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Considerations regarding clinical effectiveness and cost are essential in comparing the overall value of two treatments. There has been growing interest in methodology to integrate cost and effectiveness measures in order to inform policy…

统计方法学 · 统计学 2019-12-04 Andrew J. Spieker , Nicholas Illenberger , Jason A. Roy , Nandita Mitra

Estimands using the treatment policy strategy for addressing intercurrent events are common in Phase III clinical trials. One estimation approach for this strategy is retrieved dropout whereby observed data following an intercurrent event…

In order for clinicians to manage disease progression and make effective decisions about drug dosage, treatment regimens or scheduling follow up appointments, it is necessary to be able to identify both short and long-term trends in…

定量方法 · 定量生物学 2016-12-06 Norman Poh , Simon Bull , Santosh Tirunagari , Nicholas Cole , Simon de Lusignan

Objective: Blood transfusions, crucial in managing anemia and coagulopathy in ICU settings, require accurate prediction for effective resource allocation and patient risk assessment. However, existing clinical decision support systems have…

Medical triage is the task of allocating medical resources and prioritizing patients based on medical need. This paper introduces the first large-scale public dataset for studying medical triage in the context of asynchronous outpatient…

计算与语言 · 计算机科学 2026-01-21 Joseph Gatto , Parker Seegmiller , Timothy Burdick , Philip Resnik , Roshnik Rahat , Sarah DeLozier , Sarah M. Preum

Adherence can be defined as "the extent to which patients take their medications as prescribed by their healthcare providers"[Osterberg and Blaschke, 2005]. World Health Organization's reports point out that, in developed countries, only…

机器学习 · 计算机科学 2018-11-30 Thomas Janssoone , Clémence Bic , Dorra Kanoun , Pierre Hornus , Pierre Rinder

In realistic scenarios, multivariate timeseries evolve over case-by-case time-scales. This is particularly clear in medicine, where the rate of clinical events varies by ward, patient, and application. Increasingly complex models have been…

机器学习 · 计算机科学 2020-03-06 Jacob Deasy , Ari Ercole , Pietro Liò

Introduction: One of the most important tasks in the Emergency Department (ED) is to promptly identify the patients who will benefit from hospital admission. Machine Learning (ML) techniques show promise as diagnostic aids in healthcare.…

Acute pancreatitis (AP) is a common and potentially life-threatening gastrointestinal disease that imposes a significant burden on healthcare systems. ICU readmissions among AP patients are common, especially in severe cases, with rates…

应用统计 · 统计学 2025-05-22 Shuheng Chen , Yong Si , Junyi Fan , Li Sun , Elham Pishgar , Kamiar Alaei , Greg Placencia , Maryam Pishgar

In this paper, we address the issue of estimating and inferring distributional treatment effects in randomized experiments. The distributional treatment effect provides a more comprehensive understanding of treatment heterogeneity compared…

计量经济学 · 经济学 2025-01-15 Tatsushi Oka , Shota Yasui , Yuta Hayakawa , Undral Byambadalai

Clinical notes contain a large amount of clinically valuable information that is ignored in many clinical decision support systems due to the difficulty that comes with mining that information. Recent work has found success leveraging deep…

机器学习 · 计算机科学 2019-11-13 Justin R. Lovelace , Nathan C. Hurley , Adrian D. Haimovich , Bobak J. Mortazavi

As populations age, the rise of multimorbidity poses a significant healthcare challenge. However, our ability to quantitatively forecast the progression of multimorbidity remains limited. Leveraging a nationwide dataset comprising…

物理与社会 · 物理学 2025-07-29 Katharina Ledebur , Alexandra Kautzky-Willer , Stefan Thurner , Peter Klimek

In the fight against hard-to-treat diseases such as cancer, it is often difficult to discover new treatments that benefit all subjects. For regulatory agency approval, it is more practical to identify subgroups of subjects for whom the…

统计方法学 · 统计学 2014-10-09 Wei-Yin Loh , Xu He , Michael Man

Patients whose transfer to the Intensive Care Unit (ICU) is unplanned are prone to higher mortality rates than those who were admitted directly to the ICU. Recent advances in machine learning to predict patient deterioration have introduced…

机器学习 · 计算机科学 2021-01-26 Julien Grand-Clement , Carri W. Chan , Vineet Goyal , Gabriel Escobar

Under current policy decision making paradigm, we make or evaluate a policy decision by intervening different socio-economic parameters and analyzing the impact of those interventions. This process involves identifying the causal relation…

统计方法学 · 统计学 2020-01-07 Md Saiful Islam , Md Sarowar Morshed , Gary J. Young , Md. Noor-E-Alam

Electronic Health Records (EHRs) aggregate diverse information at the patient level, holding a trajectory representative of the evolution of the patient health status throughout time. Although this information provides context and can be…

机器学习 · 计算机科学 2022-09-12 João Figueira Silva , Sérgio Matos

This study addresses a critical gap in the healthcare system by developing a clinically meaningful, practical, and explainable disease surveillance system for multiple chronic diseases, utilizing routine EHR data from multiple U.S.…

机器学习 · 计算机科学 2025-01-28 Shaheer Ahmad Khan , Muhammad Usamah Shahid , Ahmad Abdullah , Ibrahim Hashmat , Muddassar Farooq

Hypertension is a major risk factor for stroke, cardiovascular disease, and end-stage renal disease, and its prevalence is expected to rise dramatically. Effective hypertension management is thus critical. A particular priority is…

计算机与社会 · 计算机科学 2019-07-02 Ramin Mohammadi , Sarthak Jain , Stephen Agboola , Ramya Palacholla , Sagar Kamarthi , Byron C. Wallace

Electronic Health Records (EHRs) have been heavily used to predict various downstream clinical tasks such as readmission or mortality. One of the modalities in EHRs, clinical notes, has not been fully explored for these tasks due to its…

计算与语言 · 计算机科学 2019-06-05 Bonggun Shin , Julien Hogan , Andrew B. Adams , Raymond J. Lynch , Rachel E. Patzer , Jinho D. Choi

Owing to their inherently interpretable structure, decision trees are commonly used in applications where interpretability is essential. Recent work has focused on improving various aspects of decision trees, including their predictive…

机器学习 · 统计学 2023-05-30 Dimitris Bertsimas , Vassilis Digalakis