相关论文: A genetic variant near olfactory receptor genes in…

Predicting odor's pleasantness simplifies the evaluation of odors and has the potential to be applied in perfumes and environmental monitoring industry. Classical algorithms for predicting odor's pleasantness generally use a manual feature…

The olfactory system employs responses of an ensemble of odorant receptors (ORs) to sense molecules and to generate olfactory percepts. Here we hypothesized that ORs can be viewed as 3D spatial filters that extract molecular features…

Predicting olfactory perception directly from molecular structure is central to fragrance design that plays a role in a wide range of industries, such as perfumery, food and beverage, and health care. Among olfactory attributes, odor…

Our sense of smell relies on sensitive, selective atomic-scale processes that are initiated when a scent molecule meets specific receptors in the nose. However, the physical mechanisms of detection are not clear. While odorant shape and…

Understanding how molecular structure gives rise to odor perception remains a long-standing challenge, with ongoing debate over whether olfaction is primarily governed by molecular shape, vibrational properties, or their interplay at the…

Olfactory receptor usage is highly heterogeneous, with some receptor types being orders of magnitude more abundant than others. We propose an explanation for this striking fact: the receptor distribution is tuned to maximally represent…

Ligands for only two human olfactory receptors are known. One of them, OR1D2, binds to Bourgeonal [Malnic B, Godfrey P-A, Buck L-B (2004) The human olfactory receptor gene family. Proc. Natl. Acad. Sci U. S. A. 101: 2584-2589 and Erratum…

Natural odors typically consist of many molecules at different concentrations. It is unclear how the numerous odorant molecules and their possible mixtures are discriminated by relatively few olfactory receptors. Using an…

Olfactory systems use a small number of broadly sensitive receptors to combinatorially encode a vast number of odors. We propose a method of decoding such distributed representations by exploiting a statistical fact: receptors that do not…

A recent paper in a prominent science magazine claims to show that humans can discriminate at least 1 trillion odors. The authors reached that conclusion after performing just 260 comparisons of two smells, of which about half could be…

Associative learning allows animals to rapidly adapt to changes in the environment. Whether and what aspects of such acquired traits may be transmittable across generations remains unclear. Using prolonged olfactory training and subsequent…

We present a model of a coupled system of the olfactory bulb and cortex. Odor inputs to the epithelium are transformed to oscillatory bulbar activities. The cortex recognizes the odor by resonating to the bulbar oscillating pattern when the…

It is known that if odors are presented to an olfactory receptor neuron (ORN) in a sub-threshold concentration -- i.e., when the average value of the number of the ORN bound receptor proteins (RPs) is insufficient for the generation of…

Advances in neural sensing technology are making it possible to observe the olfactory process in great detail. In this paper, we conceptualize smell from a Data Science and AI perspective, that relates the properties of odorants to how they…

The sense of smell is an important part of living organisms. It assists with the interaction of the living organism with its environment. The mechanism by which smell is detected and identified is not fully known. Earlier, shape theory was…

More than any other species, humans form social ties to individuals who are neither kin nor mates, and these ties tend to be with similar people. Here, we show that this similarity extends to genotypes. Across the whole genome, friends'…

Odor detection underpins food safety, environmental monitoring, medical diagnostics, and many more fields. The current artificial sensors developed for odor detection struggle with complex mixtures while non-invasive recordings lack…

Until today, the exact function of mammalian odorant binding proteins (OBPs) remains a topic of debate. Although their main established function lacks direct evidence in human olfaction, OBPs are traditionally believed to act as odorant…

In vertebrates, olfactory sensory neurons choose only one olfactory receptor to produce out of ~2000 possibilities. The mechanism for how this singular receptor expression occurs is unknown. Here we propose a mechanism that can…

Odor sensory evaluation has a broad application in food, clothing, cosmetics, and other fields. Traditional artificial sensory evaluation has poor repeatability, and the machine olfaction represented by the electronic nose (E-nose) is…