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By observing reconstituted chromatin by fluorescence microscopy (FM) and atomic force microscopy (AFM), we found that the density of nucleosomes exhibits a bimodal profile, i.e., there is a large transition between the dense and dispersed…

亚细胞过程 · 定量生物学 2015-06-26 Tonau Nakai , Kohji Hizume , Shige. H. Yoshimura , Kunio Takeyasu , Kenichi Yoshikawa

Domain shift in the field of histopathological imaging is a common phenomenon due to the intra- and inter-hospital variability of staining and digitization protocols. The implementation of robust models, capable of creating generalized…

计算机视觉与模式识别 · 计算机科学 2024-12-06 Ilán Carretero , Pablo Meseguer , Rocío del Amor , Valery Naranjo

Recently, a moir\'e material has been proposed in which multiple domains of different topological phases appear in the moir\'e unit cell due to a large moir\'e modulation. Topological properties of such moir\'e materials may differ from…

介观与纳米尺度物理 · 物理学 2023-04-12 Ikuma Tateishi , Motoaki Hirayama

This paper introduces a novel synthetic dataset that captures urban scenes under a variety of weather conditions, providing pixel-perfect, ground-truth-aligned images to facilitate effective feature alignment across domains. Additionally,…

计算机视觉与模式识别 · 计算机科学 2024-12-24 Javier Montalvo , Roberto Alcover-Couso , Pablo Carballeira , Álvaro García-Martín , Juan C. SanMiguel , Marcos Escudero-Viñolo

We investigate the large-scale geometry of the DNA-protein complex of chromatin using a generalized optimality principle, which requires that not only should all sub-parts of a natural process be optimal but also the unfolding of higher…

生物大分子 · 定量生物学 2024-02-16 Subhash Kak

We study one-component fermions in chain lattices with proximity-induced superconducting gap and interparticle short-range interaction, capable of hosting Majorana fermions. By systematically tracking various physical quantities, we show…

超导电性 · 物理学 2015-09-22 Y. -H. Chan , Ching-Kai Chiu , Kuei Sun

Domain Adaptation is a technique to address the lack of massive amounts of labeled data in unseen environments. Unsupervised domain adaptation is proposed to adapt a model to new modalities using solely labeled source data and unlabeled…

计算机视觉与模式识别 · 计算机科学 2021-11-19 Thong Vo , Naimul Khan

Recent reports suggest that a generic supervised deep CNN model trained on a large-scale dataset reduces, but does not remove, dataset bias on a standard benchmark. Fine-tuning deep models in a new domain can require a significant amount of…

计算机视觉与模式识别 · 计算机科学 2014-12-12 Eric Tzeng , Judy Hoffman , Ning Zhang , Kate Saenko , Trevor Darrell

Eukaryotic DNA is packaged into chromatin: one-dimensional arrays of nucleosomes separated by stretches of linker DNA are folded into 30-nm chromatin fibers which in turn form higher-order structures. Each nucleosome, the fundamental unit…

基因组学 · 定量生物学 2011-05-25 Răzvan V. Chereji , Alexandre V. Morozov

Chromatin conformation capture technologies such as Hi-C have revealed that the genome is organized in a hierarchy of structures spanning multiple scales observed at different resolutions. Current algorithms often focus on specific…

基因组学 · 定量生物学 2025-12-22 Vipin Kumar , Roberto Rossini , Jonas Paulsen , Anthony Mathelier

Homography estimation serves as a fundamental technique for image alignment in a wide array of applications. The advent of convolutional neural networks has introduced learning-based methodologies that have exhibited remarkable efficacy in…

计算机视觉与模式识别 · 计算机科学 2023-12-01 Mingzhen Shao , Tolga Tasdizen , Sarang Joshi

Domain walls in correlated charge density wave compounds such as 1T-TaS2 can have distinct localized states which govern physical properties and functionalities of emerging quantum phases. However, detailed atomic and electronic structures…

材料科学 · 物理学 2023-04-11 Park Jae Whan , Lee Jinwon , Yeom Han Woong

The remarkable success of large language models has been driven by dense models trained on massive unlabeled, unstructured corpora. These corpora typically contain text from diverse, heterogeneous sources, but information about the source…

计算与语言 · 计算机科学 2022-05-04 Alexandra Chronopoulou , Matthew E. Peters , Jesse Dodge

The principles underlying the architectural landscape of chromatin beyond the nucleosome level in living cells remains largely unknown despite its potential to play a role in mammalian gene regulation. We investigated the 3-dimensional…

基因组学 · 定量生物学 2012-06-27 Ivan Junier , Ryan Dale , Chunhui Hou , François Képès , Ann Dean

We introduce an overlapping-domain approach to large-area metasurface design, in which each simulated domain consists of a unit cell and overlapping regions from the neighboring cells plus PML absorbers. We show that our approach generates…

光学 · 物理学 2020-01-08 Zin Lin , Steven G. Johnson

Domain generalization aims to enhance the model robustness against domain shift without accessing the target domain. Since the available source domains for training are limited, recent approaches focus on generating samples of novel…

计算机视觉与模式识别 · 计算机科学 2021-08-20 Seogkyu Jeon , Kibeom Hong , Pilhyeon Lee , Jewook Lee , Hyeran Byun

Multidimensional separations data have the capacity to reveal detailed information about complex biological samples. However, data analysis has been an ongoing challenge in the area since the peaks that represent chemical factors may drift…

数值分析 · 数学 2025-02-19 Michael Sorochan Armstrong

Spatial transcriptomics studies are becoming increasingly large and commonplace, necessitating simultaneous analysis of a large number of spatially resolved variables. Correspondingly, a diverse range of methodologies have been proposed to…

定量方法 · 定量生物学 2025-09-09 James Boyle , Gregory Hamm , Eleanor Williams , Robin JG Hartman , Magnus Soderburg , Ian Henry , Michael Casey

We present a novel and hierarchical approach for supervised classification of signals spanning over a fixed graph, reflecting shared properties of the dataset. To this end, we introduce a Convolutional Cluster Pooling layer exploiting a…

机器学习 · 计算机科学 2019-02-14 Angelo Porrello , Davide Abati , Simone Calderara , Rita Cucchiara

In this paper, we tackle the domain adaptive object detection problem, where the main challenge lies in significant domain gaps between source and target domains. Previous work seeks to plainly align image-level and instance-level shifts to…

计算机视觉与模式识别 · 计算机科学 2020-03-23 Chang-Dong Xu , Xing-Ran Zhao , Xin Jin , Xiu-Shen Wei