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We study the dynamics of the passage of a polymer through a membrane pore (translocation), focusing on the scaling properties with the number of monomers $N$. The natural coordinate for translocation is the number of monomers on one side of…

软凝聚态物质 · 物理学 2009-11-07 Jeffrey Chuang , Yacov Kantor , Mehran Kardar

Polymer translocation through a nanopore in a membrane investigated theoretically. Recent experiments on voltage-driven DNA and RNA translocations through a nanopore indicate that the size and geometry of the pore are important factors in…

统计力学 · 物理学 2009-11-07 Elena Slonkina , Anatoly B. Kolomeisky

Most of the theoretical models describing the translocation of a polymer chain through a nanopore use the hypothesis that the polymer is always relaxed during the complete process. In other words, models generally assume that the…

生物大分子 · 定量生物学 2009-11-13 Michel G. Gauthier , Gary W. Slater

We present event distributions for the polymer translocation obtained by extensive Langevin dynamics simulations. Such distributions have not been reported previously and they provide new understanding of the stochastic characteristics of…

软凝聚态物质 · 物理学 2012-04-13 R. P. Linna , K. Kaski

We investigate the influence of varying confinement on the dynamics of polymer translocation through a cone shaped channel. For this, a linear polymer chain is modeled by a self voiding walks (SAWs) on a square lattice. The cis-side of a…

软凝聚态物质 · 物理学 2024-01-10 Manish Dwivedi , Sumitra Rudra , Sanjay Kumar

Motivated by experiments in which a polynucleotide is driven through a proteinaceous pore by an electric field, we study the diffusive motion of a polymer threaded through a narrow channel with which it may have strong interactions. We show…

生物物理 · 物理学 2009-10-31 David K. Lubensky , David R. Nelson

Using Langevin dynamics simulations, we investigate the dynamics of chaperone-assisted translocation of a flexible polymer through a nanopore. We find that increasing the binding energy $\epsilon$ between the chaperone and the chain and the…

软凝聚态物质 · 物理学 2011-08-26 Wancheng Yu , Kaifu Luo

We consider the translocation of a one-dimensional polymer through a pore channel helped by a motor driven by a dichotomous noise with time exponential correlation. We are interested in the study of the translocation time, mean velocity and…

软凝聚态物质 · 物理学 2012-03-01 Alessandro Fiasconaro , Juan José Mazo , Fernando Falo

We study the diffusion of a linear polymer in the presence of permeable membranes without excluded volume interactions, using scaling theory and Monte Carlo simulations. We find that the average time it takes for a chain with polymerization…

凝聚态物理 · 物理学 2016-08-31 Hyoungsoo Yoon , J. M. Deutsch

Langevin Dynamics simulations of polymer translocation are performed where the polymer is stretched via two opposing forces applied on the first and last monomer before and during translocation. In this setup, polymer translocation is…

软凝聚态物质 · 物理学 2018-08-08 Hendrick W. de Haan , David Sean , Gary W. Slater

DNA translocation through nanopores is one of the most promising strategies for the next-generation sequencing technologies. Most part of experimental and numerical works has focused on polymer translocation biased by electrophoresis, where…

软凝聚态物质 · 物理学 2018-02-07 Timothée Menais

We investigate the dynamics of polymer translocation through nanopores under external driving by 3D Langevin Dynamics simulations, focusing on the scaling of the average translocation time $\tau$ versus the length of the polymer, $\tau\sim…

软凝聚态物质 · 物理学 2010-01-04 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Ralf Metzler

We perform two-dimensional Langevin dynamics simulations of electric-field driven polymer translocation through an attractive nanopore. We investigate the effect of the location of the attractive region using different pore patterns. This…

软凝聚态物质 · 物理学 2015-06-15 F Piguet , D P Foster

We investigate the translocation of stiff polymers in the presence of binding particles through a nanopore by two-dimensional Langevin dynamics simulations. We find that the mean translocation time shows a minimum as a function of the…

软凝聚态物质 · 物理学 2015-06-12 Wancheng Yu , Yiding Ma , Kaifu Luo

We investigate the influence of polymer-pore interactions on the translocation dynamics using Langevin dynamics simulations. An attractive interaction can greatly improve translocation probability. At the same time, it also increases…

软凝聚态物质 · 物理学 2007-10-01 Kaifu Luo , Tapio Ala-Nissila , See-chen Ying , Aniket Bhattacharya

Motivated by recent nanofluidics experiments, we use Brownian dynamics and Monte Carlo simulations to study the conformation, organization and dynamics of two polymer chains confined to a single box-like cavity. The polymers are modeled as…

软凝聚态物质 · 物理学 2021-05-19 James M. Polson , Desiree A. Rehel

Monte Carlo (MC) simulations are used to study the dynamics of polymer translocation through a nanopore in the limit where the translocation rate is sufficiently slow that the polymer maintains a state of conformational quasi-equilibrium.…

软凝聚态物质 · 物理学 2015-06-12 James M. Polson , Anthony C. M. McCaffrey

Using Langevin dynamics simulations, we investigate the dynamics of a flexible polymer translocation into a confined area under a driving force through a nanopore. We choose an ellipsoidal shape for the confinement and consider the…

软凝聚态物质 · 物理学 2012-12-06 Kehong Zhang , Kaifu Luo

We study the conformation and dynamics of a single polymer chain that is pulled by a constant force applied at its one end with the other end free. Such a situation is relevant to the growing technology of manipulating individual…

软凝聚态物质 · 物理学 2015-06-04 Takahiro Sakaue , Takuya Saito , Hirofumi Wada

A polymer chain confined in nano-scale geometry has been used to investigate the underlying mechanism of Nuclear Pore Complex (NPC), where transport of cargoes is directional. It was shown here that depending on the solvent quality (good or…

软凝聚态物质 · 物理学 2017-08-02 Sanjay Kumar , Sanjiv Kumar , Debaprasad Giri , Shesh Nath