相关论文: Thick collagen-based 3D matrices including growth …
Neural tissue engineering holds incredible potential to restore functional capabilities to damaged neural tissue. It was hypothesized that patterned and functionalized nanofiber scaffolds could control neurite direction and enhance neurite…
Animal cells in tissues are supported by biopolymer matrices, which typically exhibit highly nonlinear mechanical properties. While the linear elasticity of the matrix can significantly impact cell mechanics and functionality, it remains…
Neurites, the long cellular protrusions that form the routes of the neuronal network are capable to actively extend during early morphogenesis or to regenerate after trauma. To perform this task, they rely on their cytoskeleton for…
Biomaterials are becoming an essential tool in the study and application of stem cell research. Various types of biomaterials enable three-dimensional (3D) culture of stem cells, and, more recently, also enable high-resolution patterning…
Unlike other tissue types, like epithelial tissue, which consist of cells with a much more homogeneous structure and function, the nervous tissue spans in a complex multilayer environment whose topographical features display a large…
We take into account the influence of extracellular signalling on neurite elongation in a model of neurite growth mediated by building proteins (e.g. tubulin). Tubulin production dynamics was supplied by a function describing the influence…
Inspired by biology's most sophisticated computer, the brain, neural networks constitute a profound reformulation of computational principles. Remarkably, analogous high-dimensional, highly-interconnected computational architectures also…
The Extra-Cellular-Matrix (ECM) is a complex interconnected 3D network that provides structural support for the cells and tissues and defines organ architecture key for their healthy functioning. However, the intimate mechanisms by which…
A 3D unit cell model containing eight different spherical particles embedded in a homogeneous strain gradient plasticity (SGP) matrix material is presented. The interaction between particles and matrix is controlled by an interface model…
3D neuron growth and neurodevelopmental disorders (NDDs) deterioration exhibit complex morphological transformations as neurites differentiate into axons and dendrites, forming intricate networks driven by tubulin concentrations and…
Detailed knowledge of mechanical parameters such as cell elasticity, stiffness of the growth substrate, or traction stresses generated during axonal extensions is essential for understanding the mechanisms that control neuronal growth. Here…
In vitro neuronal culture is an important research platform in cellular and network neuroscience. However, neurons cultured on a homogeneous scaffold form dense, randomly connected networks and display excessively synchronized activity;…
Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of…
Working in the framework of morphoelasticity, we develop a model of neurite growth in response to elastic deformation. We decompose the applied stretch into an elastic component and a growth component, and adopt an observationally-motivated…
Structural cellular materials in nature, such as wood, trabecular bone, corals, and dentin combine complex biological functions with structural roles, such as skeletal support and impact protection1,2. They feature complex structural…
Neurodevelopmental disorders (NDDs) have arisen as one of the most prevailing chronic diseases within the US. Often associated with severe adverse impacts on the formation of vital central and peripheral nervous systems during the…
We engineered a microfluidic platform to study the effects of bioactive glass nanoparticles (BGNs) on cell viability under static culture. We incorporated different concentrations of BGNs (1%, 2%, and 3% w/v) in collagen hydrogel (with a…
Cultured stem cells have become a standard platform not only for regenerative medicine and developmental biology but also for biophysical studies. Yet, the characterization of cultured stem cells at the level of morphology and macroscopic…
Hierarchical biomaterials embody nature's intricate design principles, offering advanced functionalities through the complex, multi-level organization of their molecular and nanosized building blocks. However, the comprehensive…
Type I collagen is the main component of the extra-cellular matrix (ECM). In vitro, under a narrow window of physico-chemical conditions, type I collagen self-assembles to form complex supramolecular architectures reminiscent of those found…