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Mathematical models of stem cell differentiation are commonly based upon the concept of subsequent cell fate decisions, each controlled by a gene regulatory network. These networks exhibit a multistable behavior and cause the system to…

定量方法 · 定量生物学 2011-07-06 Christian Breindl , Daniella Schittler , Steffen Waldherr , Frank Allgöwer

The spontaneous generation of electrical activity underpins a number of essential physiological processes, and is observed even in tissues where specialized pacemaker cells have not been identified. The emergence of periodic oscillations in…

适应与自组织系统 · 物理学 2022-02-01 Ria Ghosh , Shakti N. Menon

Discrete dynamic models are a powerful tool for the understanding and modeling of large biological networks. Although a lot of progress has been made in developing analysis tools for these models, there is still a need to find approaches…

分子网络 · 定量生物学 2013-06-14 Jorge G. T. Zañudo , Réka Albert

Network science has experienced unprecedented rapid development in the past two decades. The network perspective has also been widely applied to explore various complex systems in great depth. In the first decade, fundamental…

物理与社会 · 物理学 2020-01-13 Aming Li , Yang-Yu Liu

This chapter discusses the interplay between structure and dynamics in complex networks. Given a particular network with an endowed dynamics, our goal is to find partitions aligned with the dynamical process acting on top of the network. We…

社会与信息网络 · 计算机科学 2020-05-08 Michael T. Schaub , Jean-Charles Delvenne , Renaud Lambiotte , Mauricio Barahona

Network theory has unveiled the underlying structure of complex systems such as the Internet or the biological networks in the cell. It has identified universal properties of complex networks, and the interplay between their structure and…

物理与社会 · 物理学 2015-09-21 Ginestra Bianconi

Individual nodes in evolving real-world networks typically experience growth and decay --- that is, the popularity and influence of individuals peaks and then fades. In this paper, we study this phenomenon via an intrinsic nodal fitness…

物理与社会 · 物理学 2015-05-20 Xin-Jian Xu , Xiao-Long Peng , Michael Small , Xin-Chu Fu

The topological structure of the power grid plays a key role in the reliable delivery of electricity and price settlement in the electricity market. Incorporation of new energy sources and loads into the grid over time has led to its…

社会与信息网络 · 计算机科学 2015-03-02 Deepjyoti Deka , Sriram Vishwanath

We develop the theory of linear evolution equations associated with the adjacency matrix of a graph, focusing in particular on infinite graphs of two kinds: uniformly locally finite graphs as well as locally finite line graphs. We discuss…

动力系统 · 数学 2018-07-26 Delio Mugnolo

We present a thorough inspection of the dynamical behavior of epidemic phenomena in populations with complex and heterogeneous connectivity patterns. We show that the growth of the epidemic prevalence is virtually instantaneous in all…

无序系统与神经网络 · 物理学 2007-05-23 Marc Barthelemy , Alain Barrat , Romualdo Pastor-Satorras , Alessandro Vespignani

In this paper we consider nodes in network are heterogeneous and the link between nodes is caused by the potential dynamical demand of the nodes. Such demand can be measured by gravitation which increases with the heterogeneous strength of…

物理与社会 · 物理学 2008-01-30 Jiang-Hai Qian , Ding-Ding Han

Ecology and evolution are inseparable. Motivated by some recent experiments, we have developed models of evolutionary ecology from the perspective of dynamic networks. In these models, in addition to the intra-node dynamics, which…

种群与进化 · 定量生物学 2009-11-10 Debashish Chowdhury , Dietrich Stauffer

We demonstrate how concepts of statistical mechanics of interacting particles can have important implications in the choice of interaction potentials to model qualitative properties of cell aggregates in theoretical biology. We illustrate…

细胞行为 · 定量生物学 2017-06-29 J. A. Carrillo , A. Colombi , M. Scianna

In the framework of coupled cell systems, a coupled cell network describes graphically the dynamical dependencies between individual dynamical systems, the cells. The fundamental network of a network reveals the hidden symmetries of that…

组合数学 · 数学 2017-12-06 Manuela A D Aguiar , Ana P S Dias , Pedro Soares

Demonstrations, protests, riots, and shifts in public opinion respond to the coordinating potential of communication networks. Digital technologies have turned interpersonal networks into massive, pervasive structures that constantly…

物理与社会 · 物理学 2017-03-14 Pablo Piedrahita , Javier Borge-Holthoefer , Yamir Moreno , Sandra González-Bailón

Competitive interactions represent one of the driving forces behind evolution and natural selection in biological and sociological systems. For example, animals in an ecosystem may vie for food or mates; in a market economy, firms may…

物理与社会 · 物理学 2013-07-03 Jacobo Aguirre , David Papo , Javier M. Buldú

Systems with the coexistence of different stable attractors are widely exploited in systems biology in order to suitably model the differentiating processes arising in living cells. In order to describe genetic regulatory networks several…

动力系统 · 数学 2010-07-16 V. Lanza , L. Ponta , M. Bonnin , F. Corinto

This work gives a mathematical study of tissue dynamics. We combine within-cell genome dynamics and diffusion between cells, where the synthesis of the two gives rise to the emergence of function. We introduce a concept of monotonicity and…

其他定量生物学 · 定量生物学 2016-10-17 Indika Rajapakse , Steve Smale

Virtually all real-world networks are dynamical entities. In social networks, the propensity of nodes to engage in social interactions (activity) and their chances to be selected by active nodes (attractiveness) are heterogeneously…

物理与社会 · 物理学 2017-06-13 Laura Alessandretti , Kaiyuan Sun , Andrea Baronchelli , Nicola Perra

We study the effect of learning dynamics on network topology. A network of discrete dynamical systems is considered for this purpose and the coupling strengths are made to evolve according to a temporal learning rule that is based on the…

混沌动力学 · 物理学 2009-11-13 Juergen Jost , Kiran M. Kolwankar