相关论文: Possible mechanisms for initiating macroscopic lef…
The development of multicellular organisms proceeds through a series of morphogenetic and cell-state transitions, transforming homogeneous zygotes into complex adults by a process of self-organization. Many of these transitions are achieved…
In this review, we discuss modularity and hierarchy in biological systems. We review examples from protein structure, genetics, and biological networks of modular partitioning of the geometry of biological space. We review theories to…
Biological cells exhibit a hierarchical spatial organization, where various compartments harbor condensates that form by phase separation. Cells can control the emergence of these condensates by affecting compartment size, the amount of the…
Chiral molecules with broken parity symmetries can be modeled as quantum systems with cyclic-transition structures. By using these novel properties, we design two-step laser pulses to distinguish left- and right-handed molecules from the…
Non-genetic forms of antimicrobial drug resistance can result from cell-to-cell variability that is not encoded in the genetic material. Data from recent studies also suggest that non-genetic mechanisms can facilitate the development of…
Meaningful laws of nature must be independent of the units employed to measure the variables. The principle of similitude (Rayleigh 1915) or dimensional homogeneity, states that only commensurable quantities (ones having the same dimension)…
A fresh analysis of Left right symmetric supersymmetric models in the generic case where the scale of right handed symmetry breaking $M_R >> M_{SUSY}\sim M_W$ is presented. We conclude that the low energy effective theory for such models is…
While fields like Artificial Life have made huge strides in quantifying the mechanisms that distinguish living systems from non-living ones, particular mechanisms remain difficult to reproduce in silico. Known as open-endedness, we've been…
We extend a previously theory for the interspecific allometric scaling developed in a $d+1$-dimensional space of metabolic states. The time, which is characteristic of all biological processes, is included as an extra dimension to $d$…
Successful leptogenesis within the conventional TeV-scale left-right implementation of type-I seesaw has been shown to require that the mass of the right-handed $W_R^\pm$ boson should have a lower bound much above the reach of the Large…
Left-right axis specification establishes embryonic laterality through asymmetric signaling cascades originating at the cellular scale. We previously reported the presence of a directionality bias in confined pairs of endothelial (and…
The cells and tissues that make up our body juggle contradictory mechanical demands. It is crucial for their survival to be able to withstand large mechanical loads, but it is equally crucial for them to produce forces and actively change…
Multimodal normal incestual systems are investigated in terms of multiple categories. The different sorted composition of operators are exhibited as 2-cells in multiple categories built up from 2-categories giving rise to different axioms.…
Understanding the rules underlying organismal development is a major unsolved problem in biology. Each cell in a developing organism responds to signals in its local environment by dividing, excreting, consuming, or reorganizing, yet how…
A symmetry is a `change without change'. As simple as it sounds, this concept is the fundamental cornerstone that unifies all branches of theoretical physics. Virtually all physical laws -- ranging from classical mechanics and…
Our knowledge of how individual cells self-organize to form complex multicellular systems is being revolutionized by a data outburst, coming from high-throughput experimental breakthroughs such as single-cell RNA sequencing and spatially…
We study the influence of lepton asymmetry on the evolution of the early Universe. The lepton asymmetry $l$ is poorly constrained by observations and might be orders of magnitude larger than the baryon asymmetry $b$, $|l|/b \leq 2\times…
We discuss an anthropic explanation of why there exist three generations of fermions. If one assumes that the right-handed neutrino sector is responsible for both the matter-antimatter asymmetry and the dark matter, then anthropic selection…
Biological and social systems are structured at multiple scales, and the incentives of individuals who interact in a group may diverge from the collective incentive of the group as a whole. Mechanisms to resolve this tension are responsible…
Active matter has played a pivotal role in advancing our understanding of non-equilibrium systems, leading to a fundamental shift in the study of biophysical phenomena. The foundation of active matter research is built on assumptions…