相关论文: Aging as a consequence of misrepair -- a novel the…

Aging is a fundamental aspect of living systems that undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. Living systems, known as complex systems, require complexity…

Physical aging is one of the non-equilibrium phenomena where physical properties change over time due to structural relaxation. Aging in spin glass systems has been explained by a trap model on the temperature-independent energy landscape.…

The gradual accumulation of damage and dysregulation during the aging of living organisms can be quantified. Even so, the aging process is complex and has multiple interacting physiological scales -- from the molecular to cellular to whole…

What is aging? Mechanistic answers to this question remain elusive despite decades of research. Here, we propose a mathematical model of cellular aging based on a model gene interaction network. Our network model is made of only non-aging…

Many complex and disordered systems fail to reach equilibrium after they have been quenched or perturbed. Instead, they sluggishly relax toward equilibrium at an ever-slowing, history-dependent rate, a process termed physical aging. The…

Alzheimer's disease is not the outcome of a single cause but the convergence of many. This review reframes dementia as a systemic failure, where amyloid plaques and tau tangles are not root causes but late-stage byproducts of the underlying…

Many real-world complex networks arise as a result of a competition between growth and rewiring processes. Usually the initial part of the evolution is dominated by growth while the later one rather by rewiring. The initial growth allows…

A multiphasic constitutive model of the skin that implicitly accounts for the process of intrinsic (i.e.\ chronological) ageing via variation of the constitutive parameters is proposed. The structurally-motivated constitutive formulation…

Motivated by the wide range of known self-replicating systems, some far from genetics, we study a system composed by individuals having an internal dynamics with many possible states that are partially stable, with varying mutation rates.…

Aging, as defined in terms of the slope of the probability of death versus time (hazard curve), is a generic phenomenon observed in nearly all complex systems. Theoretical models of aging predict hazard curves that monotonically increase in…

We increasingly rely on the network approach to understand the complexity of cellular functions. Chaperones (heat shock proteins) are key "networkers", which have among their functions to sequester and repair damaged protein. In order to…

Many complex systems experience damage accumulation which leads to aging, manifest as an increasing probability of system collapse with time. This naturally raises the question of how to maximize health and longevity in an aging system at…

In this paper authors present a general methodology for age dependent reliability analysis of degrading or ageing systems, structures and components.The methodology is based on Bayesian methods and inference, its ability to incorporate…

Understanding the emergence and evolution of multicellularity and cellular differentiation is a core problem in biology. We develop a quantitative model that shows that a multicellular form emerges from genetically identical unicellular…

Advances in healthcare and in the quality of life significantly increase human life expectancy. With the ageing of populations, new un-faced challenges are brought to science. The human body is naturally selected to be well-functioning…

Models of many-species ecosystems, such as the Lotka-Volterra and replicator equations, suggest that these systems generically exhibit near-extinction processes, where population sizes go very close to zero for some time before rebounding,…

Advanced-Glycation-Endproducts (AGEs) are known to be a major cause of impaired tissue material properties. In collagen fibrils, the main building component of human tissue, these AGEs appear as fibrillar cross-links. When AGEs accumulate…

In this paper, we explore the reduction of functionality in a complex system as a consequence of cumulative random damage and imperfect reparation, a phenomenon modeled as a dynamical process on networks. We analyze the global…

There has been a recent surge of interest in what causes aging. This has been matched by unprecedented research investment in the field from tech companies. But, despite considerable effort from a broad range of researchers, we do not have…

In these lecture notes I describe some of the main theoretical ideas emerged to explain the aging dynamics. This is meant to be a very short introduction to aging dynamics and no previous knowledge is assumed. I will go through simple…