相关论文: Piggy-backing protein domains with Formal Concept …

Protein-protein interaction (PPI) networks consist of the physical and/or functional interactions between the proteins of an organism. Since the biophysical and high-throughput methods used to form PPI networks are expensive,…

DGA-based botnet, which uses Domain Generation Algorithms (DGAs) to evade supervision, has become a part of the most destructive threats to network security. Over the past decades, a wealth of defense mechanisms focusing on domain features…

We present F-PKI, an enhancement to the HTTPS public-key infrastructure (or web PKI) that gives trust flexibility to both clients and domain owners, and enables certification authorities (CAs) to enforce stronger security measures. In…

With increasingly deployed deep neural networks in sensitive application domains, such as healthcare and security, it's essential to understand what kind of sensitive information can be inferred from these models. Most known model-targeted…

Parkinson's disease (PD) is a progressive neurodegenerative disorder that lacks reliable early-stage biomarkers for diagnosis, prognosis, and therapeutic monitoring. While cerebrospinal fluid (CSF) biomarkers, such as alpha-synuclein seed…

Protein-protein interactions (PPIs) are associated with various diseases, including cancer, infections, and neurodegenerative disorders. Obtaining three-dimensional structural information on these PPIs serves as a foundation to interfere…

We present a novel privacy-preserving federated adversarial domain adaptation approach ($\textbf{PrADA}$) to address an under-studied but practical cross-silo federated domain adaptation problem, in which the party of the target domain is…

The growing interest for comparing protein internal dynamics owes much to the realization that protein function can be accompanied or assisted by structural fluctuations and conformational changes. Analogously to the case of functional…

Accurate prediction of drug-target interactions (DTI) is pivotal for drug discovery, yet existing methods often fail to address challenges like cross-domain generalization, cold-start prediction, and interpretability. In this work, we…

Domain generalization(DG) endeavors to develop robust models that possess strong generalizability while preserving excellent discriminability. Nonetheless, pivotal DG techniques tend to improve the feature generalizability by learning…

Drug discovery remains time-consuming, labor-intensive, and expensive, often requiring years and substantial investment per drug candidate. Predicting compound-protein interactions (CPIs) is a critical component in this process, enabling…

Causal discovery is central to inferring causal relationships from observational data. In the presence of latent confounding, algorithms such as Fast Causal Inference (FCI) learn a Partial Ancestral Graph (PAG) representing the true model's…

Classification models play a central role in data-driven decision-making applications such as medical diagnosis, recommendation systems, and risk assessment. Traditional performance metrics, such as accuracy and AUC, focus on overall error…

Recently, the structural controllability theory has been introduced to analyze the Protein-Protein Interaction (PPI) network. The indispensable nodes, which their removal increase the number of driver nodes to control the network, are found…

Nowadays data sets are available in very complex and heterogeneous ways. Mining of such data collections is essential to support many real-world applications ranging from healthcare to marketing. In this work, we focus on the analysis of…

Identifying interactions between proteins is important to understand underlying biological processes. Extracting a protein-protein interaction (PPI) from the raw text is often very difficult. Previous supervised learning methods have used…

Domain generation algorithms (DGAs) are frequently employed by malware to generate domains used for connecting to command-and-control (C2) servers. Recent work in DGA detection leveraged deep learning architectures like convolutional neural…

Recent DeepFake detection methods have shown excellent performance on public datasets but are significantly degraded on new forgeries. Solving this problem is important, as new forgeries emerge daily with the continuously evolving…

Information on protein-protein interactions (PPIs) not only advances our understanding of molecular biology but also provides important clues for target selection in drug discovery and the design of PPI inhibitors. One of the techniques…

Protein-protein interaction (PPI) prediction is an instrumental means in elucidating the mechanisms underlying cellular operations, holding significant practical implications for the realms of pharmaceutical development and clinical…