clonal evolution where different sub-clones compete with each other for resources under conditions of Darwinian natural…
Colorectal cancer (CRC) is one of the most common types of cancer with a high mortality rate. Colonoscopy is the preferred procedure for CRC screening and has proven to be effective in reducing CRC mortality. Thus, a reliable computer-aided…
The mechanisms behind the fragmentation of high-mass dense clumps into compact star-forming cores are fundamental topics in current astrophysical research. The ALMAGAL survey provides the opportunity to study this process at an…
Cancer is a fatal disease caused by a combination of genetic diseases and a variety of biochemical abnormalities. Lung and colon cancer have emerged as two of the leading causes of death and disability in humans. The histopathological…
Cancer patient diagnosis and prognosis is informed by assessment of morphological properties observed in patient tissue. Pathologists normally carry out this assessment, yet advances in computational image analysis provide opportunities for…
We report on a theoretical model for image formation in full-field optical coherence tomography (FFOCT). Because the spatial incoherence of the illumination acts as a virtual confocal pinhole in FFOCT, its imaging performance is equivalent…
While pathology foundation models have transformed cancer image analysis, they often lack integration with molecular data at single-cell resolution, limiting their utility for precision oncology. Here, we present PAST, a pan-cancer…
In order to fulfill cell proliferation and differentiation through cellular hierarchy, stem cells can undergo either asymmetric or symmetric divisions. Recent studies pay special attention to the effect of different modes of stem cell…
Coherent angular rotation of epithelial cells is thought to contribute to many vital physiological processes including tissue morphogenesis and glandular formation. However, factors regulating this motion, and the implications of this…
Cardiac amyloidosis (CA) is a rare cardiomyopathy, with typical abnormalities in clinical measurements from echocardiograms such as reduced global longitudinal strain of the myocardium. An alternative approach for detecting CA is via neural…
The random motion of molecules in living cells has consistently been reported to deviate from standard Brownian motion, a behavior coined as ``anomalous diffusion''. Fluorescence Correlation Spectroscopy (FCS) is a powerful method to…
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and a leading cause of cancer deaths in the United States. Colorectal polyps that grow on the intima of the colon or rectum is an important precursor for CRC. Currently,…
Amorphous graphene or amorphous monolayer carbon (AMC) is a family of carbon films that exhibit a surprising sensitivity of electronic conductance to morphology. We combine deep learning-enhanced simulation techniques with percolation…
Cox proportional hazard model (CPH) is commonly used in clinical research for survival analysis. In quantitative medical imaging (radiomics) studies, CPH plays an important role in feature reduction and modeling. However, the underlying…