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Functional-structural models provide detailed representations of tree growth and their application to forestry seems full of prospects. However, owing to the complexity of tree architecture, parametric identification of such models remains…

Breeding for new crop characteristics and adjusting management practices are critical avenues to mitigate yield loss and maintain yield stability under a changing climate. However, identifying high-performing plant traits and management…

种群与进化 · 定量生物学 2022-06-09 Jennifer Hsiao , Soo-Hyung Kim , Dennis J. Timlin , Nathaniel D. Mueller , Abigail L. S. Swann

The prediction of phenotypic traits using high-density genomic data has many applications such as the selection of plants and animals of commercial interest; and it is expected to play an increasing role in medical diagnostics. Statistical…

统计方法学 · 统计学 2016-09-29 Marco Scutari , Ian Mackay , David Balding

We consider the problem of learning a high-dimensional multi-task regression model, under sparsity constraints induced by presence of grouping structures on the input covariates and on the output predictors. This problem is primarily…

机器学习 · 统计学 2012-05-10 Seunghak Lee , Eric P. Xing

An expression quantitative trait locus (eQTL) is a chromosomal region where genetic variants are associated with the expression levels of certain genes that can be both nearby or distant. The identifications of eQTLs for different tissues,…

基因组学 · 定量生物学 2023-02-24 Jingfei Zhang , Hongyu Zhao

Imaging genetics aims to uncover the hidden relationship between imaging quantitative traits (QTs) and genetic markers (e.g. single nucleotide polymorphism (SNP)), and brings valuable insights into the pathogenesis of complex diseases, such…

统计方法学 · 统计学 2025-04-30 Zhibin Pu , Shufei Ge

Understanding the genetic basis of phenotypic plasticity is crucial for predicting and managing climate change effects on wild plants and crops. Here, we combined crop modeling and quantitative genetics to study the genetic control of oil…

Quantum machine learning (QML) represents a promising frontier in the quantum technologies. In this pursuit of quantum advantage, the quantum kernel method for support vector machine has emerged as a powerful approach. Entanglement, a…

量子物理 · 物理学 2023-11-21 Haiyan Wang

Quantifying organism-level phenotypes, such as growth dynamics and biomass accumulation, is fundamental to understanding agronomic traits and optimizing crop production. However, quality growing data of plants at scale is difficult to…

定量方法 · 定量生物学 2025-07-10 Adam J Riesselman , Evan M Cofer , Therese LaRue , Wim Meeussen

Evolutionary methods have long been useful for analysis and explanation in genetics, biology, ecology, and related fields. In this work, we extend these methods to neural networks, specifically large language models (LLMs), to better…

神经与进化计算 · 计算机科学 2026-05-06 Shannon K. Gallagher , Swati Rallapalli , Tyler Brooks , Chuck Loughin , Michele Sezgin , Ronald Yurko

The studies of large-scale, high-dimensional data in fields such as genomics and neuroscience have injected new insights into science. Yet, despite advances, they are confronting several challenges, often simultaneously: lack of…

统计方法学 · 统计学 2024-01-01 Julien Bodelet , Guillaume Blanc , Jiajun Shan , Graciela Muniz Terrera , Oliver Y. Chen

Plasticity-led evolution is a form of evolution where a change in the environment induces novel traits via phenotypic plasticity, after which the novel traits are genetically accommodated over generations under the novel environment. This…

种群与进化 · 定量生物学 2023-01-18 Eden Tian Hwa Ng , Akira R. Kinjo

Understanding the relationship between genomic variation and variation in phenotypes for quantitative traits such as physiology, yield, fitness or behavior, will provide important insights for both predicting adaptive evolution and for…

Artificial Intelligence (AI) has emerged as a key driver of precision agriculture, facilitating enhanced crop productivity, optimized resource use, farm sustainability, and informed decision-making. Also, the expansion of genome sequencing…

基因组学 · 定量生物学 2024-07-25 Guanjin Wang , Junyu Xuan , Penghao Wang , Chengdao Li , Jie Lu

Plant phenotyping (Guo et al. 2021; Pieruschka et al. 2019) focuses on studying the diverse traits of plants related to the plants' growth. To be more specific, by accurately measuring the plant's anatomical, ontogenetical, physiological…

机器学习 · 计算机科学 2022-01-17 Jun Wu , Elizabeth A. Ainsworth , Sheng Wang , Kaiyu Guan , Jingrui He

Models for genome-wide prediction and association studies usually target a single phenotypic trait. However, in animal and plant genetics it is common to record information on multiple phenotypes for each individual that will be genotyped.…

统计方法学 · 统计学 2014-12-09 Marco Scutari , Phil Howell , David J. Balding , Ian Mackay

Testing the existence of a quantitative trait locus (QTL) effect is an important task in QTL mapping studies. Most studies concentrate on the case where the phenotype distributions of different QTL groups follow normal distributions with…

统计方法学 · 统计学 2025-07-22 Guanfu Liu , Pengfei Li , Yukun Liu , Xiaolong Pu

The preservation of soil health is a critical challenge in the 21st century due to its significant impact on agriculture, human health, and biodiversity. We provide the first deep investigation of the predictive potential of machine…

机器学习 · 统计学 2024-02-20 Rosa Aghdam , Xudong Tang , Shan Shan , Richard Lankau , Claudia Solís-Lemus

High-dimensional time series phenotypic data is becoming increasingly common within plant breeding programmes. However, analysing and integrating such data for genetic analysis and genomic prediction remains difficult. Here we show how…

Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

定量方法 · 定量生物学 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu