相关论文: Modulation of beta oscillations during movement in…

The paper highlights the role of a positive feedback gating mechanism at the cellular level in the robust- ness and modulation properties of rhythmic activities at the circuit level. The results are presented in the context of half-center…

Since the earliest electroencephalography experiments, large scale oscillations have been observed in the mammalian brain. More recently, episodes of oscillation and bursting have been identified not only in the cerebral cortex and…

The extant versions of many basal ganglia models use a `gating' model of dopamine function which enhances input to D1 receptor units and attenuates input to D2 receptor units. There is evidence that this model is unsatisfactory because (a)…

Working memory is responsible for the temporary manipulation and storage of information to support reasoning, learning and comprehension in the human brain. Background oscillations from subcortical structures may drive a gating or switching…

Pancreatic beta cells are coupled excitable oscillators that synchronize their activity via different communication pathways. Their oscillatory activity manifests itself on multiple timescales and consists of bursting electrical activity,…

Here we describe an "information based exchange" model of brain function that ascribes to neocortex, basal ganglia, and thalamus distinct network functions. The model allows us to analyze whole brain system set point measures, such as the…

Periodic neural activity not locked to the stimulus or to motor responses is usually ignored. Here, we present new tools for modeling and quantifying the information transmission based on periodic neural activity that occurs with…

Lateral inhibition resulting from a double-negative feedback loop underlies the assignment of different fates to cells in many developmental processes. Previous studies have shown that the presence of time delays in models of lateral…

Transcranial alternating current stimulation (tACS) is becoming an important method in the field of motor rehabilitation because of its ability to non-invasively influence ongoing brain oscillations at arbitrary frequencies. However,…

Many ion channels spontaneously switch between different levels of activity. Although this behaviour known as modal gating has been observed for a long time it is currently not well understood. Despite the fact that appropriately…

Mounting evidence shows that oscillatory activity is widespread in cell signaling. Here we review some of this recent evidence, focusing on both the molecular mechanisms that potentially underlie such dynamical behavior, and the potential…

We consider a generic class of gene circuits affected by nonlinear extrinsic noise. To address this nonlinearity we introduce a general perturbative methodology based on assuming timescale separation between noise and genes dynamics, with…

Planning and executing volitional actions in the face of conflicting habitual responses is a critical aspect of human behavior. At the core of the interplay between these two control systems lies an override mechanism that can suppress the…

This article presents a simple model of the cortex-basal ganglia-thalamus loop, which is thought to serve for action selection and executions, and reports the results of its implementation. The model is based on the hypothesis that the…

Flexible cognition requires the ability to rapidly detect systematic functions of variables and guide future behavior based on predictions. The model described here proposes a potential framework for patterns of neural activity to detect…

Signal transduction in biological cells is effected by signaling pathways that typically include multiple feedback loops. Here we analyze information transfer through a prototypical signaling module with biochemical feedback. The module…

Models based on the Transformer neural network architecture have seen success on a wide variety of tasks that appear to require complex "cognitive branching" -- or the ability to maintain pursuit of one goal while accomplishing others. In…

The electrophysiology of betacells is at the origin of insulin secretion. Betacells exhibit a complex behaviour upon stimulation with glucose including repeated and uninterrupted bursting. Mathematical modelling is most suitable to improve…

Nonadiabatic removal of an external transverse magnetic field provides a phase-selective mechanism for controlling betatron oscillations in laser wakefield accelerators. When the field is switched off on a timescale shorter than the…

Emulate the gating mechanism of ionic channels in neurons, we present a mathematical model for the time constant of dynamical systems. Our model is an analytical continues function. The analyses give evidence that one can adjust the…