相关论文: Biases in the Experimental Annotations of Protein …

The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose here that the increasing complexity of protein-protein…

Protein domains are found on genomes with notable statistical distributions, which bear a high degree of similarity. Previous work has shown how these distributions can be accounted for by simple models, where the main ingredients are…

Large-scale registries have collected vast amounts of data which has enabled investigators to efficiently conduct studies of observational data. Common practice is for investigators to use all data meeting the inclusion criteria of their…

Increasingly used high throughput experimental techniques, like DNA or protein microarrays give as a result groups of interesting, e.g. differentially regulated genes which require further biological interpretation. With the systematic…

Large self-supervised models pretrained on millions of protein sequences have recently gained popularity in generating embeddings of protein sequences for protein function prediction. However, the absence of random baselines makes it…

Scientific output varies between research fields and between disciplines within a field such as astrophysics. Even in fields where publication is the primary output, there is considerable variation in publication and hence in citation…

Autocatalytic fibril nucleation has recently been proposed to be a determining factor for the spread of neurodegenerative diseases, but the same process could also be exploited to amplify minute quantities of protein aggregates in a…

Protein representation learning plays a crucial role in understanding the structure and function of proteins, which are essential biomolecules involved in various biological processes. In recent years, deep learning has emerged as a…

Protein sequence data from nature exhibits survivorship bias: we only observe data from those organisms that survive and reproduce, while non-functional protein mutations are eliminated by natural selection. Thus, predicting whether a…

Quantifying the effects of amino acid mutations in proteins presents a significant challenge due to the vast combinations of residue sites and amino acid types, making experimental approaches costly and time-consuming. The Potts model has…

Accurate annotation of medical image is the crucial step for image AI clinical application. However, annotating medical image will incur a great deal of annotation effort and expense due to its high complexity and needing experienced…

Characterizing genes with semantic information is an important process regarding the description of gene products. In spite that complete genomes of many organisms have been already sequenced, the biological functions of all of their genes…

Data sharing is fundamental to scientific progress, enhancing transparency, reproducibility, and innovation across disciplines. Despite its growing significance, the variability of data-sharing practices across research fields remains…

Inside individual cells, expression of genes is inherently stochastic and manifests as cell-to-cell variability or noise in protein copy numbers. Since proteins half-lives can be comparable to the cell-cycle length, randomness in…

As protein therapeutics play an important role in almost all medical fields, numerous studies have been conducted on proteins using artificial intelligence. Artificial intelligence has enabled data driven predictions without the need for…

Multi-modality pre-training paradigm that aligns protein sequences and biological descriptions has learned general protein representations and achieved promising performance in various downstream applications. However, these works were…

We conducted a large-scale analysis of around 10,000 scientific articles, from the period 2007-2016, to study the bibliometric or formal aspects influencing citations. A transversal analysis was conducted disaggregating the articles into…

Proteins created by combinatorial methods in vitro are an important source of information for understanding sequence-structure-function relationships. Alignments of folded proteins from combinatorial libraries can be analyzed using methods…

Post-training (via supervised fine-tuning) improves instruction-following, but often induces semantic mode collapse by biasing models toward low-entropy fine-tuning data at the expense of the high-entropy pretraining distribution.…

As a key to accessing research impact, citation dynamics underpins research evaluation, scholarly recommendation, and the study of knowledge diffusion. Citation prediction is particularly critical for newborn papers, where early assessment…