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Purpose: Beam range control is the essence of radiotherapy with heavy charged particles. In conventional broad-beam delivery, fine range adjustment is achieved by insertion of range shifting and compensating materials. In dosimetry, solid…
Purpose: In treatment planning of charged-particle radiotherapy, patient heterogeneity is conventionally modeled as variable-density water converted from CT images to best reproduce the stopping power, which may lead to inaccuracies in the…
Carbon-ion radiotherapy provides high dose conformity for lung cancer, but its benefit is limited by two sources of uncertainties: interplay between scanned beam delivery and tumor motion, and dose modulation from heterogeneous lung tissue.…
The structure and morphology of polymers are significantly altered upon exposure to high energy gamma irradiation. The present investigation reports the influence of such irradiation of doses in the range of 1 - 30 kGy on the particle size…
We present a theoretical model to study the effect of counterion size on the effective charge, size, and thermodynamic behavior of a single, isolated, and flexible polyelectrolyte (PE) chain. We analyze how altering counterion size modifies…
Carbon ion therapy have the ability to overcome the limitation of convertional radiotherapy due to its most energy deposition in selective depth, usually called Bragg peak, which results in increased biological effectiness. During carbon…
We evaluate the pion-nucleon intermediate-state contribution to the two-photon exchange (TPE) correction in the elastic electron-nucleon scattering within a dispersive framework. We calculate the contribution from all $\pi N$ partial waves…
In carbon-ion radiotherapy, single-beam delivery each day in alternate directions has been commonly practiced for operational efficiency, taking advantage of the Bragg peak and the relative biological effectiveness (RBE) for uniform dose…
We present an exact analytical evaluation of the two-photon exchange (TPE) correction to the elastic lepton-proton differential scattering cross section at low-energies within the framework of heavy-baryon chiral perturbation theory. Our…
Employing the covariant baryon chiral perturbation theory, we calculate the leading and next-to-leading order two-pion exchange (TPE) contributions to $NN$ interaction up to order $O(p^3)$. We compare the so-obtained $NN$ phase shifts with…
Purpose: To present a methodology to analyze the variation of RBE with fractionation from clinical data of tumor control probability (TCP) and to apply it to study the response of prostate cancer to proton therapy. M&M: We analyzed the…
Collider experiments involving nuclei provide a direct means of studying exotic states of nuclear matter. Recent measurements of energy correlators in both proton-nucleus (p-A) and nucleus-nucleus (A-A) collisions reveal sizable…
Nowadays there is a growing interest in Particle Therapy treatments exploiting light ion beams against tumors due to their enhanced Relative Biological Effectiveness and high space selectivity. In particular promising results are obtained…
Thin polypropylene (CH$_2$) fibers have been used for internal experiments in storage rings as an option for hydrogen targets. The change of the hydrogen content due to the radiation dose applied by the circulating proton beam has been…
Carbon ion therapy is one of the most advanced forms of radiotherapy, promising improved efficacy against resistant cancers. However, the high precision offered by the carbon ion Bragg peak requires precise knowledge of the beam range…
Improving effective treatment plans in carbon ion therapy, especially for targeting radioresistant tumors located in deep seated regions while sparing normal tissues, depends on a precise and computationally efficient dose calculation…
A model for beam customization with collimators and a range-compensating filter based on the phase-space theory for beam transport is presented for dose distribution calculation in treatment planning of radiotherapy with protons and heavier…
Two boson exchange (TBE) correction to the cross section for the quasi-elastic charged current $\nu n$ and $\bar{\nu} p$ scattering is evaluated. The TBE is given by $W\gamma$ box diagrams. The calculations are performed for 1 GeV…
A work recently published experimentally demonstrates an increase in the radiobiological efficacy of clinical proton beams when a tumour is treated in the presence of a concentration of 11B. The paper, for the first time, demonstrates the…
Purpose: Recent investigations of radiation-induced contrast enhancements (RICE) in brain tumor patients after proton therapy indicated variability in proton relative biological effectiveness (RBE) and increased radiosensitivity of the…