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Biomolecular motors use free energy to drive a variety of cellular tasks, including the transport of cargo, such as vesicles and organelles. We find that the widely-used `constant-force' approximation for the effect of cargo on motor…

统计力学 · 物理学 2023-04-11 Aidan I Brown , David A Sivak

We derive a bound on the efficiency of thermal engines that can be sharper than Carnot's limit. It is a function of statistical correlations between the engine internal state and Hamiltonian, can be saturated even in finite-time cycles, and…

量子物理 · 物理学 2026-04-14 Anna Gabetti , Fabrizio Dolcini , Davide Girolami

By conditioning a stochastic process on the value of an observable, one obtains a new stochastic process with different properties. We apply this idea in the context of active matter, and condition interacting self-propelled particles on…

统计力学 · 物理学 2020-03-04 Francesco Cagnetta , Emil Mallmin

The activity of biological cells is primarily based on chemical reactions and typically modeled as a reaction-diffusion system. Cells are, however, highly crowded with macromolecules, including a variety of molecular machines such as…

生物物理 · 物理学 2018-11-02 Yuichi Togashi

We analyze the performance of a Brownian ratchet in the presence of geometrical constraints. A two-state model that describes the kinetics of molecular motors is used to characterize the energetic cost when the motor proceeds under…

生物物理 · 物理学 2015-06-23 Paolo Malgaretti , Ignacio Pagonabarraga , J. Miguel Rubi

We study a thermal engine model for which Newton's cooling law is obeyed during heat transfer processes. The thermal efficiency and its bounds at maximum output power are derived and discussed. This model, though quite simple, can be…

统计力学 · 物理学 2012-11-30 H. Yan , Hao Guo

A simple flashing ratchet model in two dimensions is proposed to simulate the hand-over-hand motion of two head molecular motors like kinesin. Extensive Langevin simulations of the model are performed. Good qualitative agreement with the…

生物物理 · 物理学 2008-03-18 Javier Munarriz , Juan J. Mazo , Fernando Falo

Recently, multilevel collectively coupled quantum machines like heat engines and refrigerators have been shown to admit performance enhancements in analogy to superradiance. Thus far, investigations of the performance of collective quantum…

量子物理 · 物理学 2024-08-19 Julia Boeyens , Benjamin Yadin , Stefan Nimmrichter

Collective effects have attracted remarkable recent interest, not only for their presence in several systems in nature but also for the possibility of being used for the construction of efficient engine setups. Notwithstanding, little is…

统计力学 · 物理学 2023-12-14 Felipe Hawthorne , B. Cleuren , Carlos E. Fiore

Analytical formulas for effective drift, diffusivity, run times, and run lengths are derived for an intracellular transport system consisting of a cargo attached to two cooperative but not identical molecular motors (for example, kinesin-1…

亚细胞过程 · 定量生物学 2021-01-22 Joseph J. Klobusicky , John Fricks , Peter R. Kramer

As engineering advances toward the nanoscale, understanding design principles for molecular motors becomes increasingly valuable. Many molecular motors consist of coupled components transducing one free-energy source into another. Here, we…

统计力学 · 物理学 2026-02-09 Sara Iranbakhsh , David A. Sivak

The definition of a mobilized system and its efficiency are introduced. The existence of an optimal (maximally efficient) system is proved by an application of Young measures and compensated compactness.

适应与自组织系统 · 物理学 2007-05-23 G. Wolansky

The quest on how to collectively self-organize in order to maximize the survival chances of the members of a social group requires finding an optimal compromise between maximizing the well-being of an individual and that of the group. Here…

软凝聚态物质 · 物理学 2021-12-08 Alexandra V. Zampetaki , Benno Liebchen , Alexei V. Ivlev , Hartmut Löwen

Brownian particles interacting sequentially with distinct temperatures and driving forces at each stroke have been tackled as a reliable alternative for the construction of engine setups. However they can behave very inefficiently depending…

统计力学 · 物理学 2022-12-28 Iago N. Mamede , Angel L. L. Stable , C. E. Fiore

A molecular motor is made of either a single macromolecule or a macromolecular complex. Just like their macroscopic counterparts, molecular motors "transduce" input energy into mechanical work. All the nano-motors considered here operate…

生物物理 · 物理学 2013-07-18 Debashish Chowdhury

We consider the performance of periodically driven stochastic heat engines in the linear response regime. Reaching the theoretical bounds for efficiency and efficiency at maximum power typically requires full control over the design and the…

统计力学 · 物理学 2016-04-20 Michael Bauer , Kay Brandner , Udo Seifert

Transport of intracellular cargo is often mediated by teams of molecular motors that function in a chaotic environment under varying conditions. We show that the motors have unique steady state behavior which enables transport modalities…

亚细胞过程 · 定量生物学 2023-09-19 Shreyas Bhaban , Rachit Srivastava , James Melbourne , Saurav Talukdar , Murti V. Salapaka

We study the effect of a coupling between two motor domains in highly-processive motor protein complexes. A simple stochastic discrete model, in which the two parts of the protein molecule interact through some energy potential, is…

软凝聚态物质 · 物理学 2009-11-11 Evgeny B. Stukalin , Hubert Phillips , Anatoly B. Kolomeisky

Significant improvements have been achieved in motion control systems with the availability of high speed power switches and microcomputers on the market. Even though motor drivers are able to provide high torque control bandwidth under…

系统与控制 · 电气工程与系统科学 2019-07-09 Gorkem Secer

The widely debated feasibility of thermodynamic machines achieving Carnot efficiency at finite power has been convincingly dismissed. Yet, the common wisdom that efficiency can only be optimal in the limit of infinitely-slow processes…

统计力学 · 物理学 2017-07-28 Matteo Polettini , Massimiliano Esposito