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The generalizability of empirical findings to new environments, settings or populations, often called "external validity," is essential in most scientific explorations. This paper treats a particular problem of generalizability, called…

统计方法学 · 统计学 2015-03-06 Judea Pearl , Elias Bareinboim

When assessing causal effects, determining the target population to which the results are intended to generalize is a critical decision. Randomized and observational studies each have strengths and limitations for estimating causal effects…

统计方法学 · 统计学 2022-10-21 Irina Degtiar , Sherri Rose

Generalizability and transportability methods have been proposed to address the external validity bias of randomized clinical trials that results from differences in the distribution of treatment effect modifiers between trial and target…

Generalization methods offer a powerful solution to one of the key drawbacks of randomized controlled trials (RCTs): their limited representativeness. By enabling the transport of treatment effect estimates to target populations subject to…

统计方法学 · 统计学 2025-05-20 Ahmed Boughdiri , Clément Berenfeld , Julie Josse , Erwan Scornet

We take steps towards causally interpretable meta-analysis by describing methods for transporting causal inferences from a collection of randomized trials to a new target population, one-trial-at-a-time and pooling all trials. We discuss…

We introduce z-transportability, the problem of estimating the causal effect of a set of variables X on another set of variables Y in a target domain from experiments on any subset of controllable variables Z where Z is an arbitrary subset…

人工智能 · 计算机科学 2013-09-27 Sanghack Lee , Vasant Honavar

Epidemiologists and applied statisticians often believe that relative effect measures conditional on covariates, such as risk ratios and mean ratios, are ``transportable'' across populations. Here, we examine the identification of causal…

统计方法学 · 统计学 2022-02-24 Issa J. Dahabreh , Sarah E. Robertson , Jon A. Steingrimsson

A fundamental task in AI is providing performance guarantees for predictions made in unseen domains. In practice, there can be substantial uncertainty about the distribution of new data, and corresponding variability in the performance of…

机器学习 · 计算机科学 2025-04-01 Kasra Jalaldoust , Alexis Bellot , Elias Bareinboim

Investigators are increasingly using novel methods for extending (generalizing or transporting) causal inferences from a trial to a target population. In many generalizability and transportability analyses, the trial and the observational…

统计方法学 · 统计学 2022-09-20 Yu-Han Chiu , Issa J. Dahabreh

Trial engagement effects are effects of trial participation on the outcome that are not mediated by treatment assignment. Most work on extending (generalizing or transporting) causal inferences from a randomized trial to a target population…

统计方法学 · 统计学 2024-07-23 Lawson Ung , Tyler J. VanderWeele , Issa J. Dahabreh

Extending (generalizing or transporting) causal inferences from a randomized trial to a target population requires ``generalizability'' or ``transportability'' assumptions, which state that randomized and non-randomized individuals are…

Transporting causal information across populations is a critical challenge in clinical decision-making. Causal modeling provides criteria for identifiability and transportability, but these require knowledge of the causal graph, which…

机器学习 · 统计学 2026-02-03 Konstantina Lelova , Gregory F. Cooper , Sofia Triantafillou

Transporting findings from a study population to a target population is central to evidence-based decision-making in real-world settings. Most existing methods require individual-level data from both populations to account for covariate…

统计方法学 · 统计学 2026-03-04 Ying Sheng , Yifei Sun , Chiung-Yu Huang

Scientists frequently generalize population level causal quantities such as average treatment effect from a source population to a target population. When the causal effects are heterogeneous, differences in subject characteristics between…

统计方法学 · 统计学 2023-06-16 Rui Chen , Guanhua Chen , Menggang Yu

When extending inferences from a randomized trial to a new target population, the transportability condition for conditional difference effect measures is invoked to identify the marginal causal mean difference in the target population.…

统计方法学 · 统计学 2024-07-18 Guanbo Wang , Alexander Levis , Jon Steingrimsson , Issa Dahabreh

A major challenge in research involving artificial intelligence (AI) is the development of algorithms that can find solutions to problems that can generalize to different environments and tasks. Unlike AI, humans are adept at finding…

人工智能 · 计算机科学 2021-10-12 Semir Tatlidil , Yanqi Liu , Emily Sheetz , R. Iris Bahar , Steven Sloman

Recent research in causal inference has made important progress in addressing challenges to the external validity of trial findings. Such methods weight trial participant data to more closely resemble the distribution of effect-modifying…

统计方法学 · 统计学 2024-07-18 Justin M. Clark , Kollin W. Rott , James S. Hodges , Jared D. Huling

Transportability, the ability to maintain performance across populations, is a desirable property of markers of clinical outcomes. However, empirical findings indicate that markers often exhibit varying performances across populations. For…

应用统计 · 统计学 2025-12-01 Mohsen Sadatsafavi , Gavin Pereira , Wenjia Chen

We discuss the identifiability of causal estimands for generalizability and transportability analyses, both under perfect and imperfect adherence to treatment assignment. We consider a setting where the trial data contain information on…

统计方法学 · 统计学 2022-11-10 Issa J. Dahabreh , Sarah E. Robertson , Miguel A. Hernán

Methods for extending -- generalizing or transporting -- inferences from a randomized trial to a target population involve conditioning on a large set of covariates that is sufficient for rendering the randomized and non-randomized groups…

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