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Skin tension plays a pivotal role in clinical settings, it affects scarring, wound healing and skin necrosis. Despite its importance, there is no widely accepted method for assessing in vivo skin tension or its natural pre-stretch. This…

The magnitude of force used in a stabbing incident can be difficult to quantify, although the estimate given by forensic pathologists is often seen as `critical' evidence in medico-legal situations. The main objective of this study is to…

软凝聚态物质 · 物理学 2020-09-01 Aisling Ni Annaidh , Marie Cassidy , Michael Curtis , Michel Destrade , Michael D. Gilchrist

Knowing the stress within a soft material is of fundamental interest to basic research and practical applications, such as soft matter devices, biomaterial engineering, and medical sciences. However, it is challenging to measure stress…

软凝聚态物质 · 物理学 2022-01-07 Guo-Yang Li , Artur L. Gower , Michel Destrade , Seok-Hyun Yun

We devise a method to detect and estimate forces in a heterogeneous environment based on experimentally recorded stochastic trajectories. In particular, we focus on systems modeled by the heterogeneous overdamped Langevin equation. Here,…

In this paper a novel approach for a measurement of stresses in a capital, which induce the capital flows between economic systems, is proposed. The proposals appeal to an apparatus offered by the statistical theory of shape. We propose a…

经济学 · 定量金融 2018-02-13 Tadeusz Klecha , Daniel Kosiorowski , Dominik Mielczarek , Jerzy P. Rydlewski

Goal: A limitation in robotic surgery is the lack of force feedback, due to challenges in suitable sensing techniques. To enhance the perception of the surgeons and precise force rendering, estimation of these forces along with tissue…

系统与控制 · 电气工程与系统科学 2025-04-30 Srikar Annamraju , Yuxi Chen , Jooyoung Lim , Inki Kim

Active nematic models explain the topological defects and flow patterns observed in epithelial tissues, but the nature of active stress-whether it is extensile or contractile, a key parameter of the theory-is not well established…

软凝聚态物质 · 物理学 2025-11-11 Jan Rozman , Sumesh P. Thampi , Julia M. Yeomans

Animal cells are active, contractile objects. While bioassays address the molecular characterization of cell contractility, the mechanical characterization of the active forces in cells remains challenging. Here by confronting theoretical…

细胞行为 · 定量生物学 2022-09-14 Hélène Delanoë-Ayari , Nicolas Bouchonville , Marie Courçon , Alice Nicolas

Animal morphogenesis often involves significant shape changes of epithelial tissue sheets. Great progress has been made in understanding the underlying cellular driving forces and their coordination through biomechanical feedback loops.…

软凝聚态物质 · 物理学 2024-09-23 Nikolas H. Claussen , Fridtjof Brauns

In minimally invasive telesurgery, obtaining accurate force information is difficult due to the complexities of in-vivo end effector force sensing. This constrains development and implementation of haptic feedback and force-based automated…

机器人学 · 计算机科学 2024-03-28 Shuyuan Yang , My H. Le , Kyle R. Golobish , Juan C. Beaver , Zonghe Chua

High-quality nanomechanical oscillators can sensitively probe force, mass, or displacement in experiments bridging the gap between the classical and quantum domain. Dynamics of these stochastic systems is inherently determined by the…

The measurement of cellular traction forces on soft elastic substrates has become a standard tool for many labs working on mechanobiology. Here we review the basic principles and different variants of this approach. In general, the…

定量方法 · 定量生物学 2015-06-09 Ulrich S. Schwarz , Jerome R. D. Soine

Rapid developments in streaming data technologies have enabled real-time monitoring of human activity that can deliver high-resolution data on health variables over trajectories or paths carved out by subjects as they conduct their daily…

统计方法学 · 统计学 2024-09-11 Tomoya Wakayama , Sudipto Banerjee

Animal cells in tissues are supported by biopolymer matrices, which typically exhibit highly nonlinear mechanical properties. While the linear elasticity of the matrix can significantly impact cell mechanics and functionality, it remains…

We consider a multiscale approach based on immersed methods for the efficient computational modeling of tissues composed of an elastic matrix (in two or three-dimensions) and a thin vascular structure (treated as a co-dimension two…

数值分析 · 数学 2021-11-18 Luca Heltai , Alfonso Caiazzo

Understanding the mechanical behavior of brain tissue is crucial for advancing both fundamental neuroscience and clinical applications. Yet, accurately measuring these properties remains challenging due to the brain unique mechanical…

Mechanical contributions are crucial regulators of diverse biological processes, yet their \textit{in vivo} measurement remains challenging due to limitations of current techniques, that can be destructive or require complex dedicated…

It has historically been a challenge to perform Bayesian inference in a design-based survey context. The present paper develops a Bayesian model for sampling inference in the presence of inverse-probability weights. We use a hierarchical…

统计方法学 · 统计学 2020-06-24 Yajuan Si , Natesh S. Pillai , Andrew Gelman

Quantifying the in-plane rheology of epithelial monolayers remains challenging due to the difficulty of imposing controlled shear. We introduce a self-driven, rheometer-like assay in which collective migration generates stationary shear…

As an effective method to deliver external materials into biological cells, microinjection has been widely applied in the biomedical field. However, the cognition of cell mechanical property is still inadequate, which greatly limits the…

机器人学 · 计算机科学 2022-11-29 Shengzheng Kang , Zhicheng Song , Xiaolong Yang , Yao Li , Hongtao Wu , Tao Li