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Probe-level microarray data are usually stored in matrices, where the row and column correspond to array and probe, respectively. Scientists routinely summarize each array by a single index as the expression level of each probe set (gene).…

应用统计 · 统计学 2010-09-30 Xingdong Feng , Xuming He

Advances in data collecting technologies in genomics have significantly increased the need for tools designed to study the genetic basis of many diseases. Effective statistical methods should excel in both prediction accuracy and biomarker…

统计方法学 · 统计学 2025-11-13 Anthony-Alexander Christidis , Stefan Van Aelst , Ruben Zamar

Tensor classification has become increasingly crucial in statistics and machine learning, with applications spanning neuroimaging, computer vision, and recommendation systems. However, the high dimensionality of tensors presents significant…

统计方法学 · 统计学 2024-09-24 Elynn Chen , Yuefeng Han , Jiayu Li

Factor models are a class of powerful statistical models that have been widely used to deal with dependent measurements that arise frequently from various applications from genomics and neuroscience to economics and finance. As data are…

统计方法学 · 统计学 2018-08-14 Jianqing Fan , Kaizheng Wang , Yiqiao Zhong , Ziwei Zhu

Motivation: Human genomic datasets often contain sensitive information that limits use and sharing of the data. In particular, simple anonymisation strategies fail to provide sufficient level of protection for genomic data, because the data…

定量方法 · 定量生物学 2019-08-27 Teppo Niinimäki , Mikko Heikkilä , Antti Honkela , Samuel Kaski

In recent years many sparse linear discriminant analysis methods have been proposed for high-dimensional classification and variable selection. However, most of these proposals focus on binary classification and they are not directly…

统计方法学 · 统计学 2015-04-23 Qing Mai , Yi Yang , Hui Zou

Microarray data are often used to determine which genes are differentially expressed between groups, for example, between treatment and control groups. There are methods of determining which genes have a high probability of differential…

定量方法 · 定量生物学 2007-05-23 David R. Bickel

Motivation:Microarray experiments result in large scale data sets that require extensive mining and refining to extract useful information. We demonstrate the usefulness of (nonmetric) multidimensional scaling (MDS) method in analyzing a…

基因组学 · 定量生物学 2009-09-29 Y. -h. Taguchi , Y. Oono

The performance of machine learning and pattern recognition algorithms generally depends on data representation. That is why, much of the current effort in performing machine learning algorithms goes into the design of preprocessing…

机器学习 · 计算机科学 2025-10-28 Fadi Dornaika , Ahmad Khoder , Abdelmalik Moujahid , Wassim Khoder

The effectiveness of supervised learning techniques has made them ubiquitous in research and practice. In high-dimensional settings, supervised learning commonly relies on dimensionality reduction to improve performance and identify the…

机器学习 · 计算机科学 2016-08-11 Chang Liu , Bo Li , Yevgeniy Vorobeychik , Alina Oprea

In this paper, we study randomized reduction methods, which reduce high-dimensional features into low-dimensional space by randomized methods (e.g., random projection, random hashing), for large-scale high-dimensional classification.…

机器学习 · 计算机科学 2015-07-21 Tianbao Yang , Lijun Zhang , Rong Jin , Shenghuo Zhu

Regression models are used for inference and prediction in a wide range of applications providing a powerful scientific tool for researchers and analysts from different fields. In many research fields the amount of available data as well as…

统计方法学 · 统计学 2018-06-08 Aliaksandr Hubin , Geir Storvik , Florian Frommlet

Latent variable models represent a useful tool for the analysis of complex data when the constructs of interest are not observable. A problem related to these models is that the integrals involved in the likelihood function cannot be solved…

统计方法学 · 统计学 2015-03-05 Silvia Bianconcini , Silvia Cagnone , Dimitris Rizopoulos

Manifold learning is used for dimensionality reduction, with the goal of finding a projection subspace to increase and decrease the inter- and intraclass variances, respectively. However, a bottleneck for subspace learning methods often…

机器学习 · 计算机科学 2021-05-26 Parisa Abdolrahim Poorheravi , Vincent Gaudet

This paper investigates the effectiveness of using the Random Projection Ensemble (RPE) approach in Quadratic Discriminant Analysis (QDA) for ultrahigh-dimensional classification problems. Classical methods such as Linear Discriminant…

统计方法学 · 统计学 2025-07-10 Annesha Deb , Minerva Mukhopadhyay , Subhajit Dutta

Raman spectroscopy is an important characterization tool with diverse applications in many areas of research. We propose a machine learning method for predicting polarizabilities with the goal of providing Raman spectra from molecular…

材料科学 · 物理学 2024-02-02 Manuel Grumet , Clara von Scarpatetti , Tomáš Bučko , David A. Egger

Because of high dimensionality, correlation among covariates, and noise contained in data, dimension reduction (DR) techniques are often employed to the application of machine learning algorithms. Principal Component Analysis (PCA), Linear…

机器学习 · 统计学 2019-10-08 Katherine C. Kempfert , Yishi Wang , Cuixian Chen , Samuel W. K. Wong

Big data applications, such as medical imaging and genetics, typically generate datasets that consist of few observations n on many more variables p, a scenario that we denote as p>>n. Traditional data processing methods are often…

数据分析、统计与概率 · 物理学 2016-05-18 Magnus O. Ulfarsson , Frosti Palsson , Jakob Sigurdsson , Johannes R. Sveinsson

Single-cell RNA sequencing allows the quantification of gene expression at the individual cell level, enabling the study of cellular heterogeneity and gene expression dynamics. Dimensionality reduction is a common preprocessing step…

统计计算 · 统计学 2025-10-14 Cristian Castiglione , Alexandre Segers , Lieven Clement , Davide Risso

This paper studies the dimension effect of the linear discriminant analysis (LDA) and the regularized linear discriminant analysis (RLDA) classifiers for large dimensional data where the observation dimension $p$ is of the same order as the…

统计理论 · 数学 2018-09-24 Cheng Wang , Binyan Jiang