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Integrating optical diffraction tomography with imaging flow cytometry enables label-free quantifications of the three-dimensional (3D) morphology and hemoglobin content of red blood cells (RBCs) in their natural form. Self-rotation of RBCs…

医学物理 · 物理学 2023-09-28 Yu-Hsiang Chang , Yang-Hsien Lin , Kung-Bin Sung

The distribution of Red Blood Cells in a confined channel flow is inhomogeneous and shows a marked depletion near the walls due to a competition between migration away from the walls and shear-induced diffusion resulting from interactions…

Understanding how red blood cell (RBC) suspensions navigate porous materials is critical for for both fundamental physiology, such as maternal-fetal exchange in the placenta, and transformative biomedical applications, including rapid,…

软凝聚态物质 · 物理学 2025-09-03 Sampad Laha , Ananta Kumar Nayak , Alexander Farutin , Suman Chakraborty , Chaouqi Misbah

Via computer simulations, we provide evidence that the shear rate induced red blood cell tumbling-to-tank-treading transition also occurs at quite high volume fractions, where collective effects are important. The transition takes place as…

软凝聚态物质 · 物理学 2013-12-13 Timm Krüger , Markus Gross , Dierk Raabe , Fathollah Varnik

Biconcave-discoid (empirical shape of a red blood cell) capsule finds numerous applications in the field of bio-fluid dynamics and rheology, apart from understanding the behavior of red blood cells (RBC) in blood flow. A detailed analysis…

软凝聚态物质 · 物理学 2018-12-11 Sudip Das , Shivraj D. Deshmukh , Rochish M Thaokar

Computational Fluid Dynamics (CFD) is currently used to design and improve the hydraulic properties of biomedical devices, wherein the large scale blood circulation needs to be simulated by accounting for the mechanical response of red…

流体动力学 · 物理学 2024-12-24 F. Guglietta , M. Behr , L. Biferale , G. Falcucci , M. Sbragaglia

Mesoscopic numerical simulations provide a unique approach for the quantification of the chemical influences on red blood cell functionalities. The transport Dissipative Particles Dynamics (tDPD) method can lead to such effective multiscale…

计算物理 · 物理学 2017-06-07 Ansel L. Blumers , Yu-Hang Tang , Zhen Li , Xuejin Li , George E. Karniadakis

The manual evaluation, classification and counting of biological objects demands for an enormous expenditure of time and subjective human input may be a source of error. Investigating the shape of red blood cells (RBCs) in microcapillary…

生物物理 · 物理学 2018-06-22 Alexander Kihm , Lars Kaestner , Christian Wagner , Stephan Quint

Cell dynamics simulation is used to investigate the phase behavior of block copolymer/homopolymer mixture subjected to a steady shear flow. Phase transitions occur from transverse to parallel and then to perpendicular lamellar structure…

软凝聚态物质 · 物理学 2015-06-29 Y. Guo , J. Zhang , B. Wang , H. Wu , M. Sun , J. Pan

The dynamics and rheology of suspensions of fluid vesicles or red blood cells is investigated by a combination of molecular dynamics and mesoscale hydrodynamics simulations in two dimensions. The vesicle suspension is confined between two…

软凝聚态物质 · 物理学 2013-05-03 A. Lamura , G. Gompper

We study the rheology of a suspension of soft deformable droplets subjected to a pressure-driven flow. Through computer simulations, we measure the apparent viscosity as a function of droplet concentration and pressure gradient, and provide…

软凝聚态物质 · 物理学 2017-11-22 M. Foglino , A. N. Morozov , O. Henrich , D. Marenduzzo

A mixed suspension of red blood cells (RBCs) and microparticles flows through a cylindrical channel with a constriction mimicking a stenosed blood vessel. Our three-dimensional Lattice-Boltzmann simulations show that the RBCs are depleted…

流体动力学 · 物理学 2017-02-01 Christian Bächer , Lukas Schrack , Stephan Gekle

Cardiac disease and clinical intervention may both lead to an increased risk for thrombosis events due to modified blood flow in the heart, and thereby a change in the mechanical stimuli of blood cells passing through the chambers of the…

Microfluidic technologies are commonly used for the manipulation of red blood cell (RBC) suspensions and analyses of flow-mediated biomechanics. To enhance the performance of microfluidic devices, understanding the dynamics of the…

We present a numerical analysis of the lateral movement and equilibrium radial positions of red blood cells (RBCs) with major diameter of 8 $\mu$m under a Newtonian fluid in a circular channel with 50-$\mu$m diameter. Each RBC, modelled as…

In this paper, we present a spatio-temporal mathematical model for simulating the formation and growth of a thrombus. Blood is treated as a multi-constituent mixture comprised of a linear fluid phase and a thrombus (solid) phase. The…

The flow behavior of blood in microvessels is directly associated with tissue perfusion and oxygen delivery. Current efforts on modeling blood flow have primarily focused on the flow properties of blood with red blood cells (RBCs) having a…

软凝聚态物质 · 物理学 2024-06-03 Wei Chien , Gerhard Gompper , Dmitry A. Fedosov

The microvascular networks in the body of vertebrates consist of the smallest vessels such as arterioles, capillaries, and venules. The flow of RBCs through these networks ensures the gas exchange in as well as the transport of nutrients to…

生物物理 · 物理学 2021-02-26 A. Kihm , S. Quint , M. W. Laschke , M. D. Menger , T. John , L. Kaestner , C. Wagner

In this fluid dynamics video we show simulations of droplet breakup and collisions in simple shear flow. Due to the high resolution of the GPU-based simulations, we capture the transition from coalescence at low capillary numbers to sliding…

流体动力学 · 物理学 2012-10-16 Orest Shardt , Alexandra Komrakova , J. J. Derksen , Sushanta K. Mitra

Application of computation in many fields are growing fast in last two decades. Increasing on computation performance helps researchers to understand natural phenomena in many fields of science and technology including in life sciences.…

生物物理 · 物理学 2014-02-27 Suprijadi , Mohamad Rendi , Petrus Subekti , Sparisoma Viridi