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Mitogen-activated protein kinase (MAPK) signaling pathways play an essential role in the transduction of environmental stimuli to the nucleus, thereby regulating a variety of cellular processes, including cell proliferation, differentiation…

分子网络 · 定量生物学 2014-03-27 Mercedes Pérez Millán , Adrián G. Turjanski

Controlling spatial patterns in synthetic biological systems remains challenging due to poor parameter robustness and limited experimental tunability. We introduce two complementary mechanisms-the pattern switch and the pattern dial-to…

生物物理 · 物理学 2025-12-02 Antonio Matas-Gil , Robert G. Endres

To gain a deeper understanding of the behavior and learning dynamics of (deep) artificial neural networks, it is valuable to employ mathematical abstractions and models. These tools provide a simplified perspective on network performance…

机器学习 · 计算机科学 2023-08-03 Stephan Johann Lehmler , Muhammad Saif-ur-Rehman , Tobias Glasmachers , Ioannis Iossifidis

We present exact results, as well as some illustrative Monte Carlo simulations, concerning a stochastic network with weighted connections in which the fraction of nodes that are dynamically synchronized is a parameter. This allows one to…

无序系统与神经网络 · 物理学 2007-05-23 J. Marro , J. J. Torres , J. M. Cortes , B. Wemmenhove

Networks of coupled phase oscillators are one of the most studied dynamical systems with numerous applications in physics, chemistry, biology, and engineering. Their behaviour is often characterized by the emergence of various partially…

斑图形成与孤子 · 物理学 2026-02-27 Oleh E. Omel'chenko

This paper proposes an attributed network growth model. Despite the knowledge that individuals use limited resources to form connections to similar others, we lack an understanding of how local and resource-constrained mechanisms explain…

社会与信息网络 · 计算机科学 2019-04-17 Harshay Shah , Suhansanu Kumar , Hari Sundaram

We consider the problem of optimal distributed beamforming in a sensor network where the sensors observe a dynamic parameter in noise and coherently amplify and forward their observations to a fusion center (FC). The FC uses a Kalman filter…

信息论 · 计算机科学 2013-04-02 Feng Jiang , Jie Chen , A. Lee Swindlehurst

We investigate the effectiveness of tuning HMC parameters using information from the gradients of the HMC acceptance probability with respect to the parameters. In particular, the optimization of the trajectory length and parameters for…

高能物理 - 格点 · 物理学 2024-02-08 James C. Osborn

A ubiquitous building block of signaling pathways is a cycle of covalent modification (e.g., phosphorylation and dephosphorylation in MAPK cascades). Our paper explores the kind of information processing and filtering that can be…

分子网络 · 定量生物学 2015-05-13 Carlos Gomez-Uribe , George C. Verghese , Leonid A. Mirny

Most uses of machine learning today involve training a model from scratch for a particular task, or sometimes starting with a model pretrained on a related task and then fine-tuning on a downstream task. Both approaches offer limited…

机器学习 · 计算机科学 2022-05-26 Andrea Gesmundo , Jeff Dean

The propagation of an initially localized perturbation via an interacting many-particle Hamiltonian dynamics is investigated. We argue that the propagation of the perturbation can be captured by the use of a continuous-time random walk…

统计力学 · 物理学 2012-09-11 V. Zaburdaev , S. Denisov , P. Hanggi

Legged locomotion is a challenging task in the field of robotics but a rather simple one in nature. This motivates the use of biological methodologies as solutions to this problem. Central pattern generators are neural networks that are…

神经与进化计算 · 计算机科学 2020-03-18 Elie Aljalbout , Florian Walter , Florian Röhrbein , Alois Knoll

We use a simple model to extend network models for activated dynamics to a continuous landscape with a well-defined notion of distance and a direct connection to many-body systems. The model consists of a tracer in a high-dimensional funnel…

无序系统与神经网络 · 物理学 2020-05-13 Matthew R. Carbone , Valerio Astuti , Marco Baity-Jesi

A new approach for efficiently exploring the configuration space and computing the free energy of large atomic and molecular systems is proposed, motivated by an analogy with reinforcement learning. There are two major components in this…

化学物理 · 物理学 2018-04-18 Linfeng Zhang , Han Wang , Weinan E

The structure of a network has a major effect on dynamical processes on that network. Many studies of the interplay between network structure and dynamics have focused on models of phenomena such as disease spread, opinion formation and…

动力系统 · 数学 2025-10-21 Lucas Böttcher , Mason A. Porter

Parameter management is essential for distributed training of large machine learning (ML) tasks. Some ML tasks are hard to distribute because common approaches to parameter management can be highly inefficient. Advanced parameter management…

机器学习 · 计算机科学 2023-08-21 Alexander Renz-Wieland , Andreas Kieslinger , Robert Gericke , Rainer Gemulla , Zoi Kaoudi , Volker Markl

Network structure is growing popular for capturing the intrinsic relationship between large-scale variables. In the paper we propose to improve the estimation accuracy for large-dimensional factor model when a network structure between…

统计方法学 · 统计学 2020-01-30 Long Yu , Yong He , Xinsheng Zhang , Ji Zhu

We address the problem of inferring the topology of a wireless network using limited observational data. Specifically, we assume that we can detect when a node is transmitting, but no further information regarding the transmission is…

网络与互联网体系结构 · 计算机科学 2025-07-03 James Martin , Tristan Pryer , Luca Zanetti

Many collective systems exist in nature far from equilibrium, ranging from cellular sheets up to flocks of birds. These systems reflect a form of active matter, whereby individual material components have internal energy. Under specific…

软凝聚态物质 · 物理学 2023-04-17 Namid R. Stillman , Silke Henkes , Roberto Mayor , Gilles Louppe