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Constraint based methods, such as the Flux Balance Analysis, are widely used to model cellular growth processes without relying on extensive information on the regulatory features. The regulation is instead substituted by an optimization…

最优化与控制 · 数学 2017-06-14 Henning Lindhorst , Sergio Lucia , Rolf Findeisen , Steffen Waldherr

In this paper, we propose a novel approach for the data-driven characterization of power system dynamics. The developed method of Extended Subspace Identification (ESI) is suitable for systems with output measurements when all the dynamics…

系统与控制 · 电气工程与系统科学 2021-10-05 Pranav Sharma , Venkataramana Ajjarapu , Umesh Vaidya

Binary random variables are the building blocks used to describe a large variety of systems, from magnetic spins to financial time series and neuron activity. In Statistical Physics the Kinetic Ising Model has been introduced to describe…

统计力学 · 物理学 2021-05-26 Carlo Campajola , Fabrizio Lillo , Piero Mazzarisi , Daniele Tantari

Process mining has emerged as a way to analyze the behavior of an organization by extracting knowledge from event logs and by offering techniques to discover, monitor and enhance real processes. In the discovery of process models,…

人工智能 · 计算机科学 2017-10-17 David Chapela-Campa , Manuel Mucientes , Manuel Lama

In vitro cell biology experiments are routinely used to characterize cell migration properties under various experimental conditions. These experiments can be interpreted using lattice-based random walk models to provide insight into…

应用物理 · 物理学 2024-06-25 Yihan Liu , David J Warne , Matthew J Simpson

To explain the differentiation of stem cells in terms of dynamical systems theory, models of interacting cells with intracellular protein expression dynamics are analyzed and simulated. Simulations were carried out for all possible protein…

细胞行为 · 定量生物学 2015-06-15 Yusuke Goto , Kunihiko Kaneko

We propose a general modeling framework for marked Poisson processes observed over time or space. The modeling approach exploits the connection of the nonhomogeneous Poisson process intensity with a density function. Nonparametric Dirichlet…

统计方法学 · 统计学 2011-11-02 Matthew A. Taddy , Athanasios Kottas

Dosing models often use differential equations to model biological dynamics. Neural differential equations in particular can learn to predict the derivative of a process, which permits predictions at irregular points of time. However, this…

机器学习 · 计算机科学 2023-06-27 Stav Belogolovsky , Ido Greenberg , Danny Eytan , Shie Mannor

Accurate parameter dependent electro-chemical numerical models for lithium-ion batteries are essential in industrial application. The exact parameters of each battery cell are unknown and a process of estimation is necessary to infer them.…

统计理论 · 数学 2024-04-25 Andrea Petrocchi , Matthias K. Scharrer , Franz Pichler , Stefan Volkwein

In nonlinear panel data models, fixed effects methods are often criticized because they cannot identify average marginal effects (AMEs) in short panels. The common argument is that identifying AMEs requires knowledge of the distribution of…

计量经济学 · 经济学 2024-07-08 Victor Aguirregabiria , Jesus M. Carro

We propose a neural network based approach for extracting models from dynamic data using ordinary and partial differential equations. In particular, given a time-series or spatio-temporal dataset, we seek to identify an accurate governing…

机器学习 · 计算机科学 2019-08-09 Yifan Sun , Linan Zhang , Hayden Schaeffer

We present a theoretical application of an optimal experiment design (OED) methodology to the development of mathematical models to describe the stimulus-response relationship of sensory neurons. Although there are a few related studies in…

神经元与认知 · 定量生物学 2016-10-19 R. Ozgur Doruk , Kechen Zhang

Many biological systems are governed by difference equations and exhibit discrete-time dynamics. Examples include the size of a population when generations are non-overlapping, and the incidence of a disease when infections are recorded at…

种群与进化 · 定量生物学 2025-09-25 Shuyun Jiao , David Waxman

Bayesian experimental design (BED) provides a principled framework for optimizing data collection by choosing experiments that are maximally informative about unknown parameters. However, existing methods cannot deal with the joint…

机器学习 · 统计学 2026-01-30 Sara Pérez-Vieites , Sahel Iqbal , Simo Särkkä , Dominik Baumann

The quality of an estimated nonlinear model highly depends on the data quality that was used for the system identification. By using a Gaussian Process-based optimal input design approach, a so-called space-filling dataset can be generated…

系统与控制 · 电气工程与系统科学 2026-05-13 Máté Kiss , Maarten Schoukens , Roland Tóth

The task of sampling from a probability density can be approached as transporting a tractable density function to the target, known as dynamical measure transport. In this work, we tackle it through a principled unified framework using…

We consider the sequential experimental design problem in the predict-then-optimize paradigm. In this paradigm, the outputs of the prediction model are used as coefficient vectors in a downstream linear optimization problem. Traditional…

机器学习 · 统计学 2026-02-06 Beichen Wan , Mo Liu , Paul Grigas , Zuo-Jun Max Shen

We develop a model in which interactions between nodes of a dynamic network are counted by non homogeneous Poisson processes. In a block modelling perspective, nodes belong to hidden clusters (whose number is unknown) and the intensity…

机器学习 · 统计学 2017-07-11 Marco Corneli , Pierre Latouche , Fabrice Rossi

We introduce CLINE (Computational Learning and Identification of Nullclines), a neural network-based method that uncovers the hidden structure of nullclines from oscillatory time series data. Unlike traditional approaches aiming at direct…

机器学习 · 计算机科学 2025-03-21 Bartosz Prokop , Jimmy Billen , Nikita Frolov , Lendert Gelens

We develop a discrete-time version of the blended dynamics theorem for the use of designing distributed computation algorithms. The blended dynamics theorem enables to predict the behavior of heterogeneous multi-agent systems. Therefore,…

系统与控制 · 电气工程与系统科学 2023-12-01 Jeong Woo Kim , Jin Gyu Lee , Donggil Lee , Hyungbo Shim