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Graph neural networks (GNNs) have emerged as a powerful tool for learning software engineering tasks including code completion, bug finding, and program repair. They benefit from leveraging program structure like control flow graphs, but…

机器学习 · 计算机科学 2020-10-27 David Bieber , Charles Sutton , Hugo Larochelle , Daniel Tarlow

Single-cell RNA sequencing (scRNA-seq) technology provides high-throughput gene expression data to study the cellular heterogeneity and dynamics of complex organisms. Graph neural networks (GNNs) have been widely used for automatic cell…

机器学习 · 计算机科学 2023-12-19 Rui Yang , Wenrui Dai , Chenglin Li , Junni Zou , Dapeng Wu , Hongkai Xiong

Predicting genetic perturbations enables the identification of potentially crucial genes prior to wet-lab experiments, significantly improving overall experimental efficiency. Since genes are the foundation of cellular life, building gene…

定量方法 · 定量生物学 2025-05-09 Changxi Chi , Jun Xia , Jingbo Zhou , Jiabei Cheng , Chang Yu , Stan Z. Li

There are many mathematical models of biochemical cell signaling pathways that contain a large number of elements (species and reactions). This is sometimes a big issue for identifying critical model elements and describing the model…

分子网络 · 定量生物学 2021-09-15 Hemn Mohammed Rasool , Sarbaz H. A. Khoshnaw

In Model-Based Systems Engineering (MBSE), the Systems Modeling Language (SysML) specification includes a metamodel that defines the language concepts and a user model that defines how the language concepts are represented. In SysML, an…

软件工程 · 计算机科学 2021-11-10 William S. Chao

Objective: The paper focuses on development of robust and accurate processing solutions for continuous and cuff-less blood pressure (BP) monitoring. In this regard, a robust deep learning-based framework is proposed for computation of low…

机器学习 · 计算机科学 2022-01-03 Soheil Zabihi , Elahe Rahimian , Fatemeh Marefat , Amir Asif , Pedram Mohseni , Arash Mohammadi

Biological systems typically involve large numbers of components with complex, highly parallel interactions and intrinsic stochasticity. To model this complexity, numerous programming languages based on process calculi have been developed,…

编程语言 · 计算机科学 2010-11-03 Andrew Phillips , Matthew Lakin , Loïc Paulevé

Invariance-based and generative methods have shown a conspicuous performance for 3D self-supervised representation learning (SSRL). However, the former relies on hand-crafted data augmentations that introduce bias not universally applicable…

计算机视觉与模式识别 · 计算机科学 2024-09-25 Naiwen Hu , Haozhe Cheng , Yifan Xie , Shiqi Li , Jihua Zhu

Boundary Representation (B-Rep) is the widely adopted standard in Computer-Aided Design (CAD) and manufacturing. However, generative modeling of B-Reps remains a formidable challenge due to their inherent heterogeneity as geometric cell…

计算机视觉与模式识别 · 计算机科学 2026-01-27 Junran Lu , Yuanqi Li , Hengji Li , Jie Guo , Yanwen Guo

Graph neural networks (GNNs) have become the state of the art for various graph-related tasks and are particularly prominent in heterogeneous graphs (HetGs). However, several issues plague this paradigm: first, the difficulty in fully…

机器学习 · 计算机科学 2025-02-25 Xuqi Mao , Zhenying He , X. Sean Wang

Scientific diagrams convey explicit structural information, yet modern text-to-image models often produce visually plausible but structurally incorrect results. Existing benchmarks either rely on image-centric or subjective metrics…

计算机视觉与模式识别 · 计算机科学 2026-02-11 Tong Zhang , Honglin Lin , Zhou Liu , Chong Chen , Wentao Zhang

Modern single-cell flow and mass cytometry technologies measure the expression of several proteins of the individual cells within a blood or tissue sample. Each profiled biological sample is thus represented by a set of hundreds of…

机器学习 · 计算机科学 2022-06-29 Siyuan Shan , Vishal Baskaran , Haidong Yi , Jolene Ranek , Natalie Stanley , Junier Oliva

We present a novel system that automatically extracts and generates informative and descriptive sentences from the biomedical corpus and facilitates the efficient search for relational knowledge. Unlike previous search engines or…

计算与语言 · 计算机科学 2023-10-19 Kerui Zhu , Jie Huang , Kevin Chen-Chuan Chang

Graph Neural Networks (GNNs) have shown promise in learning dynamic functional connectivity for distinguishing phenotypes from human brain networks. However, obtaining extensive labeled clinical data for training is often…

机器学习 · 计算机科学 2025-05-06 Jungwon Choi , Hyungi Lee , Byung-Hoon Kim , Juho Lee

The pathway is a biological term that refers to a series of interactions between molecules in a cell that causes a certain product or a change in the cell. Pathway analysis is a powerful method for gene expression analysis. Through pathway…

数据结构与算法 · 计算机科学 2022-01-11 Lingran Xiao , Yanfei Wang , Shiying Li , Lingxi Chen , Shuaicheng Li

Blind Image Quality Assessment (BIQA) is a fundamental task in computer vision, which however remains unresolved due to the complex distortion conditions and diversified image contents. To confront this challenge, we in this paper propose a…

计算机视觉与模式识别 · 计算机科学 2023-04-12 Guanyi Qin , Runze Hu , Yutao Liu , Xiawu Zheng , Haotian Liu , Xiu Li , Yan Zhang

In biochemical systems some of the chemical species are present with only small numbers of molecules. In this situation discrete and stochastic simulation approaches are more relevant than continuous and deterministic ones. The fundamental…

计算工程、金融与科学 · 计算机科学 2013-03-18 Tae-Hyuk Ahn , Adrian Sandu , Xiaoying Han

Business Process Model and Notation (BPMN) provides a standard for the design of business processes. It focuses on bridging the gap between the analysis and the technical perspectives, and aims to deliver process automation. The aim of this…

数据库 · 计算机科学 2015-09-01 Anastasios Gounaris

Quantum computers are expected to perform the full-configuration interaction calculations with less computational resources compared to classical ones, thanks to the use of the quantum phase estimation (QPE) algorithms. However, only a…

量子物理 · 物理学 2024-12-05 Yusuke Ino , Misaki Yonekawa , Hideto Yuzawa , Yuichiro Minato , Kenji Sugisaki

Graph neural networks (GNNs) are increasingly used to model biological systems, yet the reliability of post-hoc explanation methods for recovering meaningful molecular mechanisms remains unclear. Here, we systematically evaluate four widely…

分子网络 · 定量生物学 2026-05-22 Kyle Higgins , Ivan Laponogov , Dennis Veselkov , Kirill Veselkov