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We introduce AMix-1, a powerful protein foundation model built on Bayesian Flow Networks and empowered by a systematic training methodology, encompassing pretraining scaling laws, emergent capability analysis, in-context learning mechanism,…

Compound AI Systems (CAIS) are an emerging paradigm that integrates large language models (LLMs) with external components, including retrievers, agents, tools, and orchestrators, to overcome the limitations of standalone models in tasks…

多智能体系统 · 计算机科学 2026-05-11 Jiayi Chen , Junyi Ye , Guiling Wang

Feature embedding learning and feature interaction modeling are two crucial components of deep models for Click-Through Rate (CTR) prediction. Most existing deep CTR models suffer from the following three problems. First, feature…

信息检索 · 计算机科学 2021-12-14 Chenxu Zhu , Bo Chen , Weinan Zhang , Jincai Lai , Ruiming Tang , Xiuqiang He , Zhenguo Li , Yong Yu

The goal of protein representation learning is to extract knowledge from protein databases that can be applied to various protein-related downstream tasks. Although protein sequence, structure, and function are the three key modalities for…

生物大分子 · 定量生物学 2024-05-14 Eunji Ko , Seul Lee , Minseon Kim , Dongki Kim

Our topic is the use of machine learning to improve software by making choices which do not compromise the correctness of the output, but do affect the time taken to produce such output. We are particularly concerned with computer algebra…

符号计算 · 计算机科学 2020-04-16 Dorian Florescu , Matthew England

Classifying genome sequences based on metadata has been an active area of research in comparative genomics for decades with many important applications across the life sciences. Established methods for classifying genomes can be broadly…

基因组学 · 定量生物学 2025-01-17 Wan He , Tina Eliassi-Rad , Samuel V. Scarpino

Spatial Independent Component Analysis (ICA) is an increasingly used data-driven method to analyze functional Magnetic Resonance Imaging (fMRI) data. To date, it has been used to extract meaningful patterns without prior information.…

计算机视觉与模式识别 · 计算机科学 2009-11-25 Gaël Varoquaux , Sepideh Sadaghiani , Jean Baptiste Poline , Bertrand Thirion

Data pruning, or instance selection, is an important problem in machine learning especially in terms of nearest neighbour classifier. However, in data pruning which speeds up the prediction phase, there is an issue related to the speed and…

机器学习 · 计算机科学 2025-01-22 Marcin Blachnik , Piotr Ciepliński

DNA sequence classification is a fundamental task in computational biology with vast implications for applications such as disease prevention and drug design. Therefore, fast high-quality sequence classifiers are significantly important.…

Kernel methods have been proven to be a powerful tool for the integration and analysis of highthroughput technologies generated data. Kernels offer a nonlinear version of any linear algorithm solely based on dot products. The kernelized…

应用统计 · 统计学 2024-11-27 Mitja Briscik , Marie-Agnès Dillies , Sébastien Déjean

Artificial Intelligence (AI) has the potential to revolutionize diagnosis and segmentation in medical imaging. However, development and clinical implementation face multiple challenges including limited data availability, lack of…

图像与视频处理 · 电气工程与系统科学 2025-01-22 Zelong Liu , Andrew Tieu , Nikhil Patel , Georgios Soultanidis , Louisa Deyer , Ying Wang , Sean Huver , Alexander Zhou , Yunhao Mei , Zahi A. Fayad , Timothy Deyer , Xueyan Mei

We present a new algorithm for Independent Component Analysis (ICA) which has provable performance guarantees. In particular, suppose we are given samples of the form $y = Ax + \eta$ where $A$ is an unknown $n \times n$ matrix and $x$ is a…

机器学习 · 计算机科学 2012-11-13 Sanjeev Arora , Rong Ge , Ankur Moitra , Sushant Sachdeva

Adapting large language models (LLMs) to specific domains often faces a critical bottleneck: the scarcity of high-quality, human-curated data. While large volumes of unchecked data are readily available, indiscriminately using them for…

计算与语言 · 计算机科学 2025-09-09 Jian Wu , Hang Yu , Bingchang Liu , Wenjie Yang , Peng Di , Jianguo Li , Yue Zhang

In recent years Artificial Intelligence has emerged as a fundamental tool in medical applications. Despite this rapid development, deep neural networks remain black boxes that are difficult to explain, and this represents a major limitation…

图像与视频处理 · 电气工程与系统科学 2024-05-22 Tommaso Torda , Andrea Ciardiello , Simona Gargiulo , Greta Grillo , Simone Scardapane , Cecilia Voena , Stefano Giagu

In this paper, a novel pinching-antenna assisted index modulation (PA-IM) scheme is proposed for improving the spectral efficiency without increasing the hardware complexity, where the information bits are conveyed not only by the…

信号处理 · 电气工程与系统科学 2026-02-13 Shuaixin Yang , Yijia Li , Yue Xiao , Yong Liang Guan , Xianfu Lei , Zhiguo Ding

The brain effortlessly solves blind source separation (BSS) problems, but the algorithm it uses remains elusive. In signal processing, linear BSS problems are often solved by Independent Component Analysis (ICA). To serve as a model of a…

神经与进化计算 · 计算机科学 2021-11-18 Yanis Bahroun , Dmitri B Chklovskii , Anirvan M Sengupta

Integrating high-level context information with low-level details is of central importance in semantic segmentation. Towards this end, most existing segmentation models apply bilinear up-sampling and convolutions to feature maps of…

计算机视觉与模式识别 · 计算机科学 2022-06-20 Hanzhe Hu , Yinbo Chen , Jiarui Xu , Shubhankar Borse , Hong Cai , Fatih Porikli , Xiaolong Wang

This article introduces the conjecture that "mathematics, logic and related disciplines may usefully be understood as information compression (IC) by 'multiple alignment', 'unification' and 'search' (ICMAUS)". As a preparation for the two…

综合数学 · 数学 2007-05-23 J Gerard Wolff

Understanding and extracting the patterns of microscopy images has been a major challenge in the biomedical field. Although trained scientists can locate the proteins of interest within a human cell, this procedure is not efficient and…

计算机视觉与模式识别 · 计算机科学 2020-06-09 Hanke Chen

Background: Exonic splice enhancers are sequences embedded within exons which promote and regulate the splicing of the transcript in which they are located. A class of exonic splice enhancers are the SR proteins, which are thought to…

基因组学 · 定量生物学 2007-05-23 Thomas A. Down , Bernard Leong , Tim J. P. Hubbard