相关论文: MAPK Cascades as Feedback Amplifiers

Collective cell migration is a hallmark of developmental and patho-physiological states, including wound healing and invasive cancer growth. The integrity of the expanding epithelial sheets can be influenced by extracellular cues, including…

Network cascade refers to diffusion processes in which outcome changes within part of an interconnected population trigger a sequence of changes across the entire network. These cascades are governed by underlying diffusion networks, which…

We present an information-theoretic formalism to study signal transduction in four architectural variants of a model two-step cascade with increasing input population. Our results categorize these four types into two classes depending upon…

Traditional percolation theory assumes static microscopic rules, limiting its ability to describe real-world complex systems where macroscopic order actively regulates local interactions. Here, we introduce feedback percolation, an unified…

The mechanisms underlying collective migration, or the coordinated movement of a population of cells, are not well understood despite its ubiquitous nature. As a means to investigate collective migration, we consider a wound healing…

A model for autonomous feedback control of particle transport through a large number of channels is introduced. Interactions among the particles can lead to a strong suppression of fluctuations in the particle number statistics. Within a…

A multiplicative cascade can be thought of as a randomization of a measure on the boundary of a tree, constructed from an iid collection of random variables attached to the tree vertices. Given an initial measure with certain regularity…

Multienzyme cascaded reactions are widely utilized because they can generate value-added biomaterials and biodevices from simple raw materials. However, how to promote the catalytic efficiency and synergistic effect of the multienzyme…

In real world social networks, there are multiple cascades which are rarely independent. They usually compete or cooperate with each other. Motivated by the reinforcement theory in sociology we leverage the fact that adoption of a user to…

Amplification underlies the operation of many biological and engineering systems. Simple electrical, optical, and mechanical amplifiers are reciprocal: the backward coupling of the output to the input equals the forward coupling of the…

Using computational modelling, we investigate mechanisms of signal transduction focusing on the spindle assembly checkpoint where a single unattached kinetochore is able to signal to prevent cell cycle progression. This inhibitory signal…

We investigate how to exploit intermittent feedback for interference management by studying the two-user Gaussian interference channel (IC). We approximately characterize (within a universal constant) the capacity region for the Gaussian IC…

The dynamics of cascading failures in spatial interdependent networks significantly depend on the interaction range of dependency couplings between layers. In particular, for increasing range of dependency couplings, different types of…

Several different enzymes display an apparent diffusion coefficient that increases with the concentration of their substrate. Moreover, their motion becomes directed in substrate gradients. Currently, there are several competing models for…

We discuss ``cascade mixing", where one particle mixture, say a B0, leads to another, say a K0. A simple analysis is possible in the amplitude approach, which avoids ``collapses of the wavefunction" and is explicitly covariant. Some novel…

We study cascades on a two-layer multiplex network, with asymmetric feedback that depends on the coupling strength between the layers. Based on an analytical branching process approximation, we calculate the systemic risk measured by the…

We report the first study of a network of connected enzyme-catalyzed reactions, with added chemical and enzymatic processes that incorporate the recently developed biochemical filtering steps into the functioning of this biocatalytic…

Intracellular biochemical networks fluctuate dynamically due to various internal and external sources of fluctuation. Dissecting the fluctuation into biologically relevant components is important for understanding how a cell controls and…

This paper investigates the uplink cascaded channel estimation for intelligent-reflecting-surface (IRS)-assisted multi-user multiple-input-single-output systems. We focus on a sub-6 GHz scenario where the channel propagation is not sparse…

We numerically study the multi-scale properties of a 2d active gel to address the energy transfer mechanism. We find that activity is able to excite long-ranged distortions of the nematic pattern giving rise to spontaneous laminar flows and…