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When engagement with a randomized trial is driven by factors that affect the outcome or when trial engagement directly affects the outcome independent of treatment, the average treatment effect among trial participants is unlikely to…

统计方法学 · 统计学 2019-06-27 Issa J. Dahabreh , James M. Robins , Sebastien J-P. A. Haneuse , Miguel A. Hernán

Survival outcomes are common in comparative effectiveness studies and require unique handling because they are usually incompletely observed due to right-censoring. A ``once for all'' approach for causal inference with survival outcomes…

统计方法学 · 统计学 2021-12-21 Shuxi Zeng , Fan Li , Liangyuan Hu , Fan Li

The inferential models (IM) framework provides prior-free, frequency-calibrated, posterior probabilistic inference. The key is the use of random sets to predict unobservable auxiliary variables connected to the observable data and unknown…

统计理论 · 数学 2016-01-26 Ryan Martin , Chuanhai Liu

Mixed Models for Repeated Measures (MMRMs) are ubiquitous when analyzing outcomes of clinical trials. However, the linearity of the fixed-effect structure in these models largely restrict their use to estimating treatment effects that are…

统计方法学 · 统计学 2023-01-23 Lars Lau Raket

In panel experiments, we randomly assign units to different interventions, measuring their outcomes, and repeating the procedure in several periods. Using the potential outcomes framework, we define finite population dynamic causal effects…

统计方法学 · 统计学 2021-05-28 Iavor Bojinov , Ashesh Rambachan , Neil Shephard

Traditional meta-analysis assumes that the effect sizes estimated in individual studies follow a Gaussian distribution. However, this distributional assumption is not always satisfied in practice, leading to potentially biased results. In…

统计方法学 · 统计学 2024-04-23 Wei Liang , Haicheng Huang , Hongsheng Dai , Yinghui Wei

In this work, we propose a modeling procedure for fMRI data analysis using a Bayesian Matrix-Variate Dynamic Linear Model (MVDLM). With this type of model, less complex than the more traditional temporal-spatial models, we are able to take…

应用统计 · 统计学 2020-01-22 Johnatan Cardona Jiménez , Carlos A. de B. Pereira , Victor Fossaluza

The research described herewith is to re-visit the classical doubly robust estimation of average treatment effect by conducting a systematic study on the comparisons, in the sense of asymptotic efficiency, among all possible combinations of…

统计理论 · 数学 2020-06-01 Keli Guo , Chuyun Ye , Jun Fan , Lixing Zhu

How should researchers conduct causal inference when the outcome of interest is latent and measured imperfectly by multiple indicators? We develop a general nonparametric framework for identifying and estimating average treatment effects on…

统计方法学 · 统计学 2026-04-22 Jiawei Fu , Donald P. Green

Randomized experiments are the preferred approach for evaluating the effects of interventions, but they are costly and often yield estimates with substantial uncertainty. On the other hand, in silico experiments leveraging foundation models…

We propose a flexible regression framework to model the conditional distribution of multilevel generalized multivariate functional data of potentially mixed type, e.g. binary and continuous data. We make pointwise parametric distributional…

统计方法学 · 统计学 2024-07-31 Alexander Volkmann , Nikolaus Umlauf , Sonja Greven

Generalized causal effect estimands, including the Mann-Whitney parameter and causal net benefit, provide flexible summaries of treatment effects in randomized experiments with non-Gaussian or multivariate outcomes. We develop a unified…

统计方法学 · 统计学 2026-02-27 Xinyuan Chen , Fan Li

In applications of graphical models, we typically have more information than just the samples themselves. A prime example is the estimation of brain connectivity networks based on fMRI data, where in addition to the samples themselves, the…

机器学习 · 统计学 2017-04-21 Yunqi Bu , Johannes Lederer

We investigate large-sample properties of treatment effect estimators under unknown interference in randomized experiments. The inferential target is a generalization of the average treatment effect estimand that marginalizes over potential…

统计理论 · 数学 2019-10-25 Fredrik Sävje , Peter M. Aronow , Michael G. Hudgens

The restricted mean survival time (RMST) difference offers an interpretable causal contrast to estimate the treatment effect for time-to-event outcomes, yet a wide range of available estimators leaves limited guidance for practice. We…

统计方法学 · 统计学 2026-03-02 Charlotte Voinot , Clément Berenfeld , Imke Mayer , Bernard Sebastien , Julie Josse

The random-effects or normal-normal hierarchical model is commonly utilized in a wide range of meta-analysis applications. A Bayesian approach to inference is very attractive in this context, especially when a meta-analysis is based only on…

统计计算 · 统计学 2020-04-29 Christian Röver

We present a statistical framework that jointly models brain shape and functional connectivity, which are two complex aspects of the brain that have been classically studied independently. We adopt a Riemannian modeling approach to account…

统计方法学 · 统计学 2024-04-26 Eardi Lila , John A. D. Aston

We consider mediated effects of an exposure, X on an outcome, Y, via a mediator, M, under no unmeasured confounding assumptions in the setting where models for the conditional expectation of the mediator and outcome are partially linear. We…

统计方法学 · 统计学 2025-01-08 Oliver Hines , Stijn Vansteelandt , Karla Diaz-Ordaz

There is wide agreement on the importance of implementation data from randomized effectiveness studies in behavioral science; however, there are few methods available to incorporate these data into causal models, especially when they are…

统计方法学 · 统计学 2024-05-17 Sooyong Lee , Adam C Sales , Hyeon-Ah Kang , Tiffany A. Whittaker

We study variants of the average treatment effect on the treated with population parameters replaced by their sample counterparts. For each estimand, we derive the limiting distribution with respect to a semiparametric efficient estimator…

统计方法学 · 统计学 2024-02-12 Andrew Yiu